silicone injection leading to multi-system organ failure.

[Guest guest]

Wouldnt silicone injections be about the same as leaking silicone, or gel bleed ? ? ?

1: Clin Toxicol (Phila). 2008 Jun 14:1-4. [Epub ahead of print] Links

Subcutaneous silicone injection leading to multi-system organ failure.

RF, Cantrell FL, Pacal A, Chen W, Betten DP.

California Poison Control System- San Diego, and UCSD Division of Medical Toxicology, San Diego, California, USA.

Background. Silicone is an inert liquid polymer often chosen for cosmetic procedures due to its durability and thermal stability. Following silicone injection, end organ toxicity can occur. We report two cases of multiorgan dysfunction following silicone injection. Case report. Two transsexual males presented to the emergency department with altered consciousness after receiving subcutaneous injections of silicone into the hip and buttocks. Each patient had received injections totaling between one and two liters of silicone. Soon after the injections, each reported feeling nauseated and lethargic, and then lost consciousness. On arrival, each was somnolent, with tachycardia and hypotension. Lungs were clear and there were multiple injection sites of induration noted over the hips and gluteal regions. Laboratory screening showed leukocytosis and hemoconcentration in each, with no drugs found on urine toxicology screening. Chemistries were normal. Both became hypoxic on arterial blood gas analysis. Oxygenation worsened in each despite intubation and ventilator manipulation. Chest radiographs were initially clear but progressively showed adult respiratory distress syndrome. One patient gradually improved over several days, was extubated, and recovered neurologically. The second patient continued to be hypoxic, never regained neurologic function, and expired three weeks after presentation. Post-mortem examination revealed clinical respiratory failure with organizing pneumonia, adult respiratory distress syndrome, and foreign body giant cell reactions to silicone. Additionally, multiple small subacute brain white matter infarcts consistent with silicone embolization were found. Conclusion. Clandestine application of silicone for body enhancement is common and clinicians should be aware of the potential complications.

PMID: 18608261 [PubMed - as supplied by publisher]

Subcutaneous silicone injection leading to multi-s...[Clin Toxicol (Phila). 2008] - PubMed Result

1 **************Looking for a car that's sporty, fun and fits in your budget? Read reviews on AOL Autos. (http://autos.aol.com/cars-BMW-128-2008/expert-review?ncid=aolaut00050000000017 )

[Guest guest]

Absolutely Dede

>

> Wouldnt silicone injections be about the same as leaking silicone,

or gel

> bleed ? ? ?

>

> 1: Clin Toxicol (Phila). 2008 Jun 14:1-4. [Epub ahead of print]

Links

>

> Subcutaneous silicone injection leading to multi-system organ

failure.

> RF, Cantrell FL, Pacal A, Chen W, Betten DP.

> California Poison Control System- San Diego, and UCSD Division of

Medical

> Toxicology, San Diego, California, USA.

>

> Background. Silicone is an inert liquid polymer often chosen for

cosmetic

> procedures due to its durability and thermal stability. Following

silicone

> injection, end organ toxicity can occur. We report two cases of

multiorgan

> dysfunction following silicone injection. Case report. Two

transsexual males presented

> to the emergency department with altered consciousness after

receiving

> subcutaneous injections of silicone into the hip and buttocks. Each

patient had

> received injections totaling between one and two liters of

silicone. Soon after the

> injections, each reported feeling nauseated and lethargic, and then

lost

> consciousness. On arrival, each was somnolent, with tachycardia and

hypotension.

> Lungs were clear and there were multiple injection sites of

induration noted

> over the hips and gluteal regions. Laboratory screening showed

leukocytosis and

> hemoconcentration in each, with no drugs found on urine toxicology

screening.

> Chemistries were normal. Both became hypoxic on arterial blood gas

analysis.

> Oxygenation worsened in each despite intubation and ventilator

manipulation.

> Chest radiographs were initially clear but progressively showed

adult

> respiratory distress syndrome. One patient gradually improved over

several days, was

> extubated, and recovered neurologically. The second patient

continued to be

> hypoxic, never regained neurologic function, and expired three

weeks after

> presentation. Post-mortem examination revealed clinical respiratory

failure with

> organizing pneumonia, adult respiratory distress syndrome, and

foreign body giant

> cell reactions to silicone. Additionally, multiple small subacute

brain white

> matter infarcts consistent with silicone embolization were found.

Conclusion.

> Clandestine application of silicone for body enhancement is common

and

> clinicians should be aware of the potential complications.

> PMID: 18608261 [PubMed - as supplied by publisher]

>

> Subcutaneous silicone injection leading to multi-s...[Clin Toxicol

(Phila).

> 2008] - PubMed Result

>

> 1

>

>

> **************

> Looking for a car that's sporty, fun and fits in your

> budget? Read reviews on AOL Autos.

>

> (http://autos.aol.com/cars-BMW-128-2008/expert-review?

ncid=aolaut00050000000017 )

>