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A Patent Pending Proteolytic Enzyme Formula

Date: 08/26/2006

Posted By: Jon Barron

In this alternative health newsletter I want to introduce you to a

new concept in proteolytic enzymes. This represents a reformulation of

my original concept for proteolytic enzymes by combining a unique pH

buffering system with an upgrade in a key enzyme. The formula is so

powerful, so unique, and so effective that it is now patent pending.

For those of you who are familiar with proteolytic enzyme formulas, you

can skip down to "Why pH matters to enzymes." For the

rest of you, before I tell you about the innovations within this new

proteolytic enzyme formula, let's review the basics on systemic,

proteolytic enzyme formulas -- how they help with cellular metabolism,

how they breakdown viruses, bacteria, and proteins, and much more.

Proteolytic enzymes 101

What are enzymes?

Enzymes are proteins that speed up (catalyze) chemical reactions

in living organisms. In fact, they are required for every single

chemical action that takes place in your body. Enzymes run all of your

cells, organs, bones, muscles, and tissues.

Enzymes

allow many chemical reactions to occur within the constraints

(temperature, oxygen levels, acid/alkaline balance, etc.) of a living

system. As organic catalysts, they are involved in, but not changed by,

chemical reactions; and they do not alter the equilibrium of those reactions.

Like all catalysts, enzymes work by providing an alternative pathway of lower activation energy

for a reaction. By bringing the reactants closer together, enzymes can

help make chemical bonds weaker, thus helping reactions proceed faster

than without the catalyst; making reaction many millions of times

faster. This is important since these "reactions" govern every function

in your body, not to mention the destruction of viruses, bacteria, and

cancerous cells.

Without

enzymes, metabolism would progress through the same steps, but would go

too slowly to serve the needs of the cell. In addition, enzymes often

work together in a specific order, creating pathways.

After each enzyme reaction, the product of that reaction is passed on

and used as the raw material (substrate) for another enzyme to work on.

After each enzyme reaction, the product of that reaction is passed on

and used as the raw material (substrate) for another enzyme to work on.

(See a Flash Demo of the process.) Metabolic pathways control cell metabolism.

Cell metabolism is the process (or really the sum of many individual

processes) by which living cells take in nutrients, eliminate waste,

and maintain life.

In essence, enzymes are the stuff of life.

By allowing reactions to happen at far lower energy thresholds, they

make life happen where otherwise there would be none. In the movies, Victor enstein used electricity to create life; he probably would have been better served using enzymes.

Beyond digestion

An important concept to understand is that digestive enzyme formulas and systemic/metabolic proteolytic enzyme formulas, although they may share many of the same enzymes, are not the same thing.

When you take a digestive enzyme formula with your meal, the enzymes work on speeding up the breakdown of the food in your stomach. When you take a proteolytic enzyme formula

between meals, the enzymes do not get stuck working in your stomach.

Instead, they quickly enter your bloodstream. In the bloodstream, they

can help optimize your blood, plus they can also travel to tissues

throughout your body to assist with intelligent, adaptive healing.

Understanding proteolytic enzymes

The

vast majority of metabolic enzymes in the body, the enzymes that

regulate everything from liver function to the immune system, are proteases,

or proteolytic enzymes -- the focus of this alternative health

newsletter. Proteolytic is a catchall phrase for enzymes that

specifically facilitate the chemical breakdown of proteins by breaking

the bonds between the amino acids that make up those proteins.

Proteolytic enzymes occur naturally in all organisms and constitute

1-5% of the gene content. They are polymorphic. The enzyme action they

produce can adapt to meet the current digestive or metabolic needs of

the body. In other words, proteolytic enzymes are able to adapt to the specific needs of their environment, plus they do not harm any healthy cells. Normal living cells are protected against destruction by the inhibitor mechanism.

Proteases are involved in a multitude of physiological reactions from

simple digestion of food proteins to highly regulated cascades (e.g.

the blood clotting cascade, the complementary immune system, apoptosis activation cascade and the invertebrate prophenoloxidase activating cascade).

The

bottom line is a healthy supply of these protein specific enzymes is

essential for sustaining and maintaining optimal health.

Proteolytic enzymes and illness

Just

about everything that makes us sick is either a protein or is protected

by a protein and is therefore subject to control by enzymes.

Bacteria, viruses, yeasts, and fungi are all protected by proteins. Food allergens are all proteins. Cancer cells are protected by proteins.

Proteolytic enzymes have the ability to digest and destroy the protein

based defense shield of each and every one of these pathogens, thereby

leading to their ultimate elimination.

And then there are CIC's (Circulating Immune Complexes).

CIC's start out as extra-large protein molecules (primarily from wheat,

corn, and dairy) that are only partially digested in the small

intestine and are absorbed into the bloodstream. Once in the

bloodstream, the immune system treats them as invaders because they are

too large to be metabolized, provoking an immune reaction. Antibodies

couple with these foreign protein invaders to form CIC's. At first,

these CIC's may be neutralized in the lymphatic system. But over time,

as too many CIC's are created, they overwhelm the body's ability to

eliminate them. They overwhelm the immune system, and they overwhelm

the kidneys. At that point, the body has no choice but to "store" them

in its soft tissues, where the immune system continues to attack them

as allergens causing inflammation and, ultimately, autoimmune disorders.

It is here that proteolytic enzyme supplements come into play. They compensate for your dietary inadequacies and errors

by making their way into your bloodstream, where they set to work

breaking down CIC's in your blood and soft tissues -- eventually

passing the waste out through your kidneys.

And finally, some

proteolytic enzymes such as nattokinase and endonase are very

specialized. They work on specific protein related tasks such as

optimizing blood, reducing pain and inflammation, and cleaning out the

lungs.

Why you need to supplement?

In a perfect world, we would all eat raw (organic) unprocessed foods that are naturally high in active enzymes.

Note

that man is the only animal that cooks his food (or eats processed

foods for that matter). Cooking and processing kills enzymes. In fact,

any sustained heat of approximately 118' F destroys virtually all

enzymes. This means that, for most of us, the food entering our

stomachs is severely enzyme deficient.

But this isn't a perfect world.

Most

people eat food that is enzyme deficient and fail to chew food

adequately so their bodies must compensate. The body is forced to divert

its production of enzymes away from proteolytic enzymes, which govern

metabolic functions, into digestive enzymes designed to break down dead

proteins in our diets. The consequences of this diversion are enormous.

It can lead to everything from a weakened immune system to thickened

blood, from pain and inflammation to cardiovascular disease, and from

difficulty breathing to reduced athletic endurance. Supplementing with proteolytic enzymes offsets this devastating diversion.

Why pH matters to enzymes

As

I mentioned at the top of the newsletter, the big breakthrough in this

new enzyme concept is in the addition of a pH buffering system. But why

does pH matter to enzymes?

Although pH is in actuality a

measure of the degree of Hydrogen (H) ions in a substance or solution,

it is best recognized as a measure of the acid/alkaline balance of

anything. (0-7 is acid; 7 is neutral; 7-14 is alkaline or base.) In

another sense, though, it is also a measure of the available (unbound)

oxygen in something -- the higher the pH, the more available oxygen

there is in your body. A proper alkaline environment in your blood

provides literally thousands of times the oxygen needed for all bodily

functions. Proper pH by itself is a major factor in optimizing health

and preventing disease (cancer, for example, thrives in an acid

environment), but it also directly impacts the efficacy of proteolytic

enzymes in your body.

"Enzymes function optimally at a specific pH and become inactive if this deviates beyond narrow limits," - Anatomy and Physiology by and Thibodeau.

Think

of it this way. There are hundreds if not thousands of enzyme processes

that take place in the body. Many are so specific that they are like

complex square pegs that need to "fit" into specific square holes in

order to carry out their function. If pH is off-balance even a little,

some important pegs will not "fit" into their respective slots. Enzyme

function and thus life itself begins to suffer.

Not

surprisingly then, different pH's are required to optimize different

body functions. For example, your saliva is slightly alkaline, whereas

your stomach juices are strongly acidic. Your intestines operate best

in a strongly alkaline environment, and your urine prefers a more

acidic environment for control of bacteria. The most important pH of

all, however, is your blood pH, because a deviation of as little as

5/10th of a point from its normal pH of 7.45 can result in illness or

death.

That said, small deviations of less than

1/10th of a point can make a huge difference in your health and in the

effectiveness of the proteolytic enzymes that operate in your blood.

The bottom line is that, in general, the higher the pH in your blood,

the more active the enzymes. This has implications for everything from

boosting your immune system to your ability to utilize oxygen.

When

it comes to proteolytic enzymes, most proteolytic enzymes (other than

pepsin) work best in a neutral to slightly alkaline environment.

Optimizing that environment, then, becomes crucial for good health.

What changes your body's pH?

When

you metabolize carbohydrates, proteins, and fats, various acids are

produced. Proteins, for example, produce sulfuric acid and phosphoric

acid. Carbohydrates and fats produce acetic acid and lactic acid. The

bottom line is that diet changes your body's pH. And most of us eat a

highly acidic diet (meat, dairy, cooked grains, and most bottled

drinks).

Why Minerals are important.

There

are complex biochemical processes constantly working to keep your pH

levels optimized for maximum enzyme activity. These are known as pH

buffering systems. They are mineral based. If you lack minerals in your

diet (common in modern diets), then your body's natural buffering

system is deficient.

Essentially, your body uses minerals

such as sodium, calcium, potassium, and magnesium to combine with the

acids and turn them into pH neutral mineral salts. These salts can then

be safely eliminated through your kidneys.

An enzyme epiphany

We

have talked about how important an optimal pH environment is to the

effectiveness of proteolytic enzymes. CMIK-pH+ (a proprietary blend of

calcium, magnesium, ionic trace minerals, and potassium that has been

added to this new proteolytic enzyme formula) creates just such an

environment -- and a whole lot more.

First, it

provides extra protection for the enzymes from stomach acid. Normally,

if you take your proteolytic enzymes on an empty stomach, the acid

content is fairly low so they don't suffer much damage anyway --

particularly if you choose your enzymes carefully. This was one of the

reasons for using Seaprose-S instead of serrapeptase in the formula.

Nevertheless, it provides that "extra level" of protection. (Note:

enteric coating is a pretty marginal technology when it comes to

capsules. It doesn't really protect the enzymes very well.) It

helps optimize the pH of the blood. Again, as said previously, blood pH

will vary very little to protect against death. However, as also

stated, minor changes in blood pH make a huge difference in proteolytic

enzyme efficiency and oxygen availability. The impact of CMIK-pH+ in

this regard is monumental. It helps optimize the pH

of all your soft tissue. Since your body will do anything to keep your

blood's pH in a narrow range, that means it robs to pay . It

steals minerals and lowers pH in your soft tissue to protect your blood

if your diet is too acidic. And if you eat meat, dairy, cooked grains,

desserts, and most fruit, then your diet is indeed too acidic. Bottom

line here is that by raising soft tissue pH, you dramatically improve

the ability of proteolytic enzymes to root out CIC's embedded in that

soft tissue, thus relieving allergies and reducing the possibility of

autoimmune conditions. And finally, by providing a

source of buffering minerals, CMIK-pH+ reduces the chances of

osteoporosis. After all, if your body needs minerals to buffer a high

acid diet, what's the biggest mineral bank in your body? Your bones!

The presence of CMIK-pH+ can help offset some (or all) of that need,

depending on how many capsules of the formula you take, so you keep

minerals in your bones for strength.

The addition of CMIK-pH+ to a proteolytic enzyme formula is so revolutionary and so effective, it is now patent pending.

Upgrade in key enzyme

We have talked before about the powerful ingredients used in the original Proteolytic Enzyme formula. In this newsletter I want to update you on a change we made in one of the key enzymes, Seaprose-S.

Seaprose-S

was integral to the original formula because of its remarkable

anti-inflammatory and anti-fluid retention activity. In addition to

reducing inflammation, it has a profound ability to reduce pain, clear

mucous from the lungs, and break down sputum in patients with chronic

airway diseases. And unlike serrapeptase, it is not affected by stomach

acid so it does not require enteric coating. It is also much less

upsetting to the stomach.

But from a manufacturing point of

view, it is like a high-strung racehorse -- difficult to work with. So

I looked for an alternative (for over a year) before discovering

Endonase� (aka Protease-S).

Endonase has all of the

benefits of Seaprose-S (and is in fact closely related to it), but

offers the advantage of being less concentrated so it's much easier to

work with in manufacturing, resulting in a much more consistent final

formulation.

Bottom line: Endonase allows us to get all of the benefits of Seaprose-S, but with much more precise tuning. For that reason, I replaced Seaprose-S with Endonase in the new formulation.

Proteolytic enzymes and health

With

an understanding of how your body utilizes proteolytic enzymes, what

interferes with their potential (an acid body), and what maximizes

their potential (an alkaline body), it becomes clear that the

advantages of supplementing with a good systemic proteolytic enzyme

formula with an added pH buffering system are profound. Possible

benefits include:

Reduce inflammation for:

Increased heart health, Cancer prevention and recovery, Alzheimer's

prevention, Fibromyalgia, Chronic fatigue, and more Cleanse the blood of debris Break down and remove Circulating Immune Complexes Dissolve arterial plaque Dissolve fibrin in the blood, reducing the risk of clots Eliminating the risk of DVT (Deep Vein Thrombosis) Boosting the immune system Kill bacteria and viruses Improve circulation Eliminate autoimmune diseases Speed up recovery from sprains, strains, fractures, bruises, contusions, and surgery Speed up recovery time from workouts Help with MS Help with arthritis Remove plaque from teeth Help with sinusitis and asthma Dissolve scar tissue Aid in detoxing Improved body alkalinity Reduced risk of osteoporosis

Conclusion

From

removing dental plaque to protecting your cardiovascular system, from

reducing inflammation throughout the entire body to speeding up the

recovery times of athletes, the bottom line is that supplementation

with a good proteolytic enzyme formula such as we've discussed here

today is essential.

In addition:

Add more raw foods to your diet. Cut out (or at least cut down) processed foods. Cut out (or at least cut down) cooked foods. Chew your food properly. Drink alkalinized water.

PS:

A

couple of years ago, we issued a challenge to dentists to validate the

ability of systemic proteolytic enzymes to dissolve plaque. As far as I

know, no dentist has ever taken up the challenge -- but some of our

readers have

"Five months ago I had my

teeth cleaned. At that time I had the expected, usual amount of plaque

on my teeth. So the hygienist cleaned it up. One month ago I began

taking the Proteolytic Enzymes for some joint

inflammation I was experiencing after taking a round of antibiotics for

a strong kidney infection. With the help of the Proteolytics, the pain

went away very quickly, as I thought it would. Then 2 days ago, I went

to the dentist again to have my teeth cleaned and sealed. The hygienist

said I did not need my teeth cleaned because there was no plaque on my

teeth at all!"

Caitlin W., OH

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