Dispersion of silicone gel from breast implants SAD SAD SAD

[Guest guest]

This is the html version of the file http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/md-im/notes_32-eng.pdf.

Page 1

Dispersion of silicone gel from breast implants : Where does it go? What becomes of it?

Guidoin PhD

Departement of Surgery,

Faculty of Medecine, Universiyt of Laval

Quebec, Quebec G1K 7P4

Canada

All implants must meet the conditions of the 3B rule : biocompatibility, biofunctionnality and biodurability. In the framework of our retrieval program of analysis of breast implants after surgical explantation, we were in the position to identify different types of failure in breast

implants: o loss of silicone : presence of the material was frequently observed in the external capsule and in the lymph nodes regardless of the type of prosthesis and regardless of the duration of implantation;

o presence of cholesterol and various materials in the gel of silicone gel implants; o loss of volume in saline implants caused by a defect in the valve (in the short-term) or a defect in the shell (in the long-term);

o major damage to shell in prostheses covered with polyurethane foam; the fibrous proliferation in the polyurethane foam induces an uplift of the adhesive together with the silicone shell; o rupture in the shell by chemical degradation, accident and/or pressure of the external

capsulae, whether calcified or not. In this case, the prosthesis cannot withstand the pressure by the capsule and bursts.

Page 2

The question that is asked, then, is what becomes of the silicone dispersed in the human body.

Where does it appear? Is it evacuated through natural paths entirely or only in part?

Does silicone remain in the organs? Does it deteriorate or not?

An examination of tissues collected during the autopsy of a 70 year old patient who died of respiratory distress syndrome answers several of those questions.

Four years prior, the breast implants that she had worn for 16 years were removed.

1. Clinical Case

The 70 year old patient died of respiratory distress. At the age of 49, she underwent a sub-cutaneous mastectomy caused by cystic fibrosis. A bilateral augmentation with Cronin (200 ml) implants, made by Dow Corning Corporation, was carried out one year

later. Fourteen years after that, a rupture in the right implant was observed during a routine mammogram.

Sixteen years after their implantation, the prostheses were

explanted and the rupture in the right prosthesis was confirmed.

Ever since the rupture of the prosthesis, the patient showed numerous health problems including chronic fatigue syndrome, Sjorgen’s syndrome, Raynaud’s phenomenon and hypothyroidism. In addition, she developed a number of pulmonary problems during the

last five years of her life.

2. Autopsy Report

The areolar tissue of the lungs was severely damaged by chronic infection and emphysema. The lymph nodes appeared normal. The two heart ventricles were dilated

Page 3

while the coronary arteries were moderately atherosclerotic. Major arteries were atherosclerotic as well.

The tissue of the liver showed obvious necrosis. The thyroid gland appeared muldinodal with accumulation of gelatinous, yellowish materials in different locations; some calculus was equally observed.

The ogher organs did reveal any particularities visible to the naked eye.

3. Histological Exams

Pratically all of the tissues presented inflammatory reactions similar to those of foreign bodies, with polymorphonuclear cells, monoclear cells, macrophages and lymphocytes.

The macrophages comprised vacuoles containing what was a foreign substance, silicone, as confirmed by microanalysis. These observations were particularly abundant at the level of the lungs and the lymph nodes. The kidneys were damaged by nephrosclerosis. The liver and the pancreas were equally involved. Various lesions were also present in the brain.

4. Résonnance magnétique du solide

Solid state magnetic resonance of 29 Si with a Bruker MSL-400 machine at 9.4T has confirmed the degradation of silicone in the lung.

Page 4

In conclusion, we can confirm that :

1) silicone migrates into the body and reaches almost all of the organs;

2) regardless of the rate of natural elimination of silicone, part of it remains in the tissues;

3) silicone degrades in the lungs.

**************Looking for a car that's sporty, fun and fits in your budget? Read reviews on AOL Autos. (http://autos.aol.com/cars-BMW-128-2008/expert-review?ncid=aolaut00050000000017 )

[Guest guest]



Darling Dede:

Thank you for posting all of this great material. Dr. Guidoin is our friend, and he has spent time with us here in Edmonton. He is a gentle sweet man, and the powers that be made him take all of his articles regarding the dangers of breast implants off Tony Lambert's website. This made us all very sad and angry.

Honey, we both hope that you are feeling better....we love you...Lea and Superman

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~```

Dispersion of silicone gel from breast implants SAD SAD SAD

This is the html version of the file http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/md-im/notes_32-eng.pdf.Page 1Dispersion of silicone gel from breast implants : Where does it go? What becomes of it? Guidoin PhD Departement of Surgery, Faculty of Medecine, Universiyt of Laval Quebec, Quebec G1K 7P4 Canada All implants must meet the conditions of the 3B rule : biocompatibility, biofunctionnality and biodurability. In the framework of our retrieval program of analysis of breast implants after surgical explantation, we were in the position to identify different types of failure in breast implants: o loss of silicone : presence of the material was frequently observed in the external capsule and in the lymph nodes regardless of the type of prosthesis and regardless of the duration of implantation; o presence of cholesterol and various materials in the gel of silicone gel implants; o loss of volume in saline implants caused by a defect in the valve (in the short-term) or a defect in the shell (in the long-term); o major damage to shell in prostheses covered with polyurethane foam; the fibrous proliferation in the polyurethane foam induces an uplift of the adhesive together with the silicone shell; o rupture in the shell by chemical degradation, accident and/or pressure of the external capsulae, whether calcified or not. In this case, the prosthesis cannot withstand the pressure by the capsule and bursts. Page 2 The question that is asked, then, is what becomes of the silicone dispersed in the human body. Where does it appear? Is it evacuated through natural paths entirely or only in part? Does silicone remain in the organs? Does it deteriorate or not?An examination of tissues collected during the autopsy of a 70 year old patient who died of respiratory distress syndrome answers several of those questions. Four years prior, the breast implants that she had worn for 16 years were removed.1. Clinical CaseThe 70 year old patient died of respiratory distress. At the age of 49, she underwent a sub-cutaneous mastectomy caused by cystic fibrosis. A bilateral augmentation with Cronin (200 ml) implants, made by Dow Corning Corporation, was carried out one year later. Fourteen years after that, a rupture in the right implant was observed during a routine mammogram. Sixteen years after their implantation, the prostheses were explanted and the rupture in the right prosthesis was confirmed. Ever since the rupture of the prosthesis, the patient showed numerous health problems including chronic fatigue syndrome, Sjorgen’s syndrome, Raynaud’s phenomenon and hypothyroidism. In addition, she developed a number of pulmonary problems during the last five years of her life. 2. Autopsy ReportThe areolar tissue of the lungs was severely damaged by chronic infection and emphysema. The lymph nodes appeared normal. The two heart ventricles were dilated Page 3 while the coronary arteries were moderately atherosclerotic. Major arteries were atherosclerotic as well. The tissue of the liver showed obvious necrosis. The thyroid gland appeared muldinodal with accumulation of gelatinous, yellowish materials in different locations; some calculus was equally observed. The ogher organs did reveal any particularities visible to the naked eye.3. Histological ExamsPratically all of the tissues presented inflammatory reactions similar to those of foreign bodies, with polymorphonuclear cells, monoclear cells, macrophages and lymphocytes. The macrophages comprised vacuoles containing what was a foreign substance, silicone, as confirmed by microanalysis. These observations were particularly abundant at the level of the lungs and the lymph nodes. The kidneys were damaged by nephrosclerosis. The liver and the pancreas were equally involved. Various lesions were also present in the brain. 4. Résonnance magnétique du solideSolid state magnetic resonance of 29 Si with a Bruker MSL-400 machine at 9.4T has confirmed the degradation of silicone in the lung. Page 4 In conclusion, we can confirm that : 1) silicone migrates into the body and reaches almost all of the organs;2) regardless of the rate of natural elimination of silicone, part of it remains in the tissues; 3) silicone degrades in the lungs. **************Looking for a car that's sporty, fun and fits in your budget? Read reviews on AOL Autos.(http://autos.aol.com/cars-BMW-128-2008/expert-review?ncid=aolaut00050000000017 )