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Re: * * * Siliconosis ( from breast implants ) * * * the best I have ever read ! !

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I hate that this stold my lifez focus 2 correct my statement of JUST LIFE as taking of the sickness overwelmbz U with not being able 2 type, speek think ,talk, alsoz I am filing 4 diability?! dont let boobeyz run your life (not take it) I have 2 go lie dowt all this siiting up hs be exoesded thank u 4 the info i kno.......

From: "DGRAHAMA@..." <DGRAHAMA@...>DGrahamA@...Sent: Sunday, March 8, 2009 2:36:21 PMSubject: * * * Siliconosis ( from breast implants ) * * * the best I have ever read ! !

Siliconosis: A spectrum of illness

Borenstein MD, Professor of MedicineAvailable online 13 May 2004. AbstractThe information reported at this symposium presents initial data supporting the notion that patients with exposure to silicone gel are experiencing a new illness. Previously, this disorder was described variously as “human adjuvant disease†and chronic silicone arthropathy.During the symposium, the term siliconosis and silicone implant syndrome (SIMS) was used to describe the clinical syndrome associated with patients receiving

silicone gel in liquid or encapsulated form. I prefer the term siliconosis because it is inclusive of symptomatic women who were exposed to silicone gel by injection or implant placement.Siliconosis is characterized by a spectrum of illness that may affect a number of organs. In its most common form, siliconosis is a musculoskeletal pain syndrome characterized by overwhelming fatigue, arthralgias, and myalgias. This form of the illness is reminiscent of a chronic flulike state.Influenza patients have overwhelming fatigue, fever, myalgias, and arthalgias. Common laboratory tests, such as complete blood count, erythrocyte sedimentation rate, and ANA are normal in individuals with influenza. It is difficult to document the presence of the virus, although the disease is diagnosed by physicians in the absence of positive viral cultures. Release of immune mediators (cytokines) by mononuclear cells is the most likely mechanism for the

presence of constitutional symptoms. A similar circumstance may occur with the release of cytokines by mononuclear cells ingesting silicone.The criteria for classification of fibromylagia include generalized pain in symmetrical areas of the body including those above and below the waist. Also included is pain with palpation in 11 of 18 tender point sites. Other factors associated with fibromylagia include nonrestorative sleep, daytime fatigue, chronic headache, and irritable bowel syndrome. Criteria for chronic fatigue syndrome include persistent fatigue sufficient to reduce daily activity by 50% or more for a period over 6 months, along with chills, cervical lymphadenopathy, headaches, myalgias, sleep disturbance, and fever.Patients with silicone breast implants have similar but not identical symptoms associated with these other disorders.The severity of fatigue and the presence of a limited number of tender points

differentiates this illness from fibromyalgia and chronic fatigue syndrome.. Patients with fibromyalgia associated with siliconosis do not have symmetrical tender points. Most tender points are located above the waist, and < 11 are identified in these patients. Siliconosis also differs from chronic fatigue syndrome. Patients with breast implants do not have fever, which is a frequent manifestation of chronic fatigue syndrome. Laboratory tests are normal in chronic fatigue syndrome, whereas a third of symptomatic patients with silicone breast implants have abnormal laboratory tests including ANAs.In addition to the musculoskeletal symptoms associated with siliconosis, a minority of patients also experience skin rash, alopecia, fever, lymphadenopathy, and arthritis.A significant number of patients develop a Sjögren's-like disorder characterized by xerophthalmia and xerostomia. However, there is an absence of autoantibodies and

cellular infiltrates associated with classic Sjögren's syndrome.Systemic lupuslike syndrome may appear with arthralgias, skin rash, and fever in the absence of detectable ANA. Rheumatoid arthritis-like disease may be characterized by years of polyarthritis without significant erosions or periarticular osteopenia. Neurological symptoms in the form of shortterm memory loss, paresthesias, and neuropathy have been reported.The pathogenesis of this disorder remains to be determined. The report of Kossovsky suggests that the alterations in plasma proteins facilitate the ingestion of silicone by macrophages that initiate an immunological response characterized by a chronic inflammatory state that is associated with the production of autoantibody and cytokines. The capsule surrounding implants is a potential site for production of a number of immunologically active factors that could result in patient symptoms.

Inflammatory reaction, including lymphocytes, monocytes, and plasma cells, has been identified in implant patients, with or without overt leakage.Increased amounts of interleukin 2 have been detected in capsules surrounding breast implants. The presence of these factors may explain the reason for the presence of the syndrome in patients with intact implants. Clinical symptoms associated with this pathological immunological state may occur in genetically predisposed patients. Preliminary studies suggest that genetically predisposed patients may have the DR53 haplotype.Patients whose implants were removed have reported improvement in symptoms.The improvement is not immediate in most patients. Some patients report improvement that has its onset 12 months or more after explantation.. This time course of improvement does not follow a course expected with placebo effect. One would predict that improvement with

explantation would be immediate with placebo effect. Explantation of the implants, along with the surrounding capsule, removes a large amount of silicone from the patient. Improvement over 12 months or longer suggests that an abnormal immune response is decreasing with removal of the silicone. The amount of silicone that remains in patients with enlarged axillary lymph nodes may not be adequate, over time, to sustain the abnormal immune response. In some patients, the residual amounts of silicone may be adequate to sustain the pathological process. This group may contain the third of patients who do not improve with explantation.Finally, the current controversy involving silicone breast implants seems reminiscent of the debate surrounding the original patients with Lyme disease. The physicians who saw these first patients preferred to diagnose juvenile rheumatoid arthritis, a disease that they knew. Superficially, the illness

seemed to be juvenile rheumatoid arthritis because it occurred in children and caused arthritis. However, closer scrutiny revealed that the illness occurred in clusters and affected adults as well as children. The illness was not juvenile rheumatoid arthritis, but a new illness caused by Borrelia burgdorferi and transmitted by a tick (Ixodes dammini).Our current understanding of silicone breast implants is that silicone is not inert and has the capability of causing systemic tissue damage. The mechanism by which this agent results in a clinical disease that differs from other rheumatic disorders remains to be determined. The participants of this symposium hope that the data presented will heighten interest in this condition and result in additional studies to further define the disease and improve therapies for women who are symptomatic from silicone breast implants.Article Outline• ReferencesCorresponding author. Address reprint requests to Borenstein, MD, 2150 Pennsylvania Avenue, NW, Washington DC 20037.From the Division of Rheumatology, Department of Medicine, The Washington University Medical Center, Washington ScienceDirect - Seminars in Arthritis and Rheumatism : Siliconosis: A spectrum of illness http://www.scienced irect.com/ scienceReferences and further reading may be available for this article. To view references and further reading you must purchase this article. ScienceDirect - Seminars in Arthritis and Rheumatism : Siliconosis: A spectrum of illness ************ **Check all of your email inboxes from anywhere on the web. Try the new Email Toolbar now! (http://toolbar. aol.com/mail/ download. html?ncid= txtlnkusdown0000 0027)

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Praying for you Yavon....

>

> I hate that this  stold my lifez focus  2 correct my statement of JUST LIFE  

as taking of  the sickness overwelmbz U with not being able 2 type,  speek 

 think  ,talk,  alsoz  I am filing 4 diability?!  dont let boobeyz run your

life  (not take it)  I have 2 go lie dowt all this siiting up hs be exoesded 

thank u 4 the info  i kno.......

>

>

>

>

> ________________________________

> From: " DGRAHAMA@... " <DGRAHAMA@...>

> DGrahamA@...

> Sent: Sunday, March 8, 2009 2:36:21 PM

> Subject: * * * Siliconosis ( from breast implants ) * * * the

best I have ever read ! !

>

>

>

> Siliconosis: A spectrum of illness

>

> Abstract

>

> The information reported at this symposium presents initial data supporting

the notion that patients with exposure to silicone gel are experiencing a new

illness.. Previously, this disorder was described variously as “human adjuvant

disease†and chronic silicone arthropathy.

>

> During the symposium, the term siliconosis and silicone implant syndrome

(SIMS) was used to describe the clinical syndrome associated with patients

receiving silicone gel in liquid or encapsulated form. I prefer the term

siliconosis because it is inclusive of symptomatic women who were exposed to

silicone gel by injection or implant placement.

>

> Siliconosis is characterized by a spectrum of illness that may affect a number

of organs. In its most common form, siliconosis is a musculoskeletal pain

syndrome characterized by overwhelming fatigue, arthralgias, and myalgias. This

form of the illness is reminiscent of a chronic flulike state.

>

> Influenza patients have overwhelming fatigue, fever, myalgias, and arthalgias.

Common laboratory tests, such as complete blood count, erythrocyte sedimentation

rate, and ANA are normal in individuals with influenza.

>

> It is difficult to document the presence of the virus, although the disease is

diagnosed by physicians in the absence of positive viral cultures. Release of

immune mediators (cytokines) by mononuclear cells is the most likely mechanism

for the presence of constitutional symptoms. A similar circumstance may occur

with the release of cytokines by mononuclear cells ingesting silicone.

>

> The criteria for classification of fibromylagia include generalized pain in

symmetrical areas of the body including those above and below the waist. Also

included is pain with palpation in 11 of 18 tender point sites. Other factors

associated with fibromylagia include nonrestorative sleep, daytime fatigue,

chronic headache, and irritable bowel syndrome. Criteria for chronic fatigue

syndrome include persistent fatigue sufficient to reduce daily activity by 50%

or more for a period over 6 months, along with chills, cervical lymphadenopathy,

headaches, myalgias, sleep disturbance, and fever.

>

> Patients with silicone breast implants have similar but not identical symptoms

associated with these other disorders.

>

> The severity of fatigue and the presence of a limited number of tender points

differentiates this illness from fibromyalgia and chronic fatigue syndrome.

Patients with fibromyalgia associated with siliconosis do not have symmetrical

tender points. Most tender points are located above the waist, and < 11 are

identified in these patients.

>

> Siliconosis also differs from chronic fatigue syndrome. Patients with breast

implants do not have fever, which is a frequent manifestation of chronic fatigue

syndrome. Laboratory tests are normal in chronic fatigue syndrome, whereas a

third of symptomatic patients with silicone breast implants have abnormal

laboratory tests including ANAs.

>

> In addition to the musculoskeletal symptoms associated with siliconosis, a

minority of patients also experience skin rash, alopecia, fever,

lymphadenopathy, and arthritis.

>

> A significant number of patients develop a Sjögren's-like disorder

characterized by xerophthalmia and xerostomia. However, there is an absence of

autoantibodies and cellular infiltrates associated with classic Sjögren's

syndrome.

>

> Systemic lupuslike syndrome may appear with arthralgias, skin rash, and fever

in the absence of detectable ANA.

>

> Rheumatoid arthritis-like disease may be characterized by years of

polyarthritis without significant erosions or periarticular osteopenia.

>

> Neurological symptoms in the form of shortterm memory loss, paresthesias, and

neuropathy have been reported.

>

> The pathogenesis of this disorder remains to be determined.

>

> The report of Kossovsky suggests that the alterations in plasma proteins

facilitate the ingestion of silicone by macrophages that initiate an

immunological response characterized by a chronic inflammatory state that is

associated with the production of autoantibody and cytokines.

>

> The capsule surrounding implants is a potential site for production of a

number of immunologically active factors that could result in patient symptoms.

>

> Inflammatory reaction, including lymphocytes, monocytes, and plasma cells, has

been identified in implant patients, with or without overt leakage.

>

> Increased amounts of interleukin 2 have been detected in capsules surrounding

breast implants. The presence of these factors may explain the reason for the

presence of the syndrome in patients with intact implants.

>

> Clinical symptoms associated with this pathological immunological state may

occur in genetically predisposed patients. Preliminary studies suggest that

genetically predisposed patients may have the DR53 haplotype.

>

> Patients whose implants were removed have reported improvement in symptoms.

> The improvement is not immediate in most patients. Some patients report

improvement that has its onset 12 months or more after explantation.

>

> This time course of improvement does not follow a course expected with placebo

effect.  One would predict that improvement with explantation would be

immediate with placebo effect.

>

> Explantation of the implants, along with the surrounding capsule, removes a

large amount of silicone from the patient. Improvement over 12 months or longer

suggests that an abnormal immune response is decreasing with removal of the

silicone.

> The amount of silicone that remains in patients with enlarged axillary lymph

nodes may not be adequate, over time, to sustain the abnormal immune response.

>

> In some patients, the residual amounts of silicone may be adequate to sustain

the pathological process. This group may contain the third of patients who do

not improve with explantation.

>

> Finally, the current controversy involving silicone breast implants seems

reminiscent of the debate surrounding the original patients with Lyme disease.

The physicians who saw these first patients preferred to diagnose juvenile

rheumatoid arthritis, a disease that they knew. Superficially, the illness

seemed to be juvenile rheumatoid arthritis because it occurred in children and

caused arthritis. However, closer scrutiny revealed that the illness occurred in

clusters and affected adults as well as children. The illness was not juvenile

rheumatoid arthritis, but a new illness caused by Borrelia burgdorferi and

transmitted by a tick (Ixodes dammini).

>

> Our current understanding of silicone breast implants is that silicone is not

inert and has the capability of causing systemic tissue damage. The mechanism by

which this agent results in a clinical disease that differs from other rheumatic

disorders remains to be determined.

>

> The participants of this symposium hope that the data presented will heighten

interest in this condition and result in additional studies to further define

the disease and improve therapies for women who are symptomatic from silicone

breast implants.

>

>

> Article Outline

>

> • References

> Corresponding author. Address reprint requests to Borenstein, MD, 2150

Pennsylvania Avenue, NW, Washington DC 20037.

>

> From the Division of Rheumatology, Department of Medicine, The

Washington University Medical Center, Washington

>

> ScienceDirect - Seminars in Arthritis and Rheumatism : Siliconosis: A spectrum

of illness

>

> http://www.scienced irect.com/ science

>

>

>

> References and further reading may be available for this article. To view

references and further reading you must purchasethis article.

>

>

> ScienceDirect - Seminars in Arthritis and Rheumatism : Siliconosis: A spectrum

of illness

>

>

> ************ **

> Check all of your email inboxes from anywhere on the web. Try the new Email

Toolbar now! (http://toolbar. aol.com/mail/ download. html?ncid=

txtlnkusdown0000 0027)

>

> Borenstein MD, Professor of Medicine

> Available online 13 May 2004.

>

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what a mighty God we serve I excecpt yourr prayerz / open arms thanx for reminding me of hes glory 1401! IJN y.

From: glory2glory1401 <glory2glory1401@...> Sent: Tuesday, March 10, 2009 9:51:19 AMSubject: Re: * * * Siliconosis ( from breast implants ) * * * the best I have ever read ! !

Praying for you Yavon....>> I hate that this stold my lifez focus 2 correct my statement of JUST LIFE as taking of the sickness overwelmbz U with not being able 2 type, speek think ,talk, alsoz I am filing 4 diability?! dont let boobeyz run your life (not take it) I have 2 go lie dowt all this siiting up hs be exoesded thank u 4 the info i kno.......> > > > > ____________ _________ _________ __> From: "DGRAHAMA@.. ." <DGRAHAMA@.. .>> DGrahamA@...> Sent: Sunday, March 8, 2009 2:36:21 PM> Subject: * * * Siliconosis ( from breast implants ) *

* * the best I have ever read ! !> > > > Siliconosis: A spectrum of illness > > Abstract> > The information reported at this symposium presents initial data supporting the notion that patients with exposure to silicone gel are experiencing a new illness.. Previously, this disorder was described variously as “human adjuvant disease� and chronic silicone arthropathy.> > During the symposium, the term siliconosis and silicone implant syndrome (SIMS) was used to describe the clinical syndrome associated with patients receiving silicone gel in liquid or encapsulated form. I prefer the term siliconosis because it is inclusive of symptomatic women who were exposed to silicone gel by injection or implant placement.> > Siliconosis is characterized by a spectrum of illness that may affect a number of organs. In its most common form, siliconosis is a musculoskeletal

pain syndrome characterized by overwhelming fatigue, arthralgias, and myalgias. This form of the illness is reminiscent of a chronic flulike state.> > Influenza patients have overwhelming fatigue, fever, myalgias, and arthalgias. Common laboratory tests, such as complete blood count, erythrocyte sedimentation rate, and ANA are normal in individuals with influenza. > > It is difficult to document the presence of the virus, although the disease is diagnosed by physicians in the absence of positive viral cultures. Release of immune mediators (cytokines) by mononuclear cells is the most likely mechanism for the presence of constitutional symptoms. A similar circumstance may occur with the release of cytokines by mononuclear cells ingesting silicone.> > The criteria for classification of fibromylagia include generalized pain in symmetrical areas of the body including those above and below the waist. Also included is

pain with palpation in 11 of 18 tender point sites. Other factors associated with fibromylagia include nonrestorative sleep, daytime fatigue, chronic headache, and irritable bowel syndrome. Criteria for chronic fatigue syndrome include persistent fatigue sufficient to reduce daily activity by 50% or more for a period over 6 months, along with chills, cervical lymphadenopathy, headaches, myalgias, sleep disturbance, and fever.> > Patients with silicone breast implants have similar but not identical symptoms associated with these other disorders.> > The severity of fatigue and the presence of a limited number of tender points differentiates this illness from fibromyalgia and chronic fatigue syndrome. Patients with fibromyalgia associated with siliconosis do not have symmetrical tender points. Most tender points are located above the waist, and < 11 are identified in these patients. > > Siliconosis also differs

from chronic fatigue syndrome. Patients with breast implants do not have fever, which is a frequent manifestation of chronic fatigue syndrome. Laboratory tests are normal in chronic fatigue syndrome, whereas a third of symptomatic patients with silicone breast implants have abnormal laboratory tests including ANAs.> > In addition to the musculoskeletal symptoms associated with siliconosis, a minority of patients also experience skin rash, alopecia, fever, lymphadenopathy, and arthritis.> > A significant number of patients develop a Sjögren's-like disorder characterized by xerophthalmia and xerostomia. However, there is an absence of autoantibodies and cellular infiltrates associated with classic Sjögren's syndrome.> > Systemic lupuslike syndrome may appear with arthralgias, skin rash, and fever in the absence of detectable ANA. > > Rheumatoid arthritis-like disease may be characterized by

years of polyarthritis without significant erosions or periarticular osteopenia. > > Neurological symptoms in the form of shortterm memory loss, paresthesias, and neuropathy have been reported.> > The pathogenesis of this disorder remains to be determined. > > The report of Kossovsky suggests that the alterations in plasma proteins facilitate the ingestion of silicone by macrophages that initiate an immunological response characterized by a chronic inflammatory state that is associated with the production of autoantibody and cytokines. > > The capsule surrounding implants is a potential site for production of a number of immunologically active factors that could result in patient symptoms. > > Inflammatory reaction, including lymphocytes, monocytes, and plasma cells, has been identified in implant patients, with or without overt leakage.> > Increased amounts of

interleukin 2 have been detected in capsules surrounding breast implants. The presence of these factors may explain the reason for the presence of the syndrome in patients with intact implants. > > Clinical symptoms associated with this pathological immunological state may occur in genetically predisposed patients. Preliminary studies suggest that genetically predisposed patients may have the DR53 haplotype.> > Patients whose implants were removed have reported improvement in symptoms.> The improvement is not immediate in most patients. Some patients report improvement that has its onset 12 months or more after explantation. > > This time course of improvement does not follow a course expected with placebo effect. One would predict that improvement with explantation would be immediate with placebo effect. > > Explantation of the implants, along with the surrounding capsule, removes a

large amount of silicone from the patient. Improvement over 12 months or longer suggests that an abnormal immune response is decreasing with removal of the silicone. > The amount of silicone that remains in patients with enlarged axillary lymph nodes may not be adequate, over time, to sustain the abnormal immune response. > > In some patients, the residual amounts of silicone may be adequate to sustain the pathological process. This group may contain the third of patients who do not improve with explantation.> > Finally, the current controversy involving silicone breast implants seems reminiscent of the debate surrounding the original patients with Lyme disease. The physicians who saw these first patients preferred to diagnose juvenile rheumatoid arthritis, a disease that they knew. Superficially, the illness seemed to be juvenile rheumatoid arthritis because it occurred in children and caused arthritis. However,

closer scrutiny revealed that the illness occurred in clusters and affected adults as well as children. The illness was not juvenile rheumatoid arthritis, but a new illness caused by Borrelia burgdorferi and transmitted by a tick (Ixodes dammini).> > Our current understanding of silicone breast implants is that silicone is not inert and has the capability of causing systemic tissue damage. The mechanism by which this agent results in a clinical disease that differs from other rheumatic disorders remains to be determined. > > The participants of this symposium hope that the data presented will heighten interest in this condition and result in additional studies to further define the disease and improve therapies for women who are symptomatic from silicone breast implants.> > > Article Outline> > • References> Corresponding author. Address reprint requests to Borenstein, MD,

2150 Pennsylvania Avenue, NW, Washington DC 20037.> > From the Division of Rheumatology, Department of Medicine, The Washington University Medical Center, Washington > > ScienceDirect - Seminars in Arthritis and Rheumatism : Siliconosis: A spectrum of illness> > http://www.scienced irect.com/ science> > > > References and further reading may be available for this article. To view references and further reading you must purchasethis article.> > > ScienceDirect - Seminars in Arthritis and Rheumatism : Siliconosis: A spectrum of illness> > > ************ **> Check all of your email inboxes from anywhere on the web. Try the new Email Toolbar now! (http://toolbar. aol.com/mail/ download. html?ncid= txtlnkusdown0000

0027) > > Borenstein MD, Professor of Medicine> Available online 13 May 2004.>

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