association of breast implant rupture and fibromyalgia.etc........

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1: Curr Rheumatol Rep. 2002 Aug;4(4):293-8.Links

An association of silicone-gel breast implant rupture and fibromyalgia.

Brown SL, Duggirala HJ, Pennello G.

US Food and Drug Administration, Epidemiology Branch, Center for Devices and Radiological Health, HFZ-541, 1350 Piccard Drive, Rockville, MD 20850, USA. syb@...

Silicone-gel breast implant rupture is common. Silicone-gel from ruptured implants may escape the scar capsule that forms around breast implants and become "extracapsular silicone." Our previously published study found that women with extracapsular silicone gel were at higher risk of reporting that they were diagnosed with fibromyalgia. There has been a limited number of studies addressing this association in the literature. Some studies addressing the issue of silicone breast implants and connective tissue disease specifically exclude patients with fibromyalgia from the sample or do not include the syndrome in the analysis. Case series describing fibromyalgia in patients with implants have been published, but many of these papers lack information on extracapsular silicone and are not representative because the patients are typically from referral populations. In addition, most studies do not have control groups of women without implants for comparison or do not distinguish between saline and silicone implants. Additional observational studies of women from nonreferral populations are necessary to validate an association. These studies should provide information on how the rupture is diagnosed, state whether the rupture extended beyond the capsule, and provide an appropriate control group for comparison. The findings from such studies may be important to physicians as they describe potential risks associated with implants to their patients. These findings should also be important for regulatory decision making on silicone-gel breast implants.

PMID: 12126580 [PubMed - indexed for MEDLINE]

An association of silicone-gel breast implant rupt...[Curr Rheumatol Rep. 2002] - PubMed Result

1: Diagn Cytopathol. 1993 Oct;9(5):498-502.Links

Fine-needle aspiration cytology of silicone granulomas in the augmented breast.

Dodd LG, Sneige N, Reece GP, Fornage B.

Department of Pathology, University of Texas M.D. Cancer Center, Houston.

We studied 12 aspirates from 10 patients who underwent diagnostic fine-needle aspiration cytology (FNAC) of an augmented or reconstructed breast. Six patients were augmented with silicone gel-filled implants and four patients had silicone liquid injections. FNAC indications included a painful or suspicious mass. Excisional biopsy was performed in six cases after FNAC. The findings of eight cases included modestly cellular smears composed of loosely cohesive histiocytes containing vacuoles of various sizes. Multinucleated foreign body giant cells, fragments of dense, amorphous fibrous tissue, and fibroblast nuclei stripped of cytoplasm were also present. Two patients showed a mixture of inflammatory cells characteristic of intramammary lymph nodes or lymphoid aggregates. We conclude that silicone granulomas of the breast show a characteristic set of findings on FNAC which enable a cytopathologist to render a specific diagnosis given an appropriate history of breast augmentation.

PMID: 8287755 [PubMed - indexed for MEDLINE]

Fine-needle aspiration cytology of silicone granul...[Diagn Cytopathol. 1993] - PubMed Result

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