Autoantibodies in CHILDREN trans-mammary or trans-placental delivery

[Guest guest]

1: Int Arch Allergy Immunol. 1994;103(1):105-8.Links

Autoantibodies and clinical rheumatic complaints in two children of women with silicone gel breast implants.

Teuber SS, Gershwin ME.

Division of Rheumatology, Allergy, and Clinical Immunology, University of California, .

Considerable interest and efforts are directed at determining the extent to which silicone gel breast implants may contribute to the risk of developing autoimmune disease. There is also comparable interest in determining the extent to which silicone may alter the natural history of an established autoimmune disease. Recently, there has been concern over the possibility that children of women with silicone breast implants might somehow be adversely affected because of either trans-mammary or trans-placental delivery of silicone during either breast feeding or pregnancy. Herein, we describe two children of mothers with silicone breast implants, both female, aged approximately 3 and 9 years, both of whom had long-standing myalgias that were unexplained and did not fit current clinical criteria for juvenile arthritis. Both were found to have positive antinuclear antibodies. Additionally, the 9-year-old girl was found to have a significantly high titer of antibodies against denatured human type II collagen; indeed, her titer was six standard deviations above the mean for normal controls. There have been numerous previous studies which have documented an adverse impact of trace metals, chemicals and some medications on the morphologic and neurologic development of children exposed in utero. Much less information exists on potential toxicity experienced by a neonate through breast feeding, although examples of toxic transmission have been reported. In Western Europe, but not the United States, women with silicone breast implants are advised not to breast feed. Further research should address these concerns and, in particular, women with silicone breast implants, with evidence of leakage or rupture, should refrain from breast feeding until further data are obtained.

PMID: 8260844 [PubMed - indexed for MEDLINE]

Autoantibodies and clinical rheumatic complaints i...[int Arch Allergy Immunol. 1994] - PubMed Result **************Looking for a car that's sporty, fun and fits in your budget? Read reviews on AOL Autos. (http://autos.aol.com/cars-BMW-128-2008/expert-review?ncid=aolaut00050000000017 )

[Guest guest]

Wow, Dede, thanks for this one on the children....this is where I

think we need to focus our efforts on getting implants banned. The

kids should not have to suffer.

Patty

>

> 1: Int Arch Allergy Immunol. 1994;103(1):105-8.Links

>

> Autoantibodies and clinical rheumatic complaints in two children of

women

> with silicone gel breast implants.

> Teuber SS, Gershwin ME.

> Division of Rheumatology, Allergy, and Clinical Immunology,

University of

> California, .

>

> Considerable interest and efforts are directed at determining the

extent to

> which silicone gel breast implants may contribute to the risk of

developing

> autoimmune disease. There is also comparable interest in

determining the extent

> to which silicone may alter the natural history of an established

autoimmune

> disease. Recently, there has been concern over the possibility that

children of

> women with silicone breast implants might somehow be adversely

affected

> because of either trans-mammary or trans-placental delivery of

silicone during

> either breast feeding or pregnancy. Herein, we describe two

children of mothers

> with silicone breast implants, both female, aged approximately 3

and 9 years,

> both of whom had long-standing myalgias that were unexplained and

did not fit

> current clinical criteria for juvenile arthritis. Both were found

to have

> positive antinuclear antibodies. Additionally, the 9-year-old girl

was found to have

> a significantly high titer of antibodies against denatured human

type II

> collagen; indeed, her titer was six standard deviations above the

mean for normal

> controls. There have been numerous previous studies which have

documented an

> adverse impact of trace metals, chemicals and some medications on

the

> morphologic and neurologic development of children exposed in

utero. Much less

> information exists on potential toxicity experienced by a neonate

through breast

> feeding, although examples of toxic transmission have been

reported. In Western

> Europe, but not the United States, women with silicone breast

implants are advised

> not to breast feed. Further research should address these concerns

and, in

> particular, women with silicone breast implants, with evidence of

leakage or

> rupture, should refrain from breast feeding until further data are

obtained.

>

> PMID: 8260844 [PubMed - indexed for MEDLINE]

>

>

> Autoantibodies and clinical rheumatic complaints i...[int Arch

Allergy

> Immunol. 1994] - PubMed Result

>

>

> **************

> Looking for a car that's sporty, fun

> and fits in your budget? Read reviews on AOL Autos.

>

> (http://autos.aol.com/cars-BMW-128-2008/expert-review?

ncid=aolaut00050000000017 )

>