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Use of Di(2-ethylhexyl) Phthalate–Containing Medical Products and ...

Medical devices containing DEHP are used extensively in neonatal ..... Toxic potential of the plasticizer di(2-ethylhexyl) phthalate in the context of its ...http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1280405 - similar pages

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Environ Health Perspect. 2005 September; 113(9): 1222–1225.

Published online 2005 June 8. doi: 10.1289/ehp.7932.

Research

Children's Health

Use of Di(2-ethylhexyl) Phthalate–Containing Medical Products and Urinary Levels of Mono(2-ethylhexyl) Phthalate in Neonatal Intensive Care Unit Infants

Green,1 Russ Hauser,1 Antonia M. Calafat,2 Weuve,1 Ted Schettler,3 Ringer,4 Huttner,5 and Hu1,6

1Department of Environmental Health, Harvard School of Public Health , Boston , Massachusetts , USA

2Centers for Disease Control and Prevention, Atlanta , Georgia , USA

3Science and Environmental Health Network, Boston , Massachusetts , USA

4Neonatology Unit, Brigham and Women’s Hospital, Harvard Medical School , Boston , Massachusetts , USA

5Neonatology Unit, Massachusetts General Hospital , Harvard Medical School , Boston , Massachusetts , USA

6Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School , Boston , Massachusetts , USA

Address correspondence to H. Hu, Harvard School of Public Health, Department of Environmental Health, Landmark Center East 3-110A, 401 Park Dr. , Boston , MA 02215 USA . Telephone: (617) 384-8968. Fax: (617) 384-8994. E-mail: hhu@...

The authors declare they have no competing financial interests.

Received January 17, 2005; Accepted May 26, 2005.

Abstract

Objective: Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in medical products made with polyvinyl chloride (PVC) plastic and may be toxic to humans. DEHP is lipophilic and binds non-covalently to PVC, allowing it to leach from these products. Medical devices containing DEHP are used extensively in neonatal intensive care units (NICUs). Among neonates in NICUs, we studied exposure to DEHP-containing medical devices in relation to urinary levels of mono(2-ethylhexyl) phthalate (MEHP), a metabolite of DEHP.

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