Guest guest Posted August 8, 2008 Report Share Posted August 8, 2008 Ilena, I, like you, am so glad to see these articles reposted and the truth being told as often as we need to! It's always a joy to see you posting on our group. We've got a file on the website with studies recorded...Dede, if any of these are not listed, please let me know so we can get them in the files for ease in finding them in the future. You are a blessing, dear women! Patty > > > > > > > > Begin forwarded message: > > > > *From: *DGrahamA@... > > *Date: *August 6, 2008 4:08:40 PM MDT > > **DGrahamA@... > > *Subject: **Large Cell Lymphoma Arising in a Silicone Breast Implant > > Capsule* > > > > > > http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985 (2003)127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document > > > > > > *Archives of Pathology and Laboratory Medicine: Vol. 127, No. 3, pp. > > e115–e118.* > > > > > > *Anaplastic Large Cell Lymphoma Arising in a Silicone Breast Implant > > Capsule: A Case Report and Review of the Literature > > * > > > > * Sunati Sahoo, MD; P. Rosen, MD; M. Feddersen,MD; S. > > Viswanatha, MD; A. , MD; Amy Chadburn, MD* > > > > > > > > *from the Department ofPathology, New York Presbyterian Hospital- Weill > > Cornell Center, NewYork, NY (Drs Sahoo, Rosen, and Chadburn); the Department > > of Pathology,University of New Mexico School of Medicine, Albuquerque (Drs > > Feddersenand Viswanatha); and New Mexico Oncology Hematology > > Consultants,Albuquerque (Dr )* > > > > Accepted June 14, 2002 > > *Anaplastic large cell lymphoma is a rare type of primary breastlymphoma. > > We report a case of anaplastic large cell lymphoma, T- cellphenotype, > > occurring in the periprosthetic capsule of a silicone breastprosthesis 9 > > years after implantation for augmentation mammoplasty.This case is unique > > for its unusual presentation. > > > > *Since 1962, an estimated 1 to 2 million women have acquired breast > > implants in the United States.1<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b1>Approximately > > 80% of these implants have been placed for breastaugmentation, and almost > > all of the others have been used forreconstruction after mastectomy due to > > cancer.1<http://arpa.allenpress.com/arpaonline/?doi=10.1043% 2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b1>The > > physical and psychological benefits of breast implants formastectomy > > patients have been well documented. Despite early reportsthat silicone was > > biologically inert in human tissue, the safety ofbreast implants for > > augmentation mammoplasty has been a subject of muchdiscussion with respect > > to local and potential systemic complications,including carcinogenic > > effects. An independent panel of US scientistsconvened at the request of > > Congress concluded that silicone breastimplants do not cause any systemic > > disease, but these implants can leakand rupture, causing local problems such > > as scarring, infection, anddisfigurement. There is no convincing evidence > > that these local effectspredispose women to the development of lymphoma in > > the breast, althoughthere have been rare reports of lymphoma in the vicinity > > of breastimplants.2–4<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#i1543-2165-127-3-e115-b2>This > > report documents a case of primary anaplastic large cell lymphoma (ALCL) of > > the breast that arose in the periprosthetic tissue of asilicone implant. > > > > > > *REPORT OF A CASE* Return to TOC<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#TOC> > > > > > > A33-year-old woman underwent bilateral cosmetic breast > > augmentationmammoplasty with double-lumen silicone prostheses in 1986. In > > August1990, she developed tenderness at the left breast implant site, > > whichled to the removal of the capsule. Histopathologic examination of > > thecapsule revealed chronic inflammation, fibrosis, and foreign body > > giantcell reaction. Two months later, the left breast prosthesis was > > removedbecause of secondary infection. In February 1991, following > > antibiotictherapy and surgical debridement, a new silicone gel– filled > > prosthesiswas placed. The patient was asymptomatic until March 2000, when > > shepresented with swelling and tenderness at the left breast implant site.At > > surgery, a substantial amount of straw-colored fluid was drainedfrom the > > periprosthetic capsular space. The prosthesis was removedfollowed by > > capsulectomy. Morphologic examination of the capuslectomyspecimen revealed > > an atypical mononuclear cell infiltrate that,following immunophenotypic and > > genotypic studies, was diagnosed aslymphoma. Further evaluation of the > > patient revealed no systemicdisease. She was treated with radiotherapy and 3 > > cycles ofcyclophosphamide, doxorubicin, vincristine, and prednisone. > > Twelvemonths after diagnosis, she is alive with no evidence of disease. Her > > right breast implant was intact. > > > > > > *MATERIALS AND METHODS* Return to TOC<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#TOC> > > > > > > *Immunohistochemistry* > > > > > > Immunophenotypicanalysis was performed on paraffin-embedded tissue sections > > using aTechMate 500 automated immunostainer (Ventana Medical Systems, > > Inc,Tucson, Ariz) according to a modified MIP protocol (Ventana Medical).The > > monoclonal and polyclonal antibodies to the various antigens andthe > > corresponding antigen retrieval methods are listed in Table 1<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-t01>.The ChemMate avidin-biotin complex peroxidase secondary detectionsystem, > > employing diaminobenzidine as the chromogen (Ventana Medical),was used to > > detect antigen expression. > > > > *Molecular Genetic Studies* > > > > > > Tomaximize the isolation of DNA from tumor cells, microdissection > > wasperformed from tissue sections. DNA was extracted using the QIAampTissue > > Kit (Qiagen Inc, Santa Clarita, Calif) according to themanufacturer's > > instructions. Polymerase chain reaction analysis wasperformed along with > > appropriate positive and negative controls toexamine immunoglobulin heavy > > chain (IgH), T-cell receptor ß chain, andT-cell receptor ? chain gene > > rearrangements. > > > > > > *In Situ Hybridization Studies* > > > > > > Insitu hybridization for the Epstein-Barr virus was performed > > onparaffin-embedded tissue sections using an EBER probe ISH kit (Novocastra, > > Newcastle upon Tyne, United Kingdom), according to themanufacturer's > > protocol. > > > > > > *PATHOLOGIC FINDINGS* Return to TOC<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#TOC> > > > > > > Ongross examination, the capsulectomy specimen consisted of a 10.0 ×8.0-cm > > fibromembranous sac up to 3.0 cm in thickness. The inner surfaceof the > > capsule was focally lobulated and covered by necrotic material.The specimen > > was fixed in 10% buffered formalin and extensively sampledfor > > histopathologic examination and ancillary studies. Microscopically,a layer > > of necrotic debris associated with scattered sclerotic nodulescovered the > > inner surface of the capsule. Immediately beneath thenecrotic layer, an > > approximately 1-mm-thick infiltrate of largeatypical mono- and > > multinucleated cells with frequent mitoses waspresent. The neoplastic cells > > were large and had clear cytoplasm, largenuclei, and prominent nucleoli (Figure, > > a<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-f01>).Unstained refractile material consistent with silicone particles wasseen > > in empty spaces in the sclerotic nodules and the cellularinfiltrate (Figure, > > b<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-f01>).Fibrosis and aggregates of chronic inflammatory cells, including > > smalllymphocytes, plasma cells, and histiocytes, were present outside > > theneoplastic infiltrate. > > > > > > *RESULTS* Return to TOC<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#TOC> > > > > > > The neoplastic cells were positive for the T-cell–associated antigens CD2 > > and CD43 (Figure, c<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#i1543-2165-127-3-e115-f01>) but lacked expression of CD3, consistent with a T-cell neoplasm. The cells > > were CD30 positive (Figure, d<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-f01>)and focally positive for epithelial membrane antigen. Immunostainingfor > > ALCL kinase protein (ALK-1), T-cell intracellular antigen, andlatent nuclear > > antigen of human herpesvirus 8 was negative (Table 1<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-t01>).In situ hybridization for the Epstein-Barr virus was also negative. > > PCRanalysis showed a monoclonal band for T-cell receptor ? and apolyclonal > > pattern for IgH and T-cell receptor ß. Based on thesestudies, the diagnosis > > of CD30-positive ALCL was reached. > > > > > > > > > > > > *COMMENT* Return to TOC<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#TOC> > > > > > > > > Primary non-Hodgkin lymphoma of the breast is rare and represents 0.04% to > > 0.5% of all malignant breast tumors.5<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b5>The > > vast majority of breast lymphomas are of B-cell origin. Only rarecases of > > T-cell breast lymphoma have been reported either as singlecase reports and > > as part of a series, including one series of 4patients with T- cell neoplasms > > in the breast.5<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#i1543-2165-127-3-e115-b5>Included > > in these reports are lymphoblastic lymphoma, peripheral T- celllymphoma, > > multilobated T-cell lymphoma, mycosis fungoides, naturalkiller cell > > lymphoma, and ALCL. > > > > Anaplasticlarge cell lymphoma accounts for approximately 3% of adult > > non-Hodgkinlymphomas and involves both lymph nodes and extranodal sites.6<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b6>Extranodal ALCL has been found in the skin (21%), soft tissues (17%), bone > > (17%), lung (11%), and liver (8%).6<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-b6>Involvement > > of the breast is rare in ALCL. There have been only 3reports of primary > > breast ALCL, including one case in proximity to asaline-filled implant.2,<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b2> > > 5,<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-b5> > > 7<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-b7>Furthermore, 3 additional cases of secondary ALCL of the breast have been > > reported.8,<http://arpa.allenpress.com/arpaonline/?doi=10.1043% 2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b8> > > 9<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-b9>The demographic and follow-up data on these previously reported ALCLs of the > > breast are summarized in Table 2<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-t02>.Preliminary data suggest that the most important prognostic indicatorof > > ALCL is ALK-1 positivity, which has been associated with a > > favorableprognosis. The overall 5-year survival rate in ALK-1– positive ALCL > > isclose to 80%, in contrast to only 40% in ALK-1–negative cases.6<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b6>In only 1 of 6 previously reported cases was the ALK-1 stain reported to be > > positive7<http://arpa.allenpress.com/arpaonline/?doi=10.1043% 2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b7>;in > > the remaining cases the ALK-1 status was unknown. The present caseof ALCL > > was ALK-1 negative and was limited to the breast, and thepatient showed > > resolution of her lymphoma after chemotherapy. Fromthese isolated cases, > > with the limited follow-up data and unknownstatus of ALK-1 expression, it is > > difficult to predict the clinicalcourse of primary CD30-positive ALCL of the > > breast. > > > > Thepresenting symptom in virtually all cases of primary breast lymphoma isa > > mass-type lesion, which is sometimes painful and is located mostoften in the > > upper outer quadrant.10<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#i1543-2165-127-3-e115-b10>In > > contrast, patients who developed breast lymphoma followingprosthesis > > implantation had implant-related symptoms with or without amass- type lesion. > > Table 3<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-t03>summarizes the clinical and pathologic features of lymphoma in thepatients > > with either primary or secondary ALCL of the breast associatedwith an > > implant, including the current case (case 1). In case 2, acomputed > > tomography scan of the chest demonstrated circumferentialencasement of the > > right breast implant with tumor.2<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b2>In > > case 3, a computed tomography scan of the chest revealed fluidaccumulation > > between the capsule and implant, but a magnetic resonanceimage of the breast > > was unremarkable. Aspiration of the effusion wasdiagnostic of a > > CD30-positive, CD43-positive B-cell lymphoma.3<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003- 9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get- document#i1543-2165-127-3-e115-b3>In > > case 4, the patient developed discomfort in the breast, and > > physicalexamination revealed a significant capsular contracture and a > > smallpalpable nodule.4<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#i1543-2165-127-3-e115-b4>In > > all 4 patients with primary CD30-positive lymphoma, the neoplasticprocess > > was detected during the workup of implant-relatedcomplications, and in 2 > > patients (including the woman of this report),the diagnosis of lymphoma was > > made only after pathologic examination.These cases emphasize the need for > > careful pathologic examination oftissue removed because of implant-related > > complications. > > > > Currently,there is no evidence available directly relating lymphoma to > > siliconebreast prostheses. The sporadic cases of lymphoma developing in > > breastswith implants and in lymph nodes with silicone granulomas have > > occurredin patients with draining prosthestic joint replacements for > > fingerjoint arthritis.11– 13<http://arpa.allenpress.com/arpaonline/?doi=10.1043%2F0003-9985% 282003%29127%3Ce115:ALCLAI%3E2.0.CO%3B2 & request=get-document#i1543- 2165-127-3-e115-b11>Because > > only 4 cases of implant-related lymphoma in the breast havebeen reported > > from among more than 1 million women with breastimplants, the occurrence of > > lymphoma in these women may be unrelated tothe implants. Nonetheless, the > > localization of lymphoma inperiprosthetic breast tissue is noteworthy. > > > > *References* Return to TOC<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#TOC> > > > > > > 1. Noone RB. A review of the possible health implications of silicone > > breast implants. *Cancer* 1997;79:1747–1756. > > 2. Keech JA, Creech BJ. Anaplastic T-cell lymphoma in proximity to a > > saline-filled breast implant. *Plast Reconstr Surg* 1997;100:554– 555. [PubMed > > Citation<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? db=PubMed & cmd=Retrieve & list_uids=9252643 & dopt=Citation> > > ] > > 3. Said JW, Tasaka T, TakeuchiS. et al. Primary effusion lymphoma in women: > > report of two cases ofKaposi's sarcoma herpes virus-associated > > effusion-based lymphoma inhuman immunodeficiency virus-negative women. * > > Blood* 1996;88:3124–3148. [PubMed Citation<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? db=PubMed & cmd=Retrieve & list_uids=8874212 & dopt=Citation> > > ] > > 4. Cook PD, Osborne BM, ConnorRL, Strauss JF. Follicular lymphoma adjacent > > to foreign bodygranulomatous inflammation and fibrosis surrounding silicone > > breastprosthesis. *Am J Surg Pathol* 1995;19:712–717. [PubMed Citation<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? db=PubMed & cmd=Retrieve & list_uids=7755157 & dopt=Citation> > > ] > > 5. Aguilera NS, Tavassoli FA,Chu WS, Abbondanzo SL. T-cell lymphoma > > presenting in the breast: ahistologic, immunophenotypic and molecular > > genetic study of four cases.*Mod Pathol* 2000;13:599–605. [PubMed > > Citation<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? db=PubMed & cmd=Retrieve & list_uids=10874662 & dopt=Citation> > > ] > > 6. Delsol G, Ralfkiaer E, SteinH, D, Jaffe ES. Anaplastic large cell > > lymphoma. In: Jaffe ES, NL, Stein H, Vardiman JW, eds. *World Health > > Organization Clasification of Tumours. Pathology & Genetics of Tumours of > > Haematopoietic and Lymphoid Tissues.* Lyon, France: IRAC Press; > > 2001:230–235. > > 7. Pillay P, Chetty R. Anaplastic large cell lymphoma of the breast. *Int > > J Surg Pathol* 1999;7:171–174. > > 8. Lin Y, Govindan R, Hess JL. Malignant hematopoietic breast tumors. *Am > > J Clin Pathol* 1997;107:177–186. [PubMed Citation<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? db=PubMed & cmd=Retrieve & list_uids=9024066 & dopt=Citation> > > ] > > 9. Tan PH, Sng ITY. Breast lymphoma—a pathologic study of 14 cases. *Ann > > Acad Med Singapore* 1996;25:783–790. [PubMed Citation<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? db=PubMed & cmd=Retrieve & list_uids=9055003 & dopt=Citation> > > ] > > 10. Rosen PP. Lymphoid and hematopoietic tumors. In: *Rosen's Breast > > Pathology.* New York, NY: Lippincott-Raven; 1997:757–778. > > 11. E, Ahmed A, RashioATMF, DH. Silicone lymphadenopathy: a > > report of two cases, onewith concomitant malignant lymphoma. *Diagn > > Histopathol* 1982;5:133–141. [PubMed Citation<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? db=PubMed & cmd=Retrieve & list_uids=7047120 & dopt=Citation> > > ] > > 12. Digby JM. Malignant lymphoma with intranodal silicone rubber particles > > following metacarpophalangeal joint replacements. *Hand* 1982;14:326–328. > > 13. Murakata LA, Ruagwala AF. Silicone lymphadenopathy with concomitant > > malignant lymphoma. *J Rheumatol* 1989;16:1481–1483. > > > > *Tables* Return to TOC<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#TOC> > > > > Table 1.Immunophenotypic Analysis: Methods and Results > > > > Table 2.Summary of Previous Reports of CD30-Positive Anaplastic Large Cell > > Lymphoma of the Breast > > > > Table 3.Summary of Previously Reported Breast Lymphomas Associated With > > Implants > > > > *Figures* Return to TOC<http://arpa.allenpress.com/arpaonline/? doi=10.1043%2F0003-9985%282003%29127%3Ce115:ALCLAI%3E2.0.CO% 3B2 & request=get-document#TOC> > > > > > > Click on thumbnail for full-sized image. > > > > a,Neoplastic breast cells are large and have clear cytoplasm, largenuclei, > > and prominent nucleoli. An overlying layer of fibrinousmaterial is also > > present (hematoxylin-eosin, original magnification×20). b, Empty spaces > > containing unstained refractile materialconsistent with silicone particles > > (black arrows) are often in closeproximity to the tumor cells (white arrow) > > (hematoxylin-eosin, originalmagnification ×40). c, Neoplastic cells express > > the T-cell–associatedantigen CD43 (immunoperoxidase, original magnification > > ×20). d, Tumorcells are strongly positive for CD30 (BerH2, immunoperoxidase, > > originalmagnification ×20) > > > > Corresponding author: Amy Chadburn, MD, Department of Pathology, New > > YorkPresbyterian Hospital-Weill Cornell Center, 1300 York Ave, Room C > > 302,New York, NY 10021 (E-mail: achadbur@...) > > > > > > > > > > * > > > > * > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > ************** > > Looking for a car that's sporty, fun and fits in your budget? Read reviews > > on AOL Autos. > > ( > > http://autos.aol.com/cars-BMW-128-2008/expert-review? ncid=aolaut00050000000017) > > > > > > > > > -- > Ilena's Health Lover Blog > <http://ilenarose.blogspot.com> > > Breast Implant Awareness Blog > <http://breastimplantawareness.blogspot.com> > Quote Link to comment Share on other sites More sharing options...
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