patent for silicone in implants.....ingredients part 3

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TABLE 5

______________________________________

SILOXANE COMPOSITION OF EXPERIMENTAL

COATINGS FORMULATION

INGREDIENT CONTENT, wt %

______________________________________

Vinyl Fluid (2000 cstk)

92.82

Crosslinker, MD43.2 D'6.8 M

7.18

______________________________________

TABLE 6

______________________________________

COMPARISON OF TEMPORARY CATALYST

INHIBITIORS

INHIBITOR AND CONCN., GEL TIME,

104 mole Pt, 106 mole

sec

______________________________________

COMPARATIVE 1.71 97

EXAMPLES

NO INHIBITOR

DIETHYL MALEATE

0.232 3.90 174

1.626 5.75 245

3.543 2.63 320

METHVINYLCYCS*,

0.145 3.41 162

0.261 2.92 222

ILLUSTRATIVE

EXAMPLES

n-C8 H17 SiH3

2.217 2.63 121

4.365 2.63 151

6.721 2.63 211

2.217 1.85 118

4.43 1.75 200

______________________________________

*Tetramethyltetravinylcyclotetrasiloxane

It is clear from Table 6 that all three temporary catalyst inhibitors

lengthen the gel times. The extent of the inhibition depends both on the

inhibitor and platinum concentrations. Although n-octylsilane is less

potent than the other two inhibitors shown, it offers good processing

latitude and the additional advantage of excellent adhesion of the coating

to the thermoplastic substrate.

Example 8

This example illustrates the use of SiH3 -containing additives as

primers for polyurethane-polyester films.

The two-part formulation described in Example 3 was used without

n-octylsilane in PART A. Equal weights of Parts A and B were combined,

stirred mechanically and then deaerated in vacuo for 10 minutes. The films

were U01 from Atochem and a sample from & Nephew (S & N). Gel

sandwiches were prepared with primed and unprimed control films and cured

at 125° C. for 45 minutes as described above (vide supra Gel

Testing). The primers were applied as neat liquids by brushing or

spraying. Primed films were left undisturbed at ambient temperature for

15-60 min (drying time) before the gel sandwiches were made. The results

of qualitative manual pull tests are summarized in Table 7.

The results show that good bonding occurred at the gel-film interface

whenever n-octylsilane or phenylsilane was used as a primer. The locus of

failure during the manual pull tests was within the gel (cohesive failure)

and not at the gel-film interface. Unprimed films showed unacceptable

gel-film bonding and failed adhesively.

TABLE 7

______________________________________

USE OF SiH3 -CONTAINING ADDITIVES AS SURFACE

PRIMERS

FILM DRYING ADHESION

PRIMER SAMPLE TIME min RESULTS

______________________________________

n-C8 H17 SiH3

U01 both 60 cohesive failure

surfaces 30 cohesive failure

15 cohesive failure

NONE U01 both adhesive failure

surfaces

n-C8 H17 SiH3

U01 Top 30 cohesive failure

Surface on top adhesive

only failure on lower

primed. surface.

n-C8 H17 SiH3

S & N both 15 cohesive failure

surfaces

C6 H5 SiH3

U01 both 60 cohesive failure

surfaces

______________________________________

While the invention has been described in detail and with reference to

specific embodiments thereof, it will be apparent to those of ordinary

skill in the art that various changes and modifications can be made

therein without departing from the spirit and scope thereof.

The entire contents of all references mentioned above are incorporated

herein by reference.

* * * * *

Other References

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Leeper, et al., "Elastomers in Medicine", Rubber Chemistry And Technology, vol. 56, (1983) pp. 523-556

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Designation: D 1403-86, number of pages 8, "Standard Test Method for Cone Penetration of Lubricating Grease Using One-Quarter and One-Half Scale Cone Equipment"

Osada et al., "Intelligent Gels", 82 Scientific American May 1993, pp. 82-87

Almdal, et al., "Towards a Phenomenological Definition of the Term`Gel`", Polymer Gels and Networks 1 (1993), pp. 5-1

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