RE: Why do some diabetics not get complications

January 25, 2011

very educational article, then Nurse , just love your articles, they

have helped me in the past

keep it up

sugar

Steelers All The Way!!

~Sugar

Why do some diabetics not get complications

Why Do Some Diabetics Escape Complications?

ScienceDaily (Jan. 23, 2011) - Much research has been carried out on why

diabetics develop complications. Now researchers are asking the question the

other way around. They want to know why some diabetic patients do not

develop complications. What is it that protects them? The PROLONG study

could provide the answer.

_____

explains Valeriya Lyssenko, who along with Nilsson, both from Lund

University Diabetes Centre, leads the PROLONG (PROLONG stands for PROtective

genes in diabetes and LONGevity) study.

Stiff sugary arteries

Major diabetic complications include kidney disease (nephropathy), eye

damage (retinopathy), heart attacks and stroke. Despite decades of intensive

research on diabetes complications, the fundamental mechanisms are not yet

fully known. Neither is it possible to prevent or treat the damage to the

blood vessels that affects the majority of diabetics.

The risk of dying from cardiovascular disease is two to three times higher

for diabetics than for non-diabetics. The small blood vessels are also

damaged. After only ten years with diabetes, 70 per cent of patients will

have some form of kidney damage that may progress to kidney failure. As many

suffer from eye complications -- some will develop severe visual impairment

and two per cent will become blind.

" The blood vessels and other organs of the body become sugar coated and

stiff. It is reminiscent of premature biological ageing, " says

Nilsson.

Half of the veterans

Perhaps nature itself can answer the question of why some patients are

protected. This is what the PROLONG study will investigate.

Today there are approximately 12 000 people in Sweden who have had diabetes

for more than 30 years; of these, 1 600 have had it for over 50 years.

" About half of these diabetic veterans do not have major complications. Two

thirds of those who have had diabetes for more than 50 years have escaped

complications. Clearly they are different and we want to find out what it is

that protects them, " says Valeriya Lyssenko.

Greatest risk passed after 30 years

The PROLONG study is starting now in Skåne with a pilot study of patients

with diabetes duration of more than 30 years. At a later stage patients will

be recruited from all hospitals and health care centres in Sweden. They will

be compared with diabetics who have already developed severe complications

despite having had diabetes for less than 15 years.

The 30-year limit has been chosen because a person who has had diabetes for

such a long time without developing complications is unlikely to do so later

in life.

Copying nature's protective mechanisms

Participants in the PROLONG study will answer questions about their

lifestyle and about diseases they, or their closest relatives, may have.

Various blood samples, including genetic tests, will be analysed, and close

relatives of the participants will also be invited to take part in the

study.

" If we can identify factors protecting these veterans from devastating

complications, then it might be possible to develop drugs that can do the

same thing, " says Valeriya Lyssenko.

January 25, 2011

I wonder if the correlation is that people who have had diabetes for more than

30 years, with few or no problems, have simply taken care of their diabetes

better.

Thanks, Pat.

Dave

--

Weather conditions on 1/24/2011 9:33:22 PM in Lancaster, Pennsylvania

Overcast, 23.0°F Wind:SSE-150° at 6mph

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Why do some diabetics not get complications

Why Do Some Diabetics Escape Complications?

ScienceDaily (Jan. 23, 2011) - Much research has been carried out on why

diabetics develop complications. Now researchers are asking the question the

other way around. They want to know why some diabetic patients do not

develop complications. What is it that protects them? The PROLONG study

could provide the answer.

_____

explains Valeriya Lyssenko, who along with Nilsson, both from Lund

University Diabetes Centre, leads the PROLONG (PROLONG stands for PROtective

genes in diabetes and LONGevity) study.

Stiff sugary arteries

Major diabetic complications include kidney disease (nephropathy), eye

damage (retinopathy), heart attacks and stroke. Despite decades of intensive

research on diabetes complications, the fundamental mechanisms are not yet

fully known. Neither is it possible to prevent or treat the damage to the

blood vessels that affects the majority of diabetics.

The risk of dying from cardiovascular disease is two to three times higher

for diabetics than for non-diabetics. The small blood vessels are also

damaged. After only ten years with diabetes, 70 per cent of patients will

have some form of kidney damage that may progress to kidney failure. As many

suffer from eye complications -- some will develop severe visual impairment

and two per cent will become blind.

" The blood vessels and other organs of the body become sugar coated and

stiff. It is reminiscent of premature biological ageing, " says

Nilsson.

Half of the veterans

Perhaps nature itself can answer the question of why some patients are

protected. This is what the PROLONG study will investigate.

Today there are approximately 12 000 people in Sweden who have had diabetes

for more than 30 years; of these, 1 600 have had it for over 50 years.

" About half of these diabetic veterans do not have major complications. Two

thirds of those who have had diabetes for more than 50 years have escaped

complications. Clearly they are different and we want to find out what it is

that protects them, " says Valeriya Lyssenko.

Greatest risk passed after 30 years

The PROLONG study is starting now in Skåne with a pilot study of patients

with diabetes duration of more than 30 years. At a later stage patients will

be recruited from all hospitals and health care centres in Sweden. They will

be compared with diabetics who have already developed severe complications

despite having had diabetes for less than 15 years.

The 30-year limit has been chosen because a person who has had diabetes for

such a long time without developing complications is unlikely to do so later

in life.

Copying nature's protective mechanisms

Participants in the PROLONG study will answer questions about their

lifestyle and about diseases they, or their closest relatives, may have.

Various blood samples, including genetic tests, will be analysed, and close

relatives of the participants will also be invited to take part in the

study.

" If we can identify factors protecting these veterans from devastating

complications, then it might be possible to develop drugs that can do the

same thing, " says Valeriya Lyssenko.

January 25, 2011

Dave,

I wonder this, too. I also wonder if the statement that 70% of diabetics

have some degree of kidney damage after 10 years is true, or whether

this is based on statistics from 30 or 40 years ago. A diabetic

diagnosed 10 years ago would have been diagnosed in 2000 or 2001 when

all the insulin analogues, insulin pumps, multiple daily injections,

carbohydrate counting, diabetes management software, and so on were

available. Unless they totally ignored their diabetes, I find it hard to

believe 70% will have kidney damage today using all those tools

properly. I truly believe that kids being diagnosed today who are put on

pumps and continuous glucose monitors within a year of diagnosis may

live their entire lives without ever getting complications as long as

they take full advantage of those tools.

I personally count myself lucky to have no signs of complications after

nearly 20 years of Type 1, but then I have also had pretty good control

all my life. Not fantastically, super, ultra-tight control, but decent

control. I never even really went through the usual " rebellion " stage as

a teenager or young adult. And maybe I shouldn't speak too soon, since I

am getting my yearly bloodwork done in a few weeks!

Jen

>

> I wonder if the correlation is that people who have had diabetes for

> more than 30 years, with few or no problems, have simply taken care of

> their diabetes better.

>

> Thanks, Pat.

>

> Dave

>

January 25, 2011

That is certainly true, but I have met some diabetics who have not taken

very good care of their disease and still do not have any problems. It is

somewhat of a mystery to me.

_____

From: blind-diabetics

[mailto:blind-diabetics ] On Behalf Of dave Bond

Sent: Monday, January 24, 2011 6:38 PM

To: blind-diabetics

Subject: Re: Why do some diabetics not get complications

I wonder if the correlation is that people who have had diabetes for more

than 30 years, with few or no problems, have simply taken care of their

diabetes better.

Thanks, Pat.

Dave

--

Weather conditions on 1/24/2011 9:33:22 PM in Lancaster, Pennsylvania

Overcast, 23.0°F Wind:SSE-150° at 6mph

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Why do some diabetics not get complications

Why Do Some Diabetics Escape Complications?

ScienceDaily (Jan. 23, 2011) - Much research has been carried out on why

diabetics develop complications. Now researchers are asking the question the

other way around. They want to know why some diabetic patients do not

develop complications. What is it that protects them? The PROLONG study

could provide the answer.

_____

explains Valeriya Lyssenko, who along with Nilsson, both from Lund

University Diabetes Centre, leads the PROLONG (PROLONG stands for PROtective

genes in diabetes and LONGevity) study.

Stiff sugary arteries

Major diabetic complications include kidney disease (nephropathy), eye

damage (retinopathy), heart attacks and stroke. Despite decades of intensive

research on diabetes complications, the fundamental mechanisms are not yet

fully known. Neither is it possible to prevent or treat the damage to the

blood vessels that affects the majority of diabetics.

The risk of dying from cardiovascular disease is two to three times higher

for diabetics than for non-diabetics. The small blood vessels are also

damaged. After only ten years with diabetes, 70 per cent of patients will

have some form of kidney damage that may progress to kidney failure. As many

suffer from eye complications -- some will develop severe visual impairment

and two per cent will become blind.

" The blood vessels and other organs of the body become sugar coated and

stiff. It is reminiscent of premature biological ageing, " says

Nilsson.

Half of the veterans

Perhaps nature itself can answer the question of why some patients are

protected. This is what the PROLONG study will investigate.

Today there are approximately 12 000 people in Sweden who have had diabetes

for more than 30 years; of these, 1 600 have had it for over 50 years.

" About half of these diabetic veterans do not have major complications. Two

thirds of those who have had diabetes for more than 50 years have escaped

complications. Clearly they are different and we want to find out what it is

that protects them, " says Valeriya Lyssenko.

Greatest risk passed after 30 years

The PROLONG study is starting now in Skåne with a pilot study of patients

with diabetes duration of more than 30 years. At a later stage patients will

be recruited from all hospitals and health care centres in Sweden. They will

be compared with diabetics who have already developed severe complications

despite having had diabetes for less than 15 years.

The 30-year limit has been chosen because a person who has had diabetes for

such a long time without developing complications is unlikely to do so later

in life.

Copying nature's protective mechanisms

Participants in the PROLONG study will answer questions about their

lifestyle and about diseases they, or their closest relatives, may have.

Various blood samples, including genetic tests, will be analysed, and close

relatives of the participants will also be invited to take part in the

study.

" If we can identify factors protecting these veterans from devastating

complications, then it might be possible to develop drugs that can do the

same thing, " says Valeriya Lyssenko.

January 25, 2011

I have also met diabetics who have taken very good care and still ended up

with complications!

Why do some diabetics not get complications

Why Do Some Diabetics Escape Complications?

ScienceDaily (Jan. 23, 2011) - Much research has been carried out on why

diabetics develop complications. Now researchers are asking the question

the

other way around. They want to know why some diabetic patients do not

develop complications. What is it that protects them? The PROLONG study

could provide the answer.

_____

explains Valeriya Lyssenko, who along with Nilsson, both from Lund

University Diabetes Centre, leads the PROLONG (PROLONG stands for

PROtective

genes in diabetes and LONGevity) study.

Stiff sugary arteries

Major diabetic complications include kidney disease (nephropathy), eye

damage (retinopathy), heart attacks and stroke. Despite decades of

intensive

research on diabetes complications, the fundamental mechanisms are not yet

fully known. Neither is it possible to prevent or treat the damage to the

blood vessels that affects the majority of diabetics.

The risk of dying from cardiovascular disease is two to three times higher

for diabetics than for non-diabetics. The small blood vessels are also

damaged. After only ten years with diabetes, 70 per cent of patients will

have some form of kidney damage that may progress to kidney failure. As

many

suffer from eye complications -- some will develop severe visual

impairment

and two per cent will become blind.

" The blood vessels and other organs of the body become sugar coated and

stiff. It is reminiscent of premature biological ageing, " says

Nilsson.

Half of the veterans

Perhaps nature itself can answer the question of why some patients are

protected. This is what the PROLONG study will investigate.

Today there are approximately 12 000 people in Sweden who have had

diabetes

for more than 30 years; of these, 1 600 have had it for over 50 years.

" About half of these diabetic veterans do not have major complications.

Two

thirds of those who have had diabetes for more than 50 years have escaped

complications. Clearly they are different and we want to find out what it

is

that protects them, " says Valeriya Lyssenko.

Greatest risk passed after 30 years

The PROLONG study is starting now in Skåne with a pilot study of patients

with diabetes duration of more than 30 years. At a later stage patients

will

be recruited from all hospitals and health care centres in Sweden. They

will

be compared with diabetics who have already developed severe complications

despite having had diabetes for less than 15 years.

The 30-year limit has been chosen because a person who has had diabetes

for

such a long time without developing complications is unlikely to do so

later

in life.

Copying nature's protective mechanisms

Participants in the PROLONG study will answer questions about their

lifestyle and about diseases they, or their closest relatives, may have.

Various blood samples, including genetic tests, will be analysed, and

close

relatives of the participants will also be invited to take part in the

study.

" If we can identify factors protecting these veterans from devastating

complications, then it might be possible to develop drugs that can do the

same thing, " says Valeriya Lyssenko.

January 25, 2011

I'd like to share a few thoughts on science and

the practical treatment of diabetes. I have done

a good deal of research on the philosophy of

science in my graduate studied in political

science. I have a Ph.D. in political science. I

do not say this to toot my own horn, but to say

that I have some expertise in this area.

The treatment of diabetes is approached by the

medical profession on a scientific basis which

assumes a mechanical cause and effect

relationship. You and I know that the treatment

of diabetes at a practical level is not a

mechanical one but a stocastic model of cause and

effect, which is one that involves chance and

probability. You do the same thing today that

you did yesterday for the same conditions and

under the same circumstances and get a different

result. This is most exasperating, but it is the

way it is. Hopefully, we learn to adjust and

deal with these unexpected conditions.

When dealing with diabetic complications, we need

to look at probability of result. let's assume

that 70% of people who kept their A1C between 6.0

and 7.0 have fewer complications than those whose

A1Cs were higher than 7.0. . If I knew that 7

out of ten dogs that came into my yard would not

bite and would help to clear it of moles and 28%

of the rest would not bite, then I would welcome

dogs into my yard. So I think the probability of

avoiding complication from diabetes are better if

I keep my A1C below 7.0. It helps to keep from

becoming discouraged and too hard on ourselves to

remember that You can never derive a universal

truth from experience because experience is never

universal. We can take encouragement, however,

from being responsible, paying attention to our

bodies and conditions, and learning from our

successes and failures and from those on the

blind diabetic list and our health care providers as well.

Danny

At 05:04 AM 1/25/2011, you wrote:

>

>I have also met diabetics who have taken very good care and still ended up

>with complications!

> Why do some diabetics not get complications

>

>Why Do Some Diabetics Escape Complications?

>

>ScienceDaily (Jan. 23, 2011) - Much research has been carried out on why

>diabetics develop complications. Now researchers are asking the question

>the

>other way around. They want to know why some diabetic patients do not

>develop complications. What is it that protects them? The PROLONG study

>could provide the answer.

>

>_____

>

>explains Valeriya Lyssenko, who along with Nilsson, both from Lund

>University Diabetes Centre, leads the PROLONG (PROLONG stands for

>PROtective

>genes in diabetes and LONGevity) study.

>

>Stiff sugary arteries

>

>Major diabetic complications include kidney disease (nephropathy), eye

>damage (retinopathy), heart attacks and stroke. Despite decades of

>intensive

>research on diabetes complications, the fundamental mechanisms are not yet

>fully known. Neither is it possible to prevent or treat the damage to the

>blood vessels that affects the majority of diabetics.

>

>The risk of dying from cardiovascular disease is two to three times higher

>for diabetics than for non-diabetics. The small blood vessels are also

>damaged. After only ten years with diabetes, 70 per cent of patients will

>have some form of kidney damage that may progress to kidney failure. As

>many

>suffer from eye complications -- some will develop severe visual

>impairment

>and two per cent will become blind.

>

> " The blood vessels and other organs of the body become sugar coated and

>stiff. It is reminiscent of premature biological ageing, " says

>Nilsson.

>

>Half of the veterans

>

>Perhaps nature itself can answer the question of why some patients are

>protected. This is what the PROLONG study will investigate.

>

>Today there are approximately 12 000 people in Sweden who have had

>diabetes

>for more than 30 years; of these, 1 600 have had it for over 50 years.

>

> " About half of these diabetic veterans do not have major complications.

>Two

>thirds of those who have had diabetes for more than 50 years have escaped

>complications. Clearly they are different and we want to find out what it

>is

>that protects them, " says Valeriya Lyssenko.

>

>Greatest risk passed after 30 years

>

>The PROLONG study is starting now in Skåne with a pilot study of patients

>with diabetes duration of more than 30 years. At a later stage patients

>will

>be recruited from all hospitals and health care centres in Sweden. They

>will

>be compared with diabetics who have already developed severe complications

>despite having had diabetes for less than 15 years.

>

>The 30-year limit has been chosen because a person who has had diabetes

>for

>such a long time without developing complications is unlikely to do so

>later

>in life.

>

>Copying nature's protective mechanisms

>

>Participants in the PROLONG study will answer questions about their

>lifestyle and about diseases they, or their closest relatives, may have.

>Various blood samples, including genetic tests, will be analysed, and

>close

>relatives of the participants will also be invited to take part in the

>study.

>

> " If we can identify factors protecting these veterans from devastating

>complications, then it might be possible to develop drugs that can do the

>same thing, " says Valeriya Lyssenko.

>

January 25, 2011

Well stated. I must say though, to use a cliché, there are indeed exceptions to

every rule. Mystery cases where someone pays little attention to treatment and

yet is in good health. But these are rare cases I suggest.

Dave

--

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Overcast, 26.1°F Wind:Calm

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Why do some diabetics not get complications

>

>Why Do Some Diabetics Escape Complications?

>

>ScienceDaily (Jan. 23, 2011) - Much research has been carried out on why

>diabetics develop complications. Now researchers are asking the question

>the

>other way around. They want to know why some diabetic patients do not

>develop complications. What is it that protects them? The PROLONG study

>could provide the answer.

>

>_____

>

>explains Valeriya Lyssenko, who along with Nilsson, both from Lund

>University Diabetes Centre, leads the PROLONG (PROLONG stands for

>PROtective

>genes in diabetes and LONGevity) study.

>

>Stiff sugary arteries

>

>Major diabetic complications include kidney disease (nephropathy), eye

>damage (retinopathy), heart attacks and stroke. Despite decades of

>intensive

>research on diabetes complications, the fundamental mechanisms are not yet

>fully known. Neither is it possible to prevent or treat the damage to the

>blood vessels that affects the majority of diabetics.

>

>The risk of dying from cardiovascular disease is two to three times higher

>for diabetics than for non-diabetics. The small blood vessels are also

>damaged. After only ten years with diabetes, 70 per cent of patients will

>have some form of kidney damage that may progress to kidney failure. As

>many

>suffer from eye complications -- some will develop severe visual

>impairment

>and two per cent will become blind.

>

> " The blood vessels and other organs of the body become sugar coated and

>stiff. It is reminiscent of premature biological ageing, " says

>Nilsson.

>

>Half of the veterans

>

>Perhaps nature itself can answer the question of why some patients are

>protected. This is what the PROLONG study will investigate.

>

>Today there are approximately 12 000 people in Sweden who have had

>diabetes

>for more than 30 years; of these, 1 600 have had it for over 50 years.

>

> " About half of these diabetic veterans do not have major complications.

>Two

>thirds of those who have had diabetes for more than 50 years have escaped

>complications. Clearly they are different and we want to find out what it

>is

>that protects them, " says Valeriya Lyssenko.

>

>Greatest risk passed after 30 years

>

>The PROLONG study is starting now in Skåne with a pilot study of patients

>with diabetes duration of more than 30 years. At a later stage patients

>will

>be recruited from all hospitals and health care centres in Sweden. They

>will

>be compared with diabetics who have already developed severe complications

>despite having had diabetes for less than 15 years.

>

>The 30-year limit has been chosen because a person who has had diabetes

>for

>such a long time without developing complications is unlikely to do so

>later

>in life.

>

>Copying nature's protective mechanisms

>

>Participants in the PROLONG study will answer questions about their

>lifestyle and about diseases they, or their closest relatives, may have.

>Various blood samples, including genetic tests, will be analysed, and

>close

>relatives of the participants will also be invited to take part in the

>study.

>

> " If we can identify factors protecting these veterans from devastating

>complications, then it might be possible to develop drugs that can do the

>same thing, " says Valeriya Lyssenko.

>

January 25, 2011

I tend to agree, Jen. I believe that newly diagnosed diabetics (and, going back

at least a decade as well) can expect to live long lives if they use the tools,

as you put it. Diagnosed in 1967, at the age of 11, there were virtually no

tools to help me (or any diabetic). IF there is one bright spot to being

diagnosed with diabetes today, it's that there are all these resources and

" tools " to make coping with diabetes a reasonably profitable experience.

Dave

--

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Overcast, 26.1°F Wind:Calm

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Re: Why do some diabetics not get complications