Re: Iodine as a fever reducer

February 19, 2011

Eggs are high biotin. You know where this conversation is going. :-)

Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+ temps. To make a long story short (ha, which is virtually impossible for me to do) -- we put a patch of iodine on his back (between his shoulder blades), and within 20 min, his fever reduced to around 99-100 degrees. He still has a low grade fever (which is fine)

We haven't used motrin or tylenol, and we managed to keep him hydrated. He acts 'normal' during the day, and he usually gets the high fever at night.

Today he has 'post nasal drip' (no green anything) and has a productive cough...

Here's the kicker...no jargon. Completely with it, and super calm and intelligent thoughts, sentences, and thought processes -- he's so with it, and so put together (even for typical kids - and I would go as far to say 'better' than a typical child)--but he sounds like crap. The only other 'annoying' thing is - he is consistently wetting the bed (which is just a laundry issue.) I have upped his supps, but it's still happening. (normally, this goes away when these are upped)

(and yes, I'm now juicing for him all day because that is what he is asking for. Ate 3 eggs this morning, and wanted more. But this is all he will eat. He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

thoughts?

laura

-- Toni------Mind like a steel trap...Rusty and illegal in 37 states.

February 19, 2011

I adore you Toni!! Yes, I know where it's going. He has been low ox for two

days. Except this morning, I gave him beets in his juicer drink. (he got

calcium citrate 20 min prior)

No rash on face. (this is good!)

Viral kid and maybe I have been in denial for 1.5 years?

laura

>

> >

> > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > temps. To make a long story short (ha, which is virtually impossible for me

> > to do) -- we put a patch of iodine on his back (between his shoulder

> > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > still has a low grade fever (which is fine)

> >

> > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > acts 'normal' during the day, and he usually gets the high fever at night.

> >

> > Today he has 'post nasal drip' (no green anything) and has a productive

> > cough...

> >

> > Here's the kicker...no jargon. Completely with it, and super calm and

> > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > and so put together (even for typical kids - and I would go as far to say

> > 'better' than a typical child)--but he sounds like crap. The only other

> > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > laundry issue.) I have upped his supps, but it's still happening. (normally,

> > this goes away when these are upped)

> >

> > (and yes, I'm now juicing for him all day because that is what he is asking

> > for. Ate 3 eggs this morning, and wanted more. But this is all he will eat.

> > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> >

> > thoughts?

> >

> > laura

> >

>

> --

> Toni

>

> ------

> Mind like a steel trap...

> Rusty and illegal in 37 states.

>

February 19, 2011

I feel like there are layers. You had to fix his nutrition before you can fix the viruses. Mitochondria not working right, how can you eliminate viruses?

I adore you Toni!! Yes, I know where it's going. He has been low ox for two days. Except this morning, I gave him beets in his juicer drink. (he got calcium citrate 20 min prior)

No rash on face. (this is good!)

Viral kid and maybe I have been in denial for 1.5 years?

laura-- Toni------Mind like a steel trap...Rusty and illegal in 37 states.

February 19, 2011

Eggs are high in sulfer, too.

Nasal drip is reported in just about everyone that begins iodine

supplementation. I think its the nose clearing out all the gunk that iodine

deficiency has allowed it to accumulate. Or it could just be the histamine

reaction from die off/dead bugs. It goes away.

Iodine was the first treatment of choice back in the olden days for fever.

Tylenol should never be used. Ever. Bad stuff. Sure it reduces the fever, but

also reduces Glutathione.

If the bedwetting is new. It may be virus and bacteria that have gotten into his

bladder/ureters on the way out.

Cheryl

>

> >

> > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > temps. To make a long story short (ha, which is virtually impossible for me

> > to do) -- we put a patch of iodine on his back (between his shoulder

> > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > still has a low grade fever (which is fine)

> >

> > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > acts 'normal' during the day, and he usually gets the high fever at night.

> >

> > Today he has 'post nasal drip' (no green anything) and has a productive

> > cough...

> >

> > Here's the kicker...no jargon. Completely with it, and super calm and

> > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > and so put together (even for typical kids - and I would go as far to say

> > 'better' than a typical child)--but he sounds like crap. The only other

> > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > laundry issue.) I have upped his supps, but it's still happening. (normally,

> > this goes away when these are upped)

> >

> > (and yes, I'm now juicing for him all day because that is what he is asking

> > for. Ate 3 eggs this morning, and wanted more. But this is all he will eat.

> > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> >

> > thoughts?

> >

> > laura

February 19, 2011

I agree. My husband was caught off guard with the fever (as it was high) -- and

went into panic mode, thank goodness, I kept a clear head. Jimmy asked for a

bath because he was hot. I have always trusted his 'instinct' -- and we did

that too. I had thrown out our tylenol, but I did have motrin (dye free) on

hand.

So, we have putting this patch on him for two days - how long should I continue

(in your opinion?)

I have done a patch test on myself, it's completely gone within 3 hours, with

Jimmy, his is very very 'light' but it's still there after 24 hours. I thought

that the skin vs drops would be safer, I guess? I don't know, I am very new to

the iodine stuff...could you post some good places to go to read? or a book?

Thanks for the constant on the thread, I would have NEVER thought of iodine as a

solution to a high fever -- and during the panic, I remembered and -- I thought

" IODINE! " My husband, couldn't believe it, (he said it was the bath) but the

second night, no bath, just iodine, same results. He's a believer....

laura

> >

> > >

> > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > temps. To make a long story short (ha, which is virtually impossible for

me

> > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > > still has a low grade fever (which is fine)

> > >

> > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > > acts 'normal' during the day, and he usually gets the high fever at night.

> > >

> > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > cough...

> > >

> > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > > and so put together (even for typical kids - and I would go as far to say

> > > 'better' than a typical child)--but he sounds like crap. The only other

> > > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > this goes away when these are upped)

> > >

> > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

eat.

> > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > >

> > > thoughts?

> > >

> > > laura

>

February 19, 2011

PANDAS, bed wetting fits is, obsessions fit it, the fever fits is,

From: Toni Marie Lombardo

Sent: Saturday, February 19, 2011 11:39 AM

To: mb12 valtrex

Subject: Re: Iodine as a fever reducer

Eggs are high biotin. You know where this conversation is going. :-)

Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+ temps. To make a long story short (ha, which is virtually impossible for me to do) -- we put a patch of iodine on his back (between his shoulder blades), and within 20 min, his fever reduced to around 99-100 degrees. He still has a low grade fever (which is fine)We haven't used motrin or tylenol, and we managed to keep him hydrated. He acts 'normal' during the day, and he usually gets the high fever at night. Today he has 'post nasal drip' (no green anything) and has a productive cough...Here's the kicker...no jargon. Completely with it, and super calm and intelligent thoughts, sentences, and thought processes -- he's so with it, and so put together (even for typical kids - and I would go as far to say 'better' than a typical child)--but he sounds like crap. The only other 'annoying' thing is - he is consistently wetting the bed (which is just a laundry issue.) I have upped his supps, but it's still happening. (normally, this goes away when these are upped)(and yes, I'm now juicing for him all day because that is what he is asking for. Ate 3 eggs this morning, and wanted more. But this is all he will eat. He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.) thoughts? laura

-- Toni------Mind like a steel trap...Rusty and illegal in 37 states.

February 19, 2011

You know, I never thought my kid was a PANDAS one..so I tend not to read those

threads..(okay, not good)

But PANDAS is the strep infection, right? I looked it up on Wiki..which is why

you suggest no stuff with 'strep' lines in it? (Sorry to sound like a dope on

the subject, I just haven't been paying attention...and I'm sorry if you feel

like a broken record! ha! lol)

Help me understand it. How to treat it. etc.

laura

>

> Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

temps. To make a long story short (ha, which is virtually impossible for me to

do) -- we put a patch of iodine on his back (between his shoulder blades), and

within 20 min, his fever reduced to around 99-100 degrees. He still has a low

grade fever (which is fine)

>

> We haven't used motrin or tylenol, and we managed to keep him hydrated. He

acts 'normal' during the day, and he usually gets the high fever at night.

>

> Today he has 'post nasal drip' (no green anything) and has a productive

cough...

>

> Here's the kicker...no jargon. Completely with it, and super calm and

intelligent thoughts, sentences, and thought processes -- he's so with it, and

so put together (even for typical kids - and I would go as far to say 'better'

than a typical child)--but he sounds like crap. The only other 'annoying' thing

is - he is consistently wetting the bed (which is just a laundry issue.) I have

upped his supps, but it's still happening. (normally, this goes away when these

are upped)

>

> (and yes, I'm now juicing for him all day because that is what he is asking

for. Ate 3 eggs this morning, and wanted more. But this is all he will eat. He

doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

>

> thoughts?

>

> laura

>

> --

> Toni

>

> ------

> Mind like a steel trap...

> Rusty and illegal in 37 states.

>

February 19, 2011

He could be viral : (

You'll whoop it .

-Tammy

To: mb12 valtrex Sent: Sat, February 19, 2011 11:30:15 AMSubject: Iodine as a fever reducer

Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+ temps. To make a long story short (ha, which is virtually impossible for me to do) -- we put a patch of iodine on his back (between his shoulder blades), and within 20 min, his fever reduced to around 99-100 degrees. He still has a low grade fever (which is fine)We haven't used motrin or tylenol, and we managed to keep him hydrated. He acts 'normal' during the day, and he usually gets the high fever at night. Today he has 'post nasal drip' (no green anything) and has a productive cough...Here's the kicker...no jargon. Completely with it, and super calm and intelligent thoughts, sentences, and thought processes -- he's so with it, and so put together (even for typical kids - and I would go as far to say 'better' than a typical child)--but he sounds like crap. The only other 'annoying' thing is - he is consistently wetting the bed (which is just a laundry

issue.) I have upped his supps, but it's still happening. (normally, this goes away when these are upped)(and yes, I'm now juicing for him all day because that is what he is asking for. Ate 3 eggs this morning, and wanted more. But this is all he will eat. He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.) thoughts? laura

February 19, 2011

It's crazy what we have turned ourselves into. Unless it costs a hundred bucks and has to be rx'd we simply can't believe it works.

God put everything we need right here on this planet. Doctors and Big Pharma want us to forget this. You can't put a patent on ginger or epsom or iodine. No doc visit for an rx, no money for big pharma. We are well-trained consumers..

-Tammy

To: mb12 valtrex Sent: Sat, February 19, 2011 12:54:48 PMSubject: Re: Iodine as a fever reducer

I agree. My husband was caught off guard with the fever (as it was high) -- and went into panic mode, thank goodness, I kept a clear head. Jimmy asked for a bath because he was hot. I have always trusted his 'instinct' -- and we did that too. I had thrown out our tylenol, but I did have motrin (dye free) on hand. So, we have putting this patch on him for two days - how long should I continue (in your opinion?)I have done a patch test on myself, it's completely gone within 3 hours, with Jimmy, his is very very 'light' but it's still there after 24 hours. I thought that the skin vs drops would be safer, I guess? I don't know, I am very new to the iodine stuff...could you post some good places to go to read? or a book?Thanks for the constant on the thread, I would have NEVER thought of iodine as a solution to a high fever -- and during the panic, I remembered and -- I thought "IODINE!" My husband, couldn't believe it, (he said it

was the bath) but the second night, no bath, just iodine, same results. He's a believer....laura > > > > >> > >> > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+> > > temps. To make a long story short (ha, which is virtually impossible for me> > > to do) -- we put a patch of iodine on his back (between his shoulder> > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He> > > still has a low grade fever (which is fine)> >

>> > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He> > > acts 'normal' during the day, and he usually gets the high fever at night.> > >> > > Today he has 'post nasal drip' (no green anything) and has a productive> > > cough...> > >> > > Here's the kicker...no jargon. Completely with it, and super calm and> > > intelligent thoughts, sentences, and thought processes -- he's so with it,> > > and so put together (even for typical kids - and I would go as far to say> > > 'better' than a typical child)--but he sounds like crap. The only other> > > 'annoying' thing is - he is consistently wetting the bed (which is just a> > > laundry issue.) I have upped his supps, but it's still happening. (normally,> > > this goes away when these are upped)> >

>> > > (and yes, I'm now juicing for him all day because that is what he is asking> > > for. Ate 3 eggs this morning, and wanted more. But this is all he will eat.> > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)> > >> > > thoughts?> > >> > > laura >

February 19, 2011

just like you would strep, I would go in for a strep test for starters, you want more then a rapid you want a culture to! so antibiotics

From: laurargoddin

Sent: Saturday, February 19, 2011 1:51 PM

To: mb12 valtrex

Subject: Re: Iodine as a fever reducer

You know, I never thought my kid was a PANDAS one..so I tend not to read those threads..(okay, not good) But PANDAS is the strep infection, right? I looked it up on Wiki..which is why you suggest no stuff with 'strep' lines in it? (Sorry to sound like a dope on the subject, I just haven't been paying attention...and I'm sorry if you feel like a broken record! ha! lol) Help me understand it. How to treat it. etc. laura > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+ temps. To make a long story short (ha, which is virtually impossible for me to do) -- we put a patch of iodine on his back (between his shoulder blades), and within 20 min, his fever reduced to around 99-100 degrees. He still has a low grade fever (which is fine)> > We haven't used motrin or tylenol, and we managed to keep him hydrated. He acts 'normal' during the day, and he usually gets the high fever at night. > > Today he has 'post nasal drip' (no green anything) and has a productive cough...> > Here's the kicker...no jargon. Completely with it, and super calm and intelligent thoughts, sentences, and thought processes -- he's so with it, and so put together (even for typical kids - and I would go as far to say 'better' than a typical child)--but he sounds like crap. The only other 'annoying' thing is - he is consistently wetting the bed (which is just a laundry issue.) I have upped his supps, but it's still happening. (normally, this goes away when these are upped)> > (and yes, I'm now juicing for him all day because that is what he is asking for. Ate 3 eggs this morning, and wanted more. But this is all he will eat. He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.) > > thoughts? > > laura > > > > > > > -- > Toni> > ------> Mind like a steel trap...> Rusty and illegal in 37 states.>

February 19, 2011

,

Can I try and tie these things together? You may not know this, but iodine is

another one of the ions that moves across the cell membrane using a

sulfate/oxalate exchanger.

This class of transporters give signals that regulate the cystic fibrosis

transporter. This CFTR transporter regulates fluid secretion in the gut and in

the mucus membranes (and pretty much every secretory organ including the

kidneys).

So unexpectedly high or low levels of sulfate, iodine or oxalate may change the

regulation of the cystic fibrosis transporter, but indirectly. When the cystic

fibrosis transporter function is entirely lost (as in the disease by the same

name), the lungs have very gunky, globby mucus because the mucus is low in

fluid, and that makes it more easily infected.

In this area, an avalanche of brand new basic science research in the last three

years has completely changed how scientists understand the regulation of fluid

and pH,and how cells of the gut and lungs protect themselves from infection. The

DAN! doctors don't know this new material yet, but they will soon, hopefully!

So, , the way these transporters work, it makes sense why adding in higher

levels of iodine might cause nasal drip, because it might change how much fluid

is crossing at the cystic fibrosis transporter.

The shared use of the same ion transporter may be telling us that high oxalate

diets would alter the absorption of iodine. It is all an issue of quantity on

each side of the cell membrane, and how things are regulated together.

People with cystic fibrosis are also very prone to infection because the missing

CFTR transporter cuts off the transport of thiocyanate and glutathione into the

mucus layer. Thiocyanate is being secreted there because it is quickly

converted right outside the cell into an antimicrobial, which is the second

reason those with CF get terrible lung infections and have bad guts, because

their secretion of thiocyanate is impaired.

What does this have to do with autism?

Dr. Rosemary Waring about twelve years ago found that the thiocyanate was also

extremely low in autism in urine. This suggests that abnormal function of the

sulfate/oxalate exchanger may be creating the perfect breeding ground for

dysbiosis that would only temporarily be helped by antibiotics or by other

antimicrobials because the drugs can kill the bugs, but cannot solve the problem

that got the bugs disordered in the first place.

This is the area of science that our project at ARI thinks explains why people

reducing oxalate in the diet see the amazing improvements in dysbiosis and why

many can finally get off the " anti-fungal parade " .

Anyway, , because these ions share transport, this is why something being

physiologically low (like sulfate or iodine) while something else is

physiologically higher than expected (like oxalate) would change the regulation

of fluid in the gut, the kidneys and the lungs.

But lets talk about the bedwetting. When the body is detoxifying oxalate, some

boys will have accidents again at night until the dump is over. We've found

that after the body detoxifies from stored oxalate over time, it is very common

for those who weren't potty trained before to become potty trained. We've even

seen older children develop urinary control including stopping bedwetting.

What about the fever? We sometimes see very high fevers accompanying dumping on

our listserve. We don't yet understand WHY this happens, but we also often have

parents saying their kids seem better while it is going on. Nighttime fevers

can be a sign of a dysregulation that DAN! doctor and thiamine expert, Derrick

Lonsdale, has reported happening in children that is treated with thiamine. (see

below) Thiamine deficiency increases the body making its own oxalate because of

impairing the mitochondrial enzyme, alpha ketoglutarate:glyoxylate carboligase.

You might find taking thiamine would help the fever. I hadn't thought about

this until now!

The body has a " set point " that measures blood oxalate levels (not urinary

levels which might not " match " ). When oxalate in blood gets too high, if things

are working right, it causes the body to turn on oxalate protective mechanisms

which are what may induce a dump. You don't have to be low oxalate for that to

happen, because the " switch " doesn't care WHERE the oxalate came from.

When you are eating high oxalate, the oxalate you are dumping may have come

recently from your diet. When your diet is low in oxalate, the increases of

blood oxalate only happen when the cells of the body start to clear oxalate,

releasing oxalate to the blood for disposal.

Sometimes, these levels of freed oxalate can be extraordinarily high, and until

the oxalate clears during the dump, there are symptoms it brings on, but as soon

as it is cleared, if that was the only source of oxalate, then you see the

improvements.

I hope this explains why these things might happen together. For more info, or

just to talk about these issues with experienced moms and dads who have seen the

same sorts of things in their children, join the support group

(Trying_Low_Oxalates ) that is linked to our website at

lowoxalate.info. It now has more than 3500 members.

lowoxalate.info

Head of the Autism Oxalate Project at ARI

PS. Years ago, a child in our neighborhood had very high night fevers and

slowly started to go blind. She was put in the hospital, but I sent her doctors

there papers talking about the relationship of thiamine deficiency to this sort

of blindness that she described as a big black hole in her central vision that

got bigger and bigger until her vision was gone. The doctors gave her IV

thiamine in the hospital, but it didn't change things. I thought it might not

because there were genetic reasons in her family that might come from a thiamine

transport defect. When she got home, her dad gave her TTFD, and her blindness

went away and fevers stopped. TTFD is a form of thiamine that crosses the cell

membrane even when there is a thiamine transport problem, but it also crosses

the blood brain barrier in a way that other forms of thiamine cannot. At any

rate, it solved the problem quickly. She is now in high school and a very

talented musician and actress!

Dev Pharmacol Ther. 1980;1(4):254-64.

Recurrent febrile lymphadenopathy treated with large doses of vitamin B1: report

of two cases.

Lonsdale D.

Abstract

The 2 children whose cases are reported here both had recurrent episodes of

fever and cervical lymphadenopathy. The conventional approach had been

unsuccessful in identifying the cause or therapy. In neither case was there an

infectious agent demonstrated, and biopsy of a pathologically enlarged lymph

gland revealed only reactive hyperplasia in each case. Abnormal metabolism was

revealed in the first patient by detecting a substance in urine which is

reported to be diagnostic for a form of subacute necrotizing

encephalomyelopathy. In the second case, red cell transketolase indicated

thiamine pyrophosphate deficiency. Both children had elevated concentrations of

folate and B12 in serum. Neither of the 2 patients had further episodes when

given a clinical trial with large doses of thiamine hydrochloride. Recurrent

episodes of febrile lymphadenopathy are extemely frequent in children and

spontaneous resolution occurs, while in others there is either proven or assumed

infection. Although final proof of therapeutic efficacy is lacking, the rapid

improvement and maintenance of health in both children was striking after

conventional therapy had failed.

PMID: 7438971

> > On Sat, Feb 19, 2011 at 11:30 AM, laurargoddin <laurargoddin@>wrote:

> >

> > >

> > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > temps. To make a long story short (ha, which is virtually impossible for

me

> > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > > still has a low grade fever (which is fine)

> > >

> > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > > acts 'normal' during the day, and he usually gets the high fever at night.

> > >

> > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > cough...

> > >

> > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > > and so put together (even for typical kids - and I would go as far to say

> > > 'better' than a typical child)--but he sounds like crap. The only other

> > > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > this goes away when these are upped)

> > >

> > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

eat.

> > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > >

> > > thoughts?

> > >

> > > laura

>

February 19, 2011

, is on our list serve... she joined a few weeks ago, and has only made a couple posts. I tried to suggest the fever-oxalate connection in private email.I did NOT know iodine shared the CFTR transporter. Thanks for that!

,

Can I try and tie these things together? You may not know this, but iodine is another one of the ions that moves across the cell membrane using a sulfate/oxalate exchanger.

This class of transporters give signals that regulate the cystic fibrosis transporter. This CFTR transporter regulates fluid secretion in the gut and in the mucus membranes (and pretty much every secretory organ including the kidneys).

So unexpectedly high or low levels of sulfate, iodine or oxalate may change the regulation of the cystic fibrosis transporter, but indirectly. When the cystic fibrosis transporter function is entirely lost (as in the disease by the same name), the lungs have very gunky, globby mucus because the mucus is low in fluid, and that makes it more easily infected.

In this area, an avalanche of brand new basic science research in the last three years has completely changed how scientists understand the regulation of fluid and pH,and how cells of the gut and lungs protect themselves from infection. The DAN! doctors don't know this new material yet, but they will soon, hopefully!

So, , the way these transporters work, it makes sense why adding in higher levels of iodine might cause nasal drip, because it might change how much fluid is crossing at the cystic fibrosis transporter.

The shared use of the same ion transporter may be telling us that high oxalate diets would alter the absorption of iodine. It is all an issue of quantity on each side of the cell membrane, and how things are regulated together.

People with cystic fibrosis are also very prone to infection because the missing CFTR transporter cuts off the transport of thiocyanate and glutathione into the mucus layer. Thiocyanate is being secreted there because it is quickly converted right outside the cell into an antimicrobial, which is the second reason those with CF get terrible lung infections and have bad guts, because their secretion of thiocyanate is impaired.

What does this have to do with autism?

Dr. Rosemary Waring about twelve years ago found that the thiocyanate was also extremely low in autism in urine. This suggests that abnormal function of the sulfate/oxalate exchanger may be creating the perfect breeding ground for dysbiosis that would only temporarily be helped by antibiotics or by other antimicrobials because the drugs can kill the bugs, but cannot solve the problem that got the bugs disordered in the first place.

This is the area of science that our project at ARI thinks explains why people reducing oxalate in the diet see the amazing improvements in dysbiosis and why many can finally get off the " anti-fungal parade " .

Anyway, , because these ions share transport, this is why something being physiologically low (like sulfate or iodine) while something else is physiologically higher than expected (like oxalate) would change the regulation of fluid in the gut, the kidneys and the lungs.

But lets talk about the bedwetting. When the body is detoxifying oxalate, some boys will have accidents again at night until the dump is over. We've found that after the body detoxifies from stored oxalate over time, it is very common for those who weren't potty trained before to become potty trained. We've even seen older children develop urinary control including stopping bedwetting.

What about the fever? We sometimes see very high fevers accompanying dumping on our listserve. We don't yet understand WHY this happens, but we also often have parents saying their kids seem better while it is going on. Nighttime fevers can be a sign of a dysregulation that DAN! doctor and thiamine expert, Derrick Lonsdale, has reported happening in children that is treated with thiamine. (see below) Thiamine deficiency increases the body making its own oxalate because of impairing the mitochondrial enzyme, alpha ketoglutarate:glyoxylate carboligase.

You might find taking thiamine would help the fever. I hadn't thought about this until now!

The body has a " set point " that measures blood oxalate levels (not urinary levels which might not " match " ). When oxalate in blood gets too high, if things are working right, it causes the body to turn on oxalate protective mechanisms which are what may induce a dump. You don't have to be low oxalate for that to happen, because the " switch " doesn't care WHERE the oxalate came from.

When you are eating high oxalate, the oxalate you are dumping may have come recently from your diet. When your diet is low in oxalate, the increases of blood oxalate only happen when the cells of the body start to clear oxalate, releasing oxalate to the blood for disposal.

Sometimes, these levels of freed oxalate can be extraordinarily high, and until the oxalate clears during the dump, there are symptoms it brings on, but as soon as it is cleared, if that was the only source of oxalate, then you see the improvements.

I hope this explains why these things might happen together. For more info, or just to talk about these issues with experienced moms and dads who have seen the same sorts of things in their children, join the support group (Trying_Low_Oxalates ) that is linked to our website at lowoxalate.info. It now has more than 3500 members.

lowoxalate.info

Head of the Autism Oxalate Project at ARI

PS. Years ago, a child in our neighborhood had very high night fevers and slowly started to go blind. She was put in the hospital, but I sent her doctors there papers talking about the relationship of thiamine deficiency to this sort of blindness that she described as a big black hole in her central vision that got bigger and bigger until her vision was gone. The doctors gave her IV thiamine in the hospital, but it didn't change things. I thought it might not because there were genetic reasons in her family that might come from a thiamine transport defect. When she got home, her dad gave her TTFD, and her blindness went away and fevers stopped. TTFD is a form of thiamine that crosses the cell membrane even when there is a thiamine transport problem, but it also crosses the blood brain barrier in a way that other forms of thiamine cannot. At any rate, it solved the problem quickly. She is now in high school and a very talented musician and actress!

Dev Pharmacol Ther. 1980;1(4):254-64.

Recurrent febrile lymphadenopathy treated with large doses of vitamin B1: report of two cases.

Lonsdale D.

Abstract

The 2 children whose cases are reported here both had recurrent episodes of fever and cervical lymphadenopathy. The conventional approach had been unsuccessful in identifying the cause or therapy. In neither case was there an infectious agent demonstrated, and biopsy of a pathologically enlarged lymph gland revealed only reactive hyperplasia in each case. Abnormal metabolism was revealed in the first patient by detecting a substance in urine which is reported to be diagnostic for a form of subacute necrotizing encephalomyelopathy. In the second case, red cell transketolase indicated thiamine pyrophosphate deficiency. Both children had elevated concentrations of folate and B12 in serum. Neither of the 2 patients had further episodes when given a clinical trial with large doses of thiamine hydrochloride. Recurrent episodes of febrile lymphadenopathy are extemely frequent in children and spontaneous resolution occurs, while in others there is either proven or assumed infection. Although final proof of therapeutic efficacy is lacking, the rapid improvement and maintenance of health in both children was striking after conventional therapy had failed.

PMID: 7438971

> > On Sat, Feb 19, 2011 at 11:30 AM, laurargoddin <laurargoddin@>wrote:

> >

> > >

> > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > temps. To make a long story short (ha, which is virtually impossible for me

> > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > > still has a low grade fever (which is fine)

> > >

> > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > > acts 'normal' during the day, and he usually gets the high fever at night.

> > >

> > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > cough...

> > >

> > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > > and so put together (even for typical kids - and I would go as far to say

> > > 'better' than a typical child)--but he sounds like crap. The only other

> > > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > > laundry issue.) I have upped his supps, but it's still happening. (normally,

> > > this goes away when these are upped)

> > >

> > > (and yes, I'm now juicing for him all day because that is what he is asking

> > > for. Ate 3 eggs this morning, and wanted more. But this is all he will eat.

> > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > >

> > > thoughts?

> > >

> > > laura

>

-- Toni------Mind like a steel trap...Rusty and illegal in 37 states.

February 19, 2011

Amen sista Tammy!!!

> > >

> > > >

> > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > > temps. To make a long story short (ha, which is virtually impossible for

> me

> > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > blades), and within 20 min, his fever reduced to around 99-100 degrees.

He

> > > > still has a low grade fever (which is fine)

> > > >

> > > > We haven't used motrin or tylenol, and we managed to keep him hydrated.

He

> > > > acts 'normal' during the day, and he usually gets the high fever at

night.

> > > >

> > > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > > cough...

> > > >

> > > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > > intelligent thoughts, sentences, and thought processes -- he's so with

it,

> > > > and so put together (even for typical kids - and I would go as far to

say

> > > > 'better' than a typical child)--but he sounds like crap. The only other

> > > > 'annoying' thing is - he is consistently wetting the bed (which is just

a

> > > > laundry issue.) I have upped his supps, but it's still happening.

> >(normally,

> > > > this goes away when these are upped)

> > > >

> > > > (and yes, I'm now juicing for him all day because that is what he is

> asking

> > > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

> eat.

> > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > > >

> > > > thoughts?

> > > >

> > > > laura

> >

>

February 19, 2011

Amazing, Amazing post! You have a great way of explaining things, .

-Tammy

To: mb12 valtrex Sent: Sat, February 19, 2011 3:39:04 PMSubject: Re: Iodine as a fever reducer

,Can I try and tie these things together? You may not know this, but iodine is another one of the ions that moves across the cell membrane using a sulfate/oxalate exchanger.This class of transporters give signals that regulate the cystic fibrosis transporter. This CFTR transporter regulates fluid secretion in the gut and in the mucus membranes (and pretty much every secretory organ including the kidneys). So unexpectedly high or low levels of sulfate, iodine or oxalate may change the regulation of the cystic fibrosis transporter, but indirectly. When the cystic fibrosis transporter function is entirely lost (as in the disease by the same name), the lungs have very gunky, globby mucus because the mucus is low in fluid, and that makes it more easily infected. In this area, an avalanche of brand new basic science research in the last three years has completely changed how scientists understand the regulation of fluid

and pH,and how cells of the gut and lungs protect themselves from infection. The DAN! doctors don't know this new material yet, but they will soon, hopefully! So, , the way these transporters work, it makes sense why adding in higher levels of iodine might cause nasal drip, because it might change how much fluid is crossing at the cystic fibrosis transporter.The shared use of the same ion transporter may be telling us that high oxalate diets would alter the absorption of iodine. It is all an issue of quantity on each side of the cell membrane, and how things are regulated together.People with cystic fibrosis are also very prone to infection because the missing CFTR transporter cuts off the transport of thiocyanate and glutathione into the mucus layer. Thiocyanate is being secreted there because it is quickly converted right outside the cell into an antimicrobial, which is the second reason those with CF get terrible lung

infections and have bad guts, because their secretion of thiocyanate is impaired.What does this have to do with autism?Dr. Rosemary Waring about twelve years ago found that the thiocyanate was also extremely low in autism in urine. This suggests that abnormal function of the sulfate/oxalate exchanger may be creating the perfect breeding ground for dysbiosis that would only temporarily be helped by antibiotics or by other antimicrobials because the drugs can kill the bugs, but cannot solve the problem that got the bugs disordered in the first place. This is the area of science that our project at ARI thinks explains why people reducing oxalate in the diet see the amazing improvements in dysbiosis and why many can finally get off the "anti-fungal parade". Anyway, , because these ions share transport, this is why something being physiologically low (like sulfate or iodine) while something else is physiologically higher

than expected (like oxalate) would change the regulation of fluid in the gut, the kidneys and the lungs.But lets talk about the bedwetting. When the body is detoxifying oxalate, some boys will have accidents again at night until the dump is over. We've found that after the body detoxifies from stored oxalate over time, it is very common for those who weren't potty trained before to become potty trained. We've even seen older children develop urinary control including stopping bedwetting.What about the fever? We sometimes see very high fevers accompanying dumping on our listserve. We don't yet understand WHY this happens, but we also often have parents saying their kids seem better while it is going on. Nighttime fevers can be a sign of a dysregulation that DAN! doctor and thiamine expert, Derrick Lonsdale, has reported happening in children that is treated with thiamine. (see below) Thiamine deficiency increases the body making its own

oxalate because of impairing the mitochondrial enzyme, alpha ketoglutarate:glyoxylate carboligase. You might find taking thiamine would help the fever. I hadn't thought about this until now!The body has a "set point" that measures blood oxalate levels (not urinary levels which might not "match"). When oxalate in blood gets too high, if things are working right, it causes the body to turn on oxalate protective mechanisms which are what may induce a dump. You don't have to be low oxalate for that to happen, because the "switch" doesn't care WHERE the oxalate came from. When you are eating high oxalate, the oxalate you are dumping may have come recently from your diet. When your diet is low in oxalate, the increases of blood oxalate only happen when the cells of the body start to clear oxalate, releasing oxalate to the blood for disposal.Sometimes, these levels of freed oxalate can be extraordinarily high, and until the

oxalate clears during the dump, there are symptoms it brings on, but as soon as it is cleared, if that was the only source of oxalate, then you see the improvements.I hope this explains why these things might happen together. For more info, or just to talk about these issues with experienced moms and dads who have seen the same sorts of things in their children, join the support group (Trying_Low_Oxalates ) that is linked to our website at lowoxalate.info. It now has more than 3500 members.lowoxalate.infoHead of the Autism Oxalate Project at ARIPS. Years ago, a child in our neighborhood had very high night fevers and slowly started to go blind. She was put in the hospital, but I sent her doctors there papers

talking about the relationship of thiamine deficiency to this sort of blindness that she described as a big black hole in her central vision that got bigger and bigger until her vision was gone. The doctors gave her IV thiamine in the hospital, but it didn't change things. I thought it might not because there were genetic reasons in her family that might come from a thiamine transport defect. When she got home, her dad gave her TTFD, and her blindness went away and fevers stopped. TTFD is a form of thiamine that crosses the cell membrane even when there is a thiamine transport problem, but it also crosses the blood brain barrier in a way that other forms of thiamine cannot. At any rate, it solved the problem quickly. She is now in high school and a very talented musician and actress!Dev Pharmacol Ther. 1980;1(4):254-64.Recurrent febrile lymphadenopathy treated with large doses of vitamin B1: report of two cases.Lonsdale

D.AbstractThe 2 children whose cases are reported here both had recurrent episodes of fever and cervical lymphadenopathy. The conventional approach had been unsuccessful in identifying the cause or therapy. In neither case was there an infectious agent demonstrated, and biopsy of a pathologically enlarged lymph gland revealed only reactive hyperplasia in each case. Abnormal metabolism was revealed in the first patient by detecting a substance in urine which is reported to be diagnostic for a form of subacute necrotizing encephalomyelopathy. In the second case, red cell transketolase indicated thiamine pyrophosphate deficiency. Both children had elevated concentrations of folate and B12 in serum. Neither of the 2 patients had further episodes when given a clinical trial with large doses of thiamine hydrochloride. Recurrent episodes of febrile lymphadenopathy are extemely frequent in children and spontaneous resolution occurs, while in others

there is either proven or assumed infection. Although final proof of therapeutic efficacy is lacking, the rapid improvement and maintenance of health in both children was striking after conventional therapy had failed.PMID: 7438971> > On Sat, Feb 19, 2011 at 11:30 AM, laurargoddin <laurargoddin@>wrote:> > > > >> > >> > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+> > > temps. To make a long story short (ha, which is virtually impossible for me> > > to do) -- we put a patch of iodine on his back (between his shoulder> > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He> > > still has a low grade fever (which is fine)> > >> > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He> > > acts 'normal' during the day,

and he usually gets the high fever at night.> > >> > > Today he has 'post nasal drip' (no green anything) and has a productive> > > cough...> > >> > > Here's the kicker...no jargon. Completely with it, and super calm and> > > intelligent thoughts, sentences, and thought processes -- he's so with it,> > > and so put together (even for typical kids - and I would go as far to say> > > 'better' than a typical child)--but he sounds like crap. The only other> > > 'annoying' thing is - he is consistently wetting the bed (which is just a> > > laundry issue.) I have upped his supps, but it's still happening. (normally,> > > this goes away when these are upped)> > >> > > (and yes, I'm now juicing for him all day because that is what he is asking> > > for. Ate 3 eggs this morning, and

wanted more. But this is all he will eat.> > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)> > >> > > thoughts?> > >> > > laura >

February 19, 2011

,

This is excellent information. THANK YOU! Toni (who convinced me that Jimmy

needed a low ox diet) said that the fevers could be from oxalates.

Interestingly enough, I had come across Beri-Beri about a month ago, and thought

" gee, Jimmy seems to have some of these symptoms. " and then I was like " I'm

tired, and I must be thinking it all sounds like my child! " HA!

During his high fever episode, he asked for garlic to be put in his juicer juice

that I make him (low ox!). I was like 'this tastes a little gross' - but he

sucked it back and was asking for more in the morning. Garlic is high in B1 --

the TTFD one. I have always (always) trusted Jimmy to tell me what he needs, I

tend not to question it too much. That night was totally into 'smelling'

things. He smelled the motrin and refused it. He was playing with my

ingredients when he saw the garlic and wouldn't let it go until I put it in the

drink.

So my questions to you are: - when he has a high fever, Iodine can be used, or

should I try something else? I am/was so excited that I got to stay away from

drugs, as I really try to use them as a last resort. (I'm not opposed, it's

just not my first choice. I tend to like the natural route.)

I didn't put epsom salts in his bath that night, should I be doing that when he

asks for a bath to help the transport/sulfation?

And I juice for him twice daily (for the past couple that is all he will consume

along with eggs. Funny, I make his eggs with garlic and onions.) But I do use

some high oxalate ingredients but when I do, I give him calcium citrate 20 min

prior. Should I still do this, or should I just focus on giving him the low

oxalate equivalent? (I do juice with beets, and I know they are super high ox,

should I stop this practice till the dump is over? )

His mental clarity is amazing. He is so together, and thoughtful, and he is

wicked smart for a 4 year old...and his speech, he has struggled with his

expressive speech for a year and half, but is doing great, and the past couple

of days, he's better than his peers. So we are excited, but waiting to see if

it will 'stick.' So close...

, your listserve is amazing. I have learned a lot. (I tend to read more

than post over there) I have so many questions, and probably go over there to

post more. Your insight would be great. I know we are so close to our recovery

(and most would say we are recovered)...But I feel we aren't done.

laura

> > >

> > > >

> > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > > temps. To make a long story short (ha, which is virtually impossible for

me

> > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > blades), and within 20 min, his fever reduced to around 99-100 degrees.

He

> > > > still has a low grade fever (which is fine)

> > > >

> > > > We haven't used motrin or tylenol, and we managed to keep him hydrated.

He

> > > > acts 'normal' during the day, and he usually gets the high fever at

night.

> > > >

> > > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > > cough...

> > > >

> > > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > > intelligent thoughts, sentences, and thought processes -- he's so with

it,

> > > > and so put together (even for typical kids - and I would go as far to

say

> > > > 'better' than a typical child)--but he sounds like crap. The only other

> > > > 'annoying' thing is - he is consistently wetting the bed (which is just

a

> > > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > > this goes away when these are upped)

> > > >

> > > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

eat.

> > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > > >

> > > > thoughts?

> > > >

> > > > laura

> >

>

February 19, 2011

,

I just had a facebook conversation with another mom whose son is I think on his

fourth or fifth day of high fever, and now he is sleeping 16 hours a day. This

pattern is so much like what I saw in my daughter when she was in high school

and had health crashes. After having a fever, twice, she got to where she was

sleeping 16 hours a day, and couldn't get to school for more than a week. No

one could figure out why this onset of sleep happened to her.

All her life, she would have episodes of what we thought was flu, but the rest

of the family wouldn't get sick. It would last a week, and she would run fever

and miss school, and often at the end, her temperature would be subnormal. One

time it went down to 94 degrees.

We got to the doctor about four days into one of these times, and he did a CBC

and it came back perfectly normal, evidence that she WASN'T sick, or at least

her immune system didn't think it was!

After the last episode like this, we had her tested and she was extremely low in

vitamin D, but this vitamin is MADE in the mitochondrion, so it may be that

those with mitochondrial issues, even if they are brought on by oxalate, get low

in vitamin D for that reason.

At any rate, now looking at your story, that you were a few days into the low

oxalate diet and then gave your son beets, your timing was right at the expected

time of the first dump. However, once someone lowers oxalate, they tend to dump

more severely than they would have otherwise to an oxalate infraction. What a

set-up! (unfotunately! I'm sorry you were not warned....)

My daughter, when she was in tenth grade humored me by trying low oxalate for

about a month to see if it would help her health. It seemed a good thing, but

we had a birthday celebration and she had a tiny piece of Pamela's chocolate

cake....extraordinarily dense in oxalate, but something we were accustomed to

use to celebrate her birthday for every birthday since she was five without any

noticeable effect.

Her hands in a few minutes turned bright red, and soon they were oozing white

crystals....something we had heard about on our listserve happening in people

with fibro when they dump. (My daughter was later diagnosed with fibro.) We

have pictures listmates have put up in the photo section showing this odd

phenomenon.

My daughter's immediate reaction to this very odd thing happening to her hands

was to tell me that my silly diet had ruined her for her favorite food, and that

she would no longer do the diet. That was the end of her being low oxalate.

Her health CRASHED in the next few years with severe problems with fibromyalgia.

Fevers are caused by IL-1 which is also called pyrogen because of the way it

induces fevers. Apparently having " crystalline substances " showing up in the

cytosol of your cells induces the production of IL-1 which could make your body

react like it was sick when it isn't!

So fevers involved with oxalate dumping may have NOTHING to do with being sick.

We have seen many people get high fevers with dumping.

IL-1, also, if it keeps being produced, may make someone sleep too much. (see

below)

We parents MUST tell our stories. There is truth and hope and discovery in the

telling of them.

Nat Rev Neurosci. 2009 Mar;10(3):199-210. Epub 2009 Feb 11.

How (and why) the immune system makes us sleep.

Imeri L, Opp MR.

Department of Human Physiology and Giuseppe Moruzzi Centre for Experimental

Sleep Research, University of Milan Medical School, 20133 Milan, Italy.

Abstract

Good sleep is necessary for physical and mental health. For example, sleep loss

impairs immune function, and sleep is altered during infection. Immune

signalling molecules are present in the healthy brain, where they interact with

neurochemical systems to contribute to the regulation of normal sleep. Animal

studies have shown that interactions between immune signalling molecules (such

as the cytokine interleukin 1) and brain neurochemical systems (such as the

serotonin system) are amplified during infection, indicating that these

interactions might underlie the changes in sleep that occur during infection.

Why should the immune system cause us to sleep differently when we are sick? We

propose that the alterations in sleep architecture during infection are

exquisitely tailored to support the generation of fever, which in turn imparts

survival value.

PMID: 19209176

J Endourol. 2007 Dec;21(12):1565-70.

Association of interleukin-1beta gene and receptor antagonist polymorphisms with

calcium oxalate urolithiasis.

Mittal RD, Bid HK, Manchanda PK, Kapoor R.

Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical

Sciences, Lucknow, Uttar Pradesh, India. ramamittal@...

Abstract

BACKGROUND AND PURPOSE: Genetic polymorphisms of the interleukin-1beta

(IL-1beta) promoter region (-511) and exon 5 +3954 and a variable number of

tandem repeats in the IL receptor antagonist (IL-1RA) gene have been proposed as

markers for calcium oxalate urolithiasis. Because the prevalence of these

polymorphisms could be influenced by racial variation/ethnicity, we explored the

association of IL-1 gene-cluster polymorphisms with stone formation in a north

India population.

PATIENTS AND METHODS: The case-control study involved 150 stone-free control

subjects (mean age 46.5 +/- 10.5 years) and 130 patients (mean age 40.0 +/- 11.5

years) with calcium oxalate urolithiasis. Biallelic polymorphisms of two loci,

IL-1beta (-511) and IL-1beta (+3954), as well as the penta-allelic variable

number of tandem repeats of IL-1RA, were genotyped by polymerase chain

reaction-based restriction analysis. Haplotypes were constructed for the IL-1

gene cluster using SNP Analyzer software.

RESULTS: We observed a significant association between stone disease and

IL-1beta -511 and IL-1RA polymorphisms (P < 0.001 and P = 0.039, respectively),

whereas no association was observed for IL-1beta +3954 (P = 0.408). The

frequency of the TT (-511) and I/II (410/240; IL-1RA) genotypes was higher in

patients than in control subjects (50/130 v 16/150 and 55/130 v 38/150,

respectively), whereas the frequencies of the haplotypes were similar (P =

0.485). Significant linkage disequilibrium showed that three genes were strongly

linked (P < 0.0001). Patients with a combination of high IL-1beta (-511 and

+3954) and low IL-1RA genotypes were at significantly higher risk for

urolithiasis (P < 0.001; odds ratio = 5.448, 0.013, and 2.560, respectively).

CONCLUSION: Our study demonstrated a strong association of IL-1RA and

IL-1beta-511 and suggested that differences in the IL-1 gene cluster could be

linked to the risk of urolithiasis. A combination of IL-1beta and IL-1RA

associations exhibiting gene-gene interaction further substantiates the finding

of risk.

PMID: 18186699

Int J Biochem Cell Biol. 2010 Jun;42(6):792-5. Epub 2010 Jan 13.

Nlrp3: an immune sensor of cellular stress and infection.

Lamkanfi M, Kanneganti TD.

Department of Biochemistry, Ghent University, VIB, B-9000 Ghent, Belgium.

Abstract

Innate immune cells rely on pathogen recognition receptors such as the

nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family

to mount an appropriate immune response against microbial threats. The NLR

protein Nlrp3 senses microbial ligands, endogenous danger signals *******and

crystalline substances in the cytosol ********to trigger the assembly of a large

caspase-1-activating protein complex termed the Nlrp3 inflammasome.

Autoproteolytic maturation of caspase-1 zymogens in the Nlrp3 inflammasome leads

to maturation and extracellular release of the pro-inflammatory cytokines

interleukin (IL)-1beta and IL-18. Gain-of-function mutations in the NOD domain

of Nlrp3 are associated with auto-inflammatory disorders characterized by skin

rashes and prolonged episodes of fever. In addition, decreased Nlrp3 expression

was recently linked with susceptibility to Crohn's disease in humans. In this

review, we discuss recent developments on the role of the Nlrp3 inflammasome in

innate immunity, its activation mechanisms and the auto-inflammatory disorders

associated with deregulation of Nlrp3 inflammasome activity.

PMID: 20079456

> > > >

> > > > >

> > > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with

103+

> > > > > temps. To make a long story short (ha, which is virtually impossible

for me

> > > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > > blades), and within 20 min, his fever reduced to around 99-100

degrees. He

> > > > > still has a low grade fever (which is fine)

> > > > >

> > > > > We haven't used motrin or tylenol, and we managed to keep him

hydrated. He

> > > > > acts 'normal' during the day, and he usually gets the high fever at

night.

> > > > >

> > > > > Today he has 'post nasal drip' (no green anything) and has a

productive

> > > > > cough...

> > > > >

> > > > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > > > intelligent thoughts, sentences, and thought processes -- he's so with

it,

> > > > > and so put together (even for typical kids - and I would go as far to

say

> > > > > 'better' than a typical child)--but he sounds like crap. The only

other

> > > > > 'annoying' thing is - he is consistently wetting the bed (which is

just a

> > > > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > > > this goes away when these are upped)

> > > > >

> > > > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

eat.

> > > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > > > >

> > > > > thoughts?

> > > > >

> > > > > laura

> > >

> >

>

February 19, 2011

,

We know that Jimmy had low Vitamin D, as he showed signs of knock knees. I

supplement vitamin D, and he gets the sun about 20 min a day (or more).

So what do I do? He complained of being sleepy today, but didn't take a nap.

Do I remain low ox for him - even when juicing, and forget the calcium? Give

him more calcium?

I have so many questions.. I'm going to the list serve...gah!

laura

> > > > >

> > > > > >

> > > > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with

103+

> > > > > > temps. To make a long story short (ha, which is virtually impossible

for me

> > > > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > > > blades), and within 20 min, his fever reduced to around 99-100

degrees. He

> > > > > > still has a low grade fever (which is fine)

> > > > > >

> > > > > > We haven't used motrin or tylenol, and we managed to keep him

hydrated. He

> > > > > > acts 'normal' during the day, and he usually gets the high fever at

night.

> > > > > >

> > > > > > Today he has 'post nasal drip' (no green anything) and has a

productive

> > > > > > cough...

> > > > > >

> > > > > > Here's the kicker...no jargon. Completely with it, and super calm

and

> > > > > > intelligent thoughts, sentences, and thought processes -- he's so

with it,

> > > > > > and so put together (even for typical kids - and I would go as far

to say

> > > > > > 'better' than a typical child)--but he sounds like crap. The only

other

> > > > > > 'annoying' thing is - he is consistently wetting the bed (which is

just a

> > > > > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > > > > this goes away when these are upped)

> > > > > >

> > > > > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > > > > for. Ate 3 eggs this morning, and wanted more. But this is all he

will eat.

> > > > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer

juice.)

> > > > > >

> > > > > > thoughts?

> > > > > >

> > > > > > laura

> > > >

> > >

> >

>

February 19, 2011

Wait, I don't get it. What is wrong with eating eggs? I thought they were okay?

> >

> > >

> > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > temps. To make a long story short (ha, which is virtually impossible for

me

> > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > > still has a low grade fever (which is fine)

> > >

> > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > > acts 'normal' during the day, and he usually gets the high fever at night.

> > >

> > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > cough...

> > >

> > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > > and so put together (even for typical kids - and I would go as far to say

> > > 'better' than a typical child)--but he sounds like crap. The only other

> > > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > this goes away when these are upped)

> > >

> > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

eat.

> > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > >

> > > thoughts?

> > >

> > > laura

> > >

> >

> > --

> > Toni

> >

> > ------

> > Mind like a steel trap...

> > Rusty and illegal in 37 states.

> >

>

February 20, 2011

Sara,

eggs are fine. They are high in biotin, which helps with an oxalate and

mitochondrial issues. Those on the low ox diet, tend to supplement with biotin

- megadoses. Toni is our resident oxalate go to girl.

laura

> > >

> > > >

> > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > > temps. To make a long story short (ha, which is virtually impossible for

me

> > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > blades), and within 20 min, his fever reduced to around 99-100 degrees.

He

> > > > still has a low grade fever (which is fine)

> > > >

> > > > We haven't used motrin or tylenol, and we managed to keep him hydrated.

He

> > > > acts 'normal' during the day, and he usually gets the high fever at

night.

> > > >

> > > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > > cough...

> > > >

> > > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > > intelligent thoughts, sentences, and thought processes -- he's so with

it,

> > > > and so put together (even for typical kids - and I would go as far to

say

> > > > 'better' than a typical child)--but he sounds like crap. The only other

> > > > 'annoying' thing is - he is consistently wetting the bed (which is just

a

> > > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > > this goes away when these are upped)

> > > >

> > > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

eat.

> > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > > >

> > > > thoughts?

> > > >

> > > > laura

> > > >

> > >

> > > --

> > > Toni

> > >

> > > ------

> > > Mind like a steel trap...

> > > Rusty and illegal in 37 states.

> > >

> >

>

February 20, 2011

Phew! I finally got Crosby eating scrambled eggs and was going to be so

devastated if I had to take them out.

BTW , do you have a " fast " way for adding garlic to stuff? Maybe I just

have a crappy garlic press, but I hadn't thought of adding garlic to his eggs

and it just takes sooo much time to peel a clove and then press it, only to get

like 1/8 of a tsp. out!

> > > >

> > > > >

> > > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with

103+

> > > > > temps. To make a long story short (ha, which is virtually impossible

for me

> > > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > > blades), and within 20 min, his fever reduced to around 99-100

degrees. He

> > > > > still has a low grade fever (which is fine)

> > > > >

> > > > > We haven't used motrin or tylenol, and we managed to keep him

hydrated. He

> > > > > acts 'normal' during the day, and he usually gets the high fever at

night.

> > > > >

> > > > > Today he has 'post nasal drip' (no green anything) and has a

productive

> > > > > cough...

> > > > >

> > > > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > > > intelligent thoughts, sentences, and thought processes -- he's so with

it,

> > > > > and so put together (even for typical kids - and I would go as far to

say

> > > > > 'better' than a typical child)--but he sounds like crap. The only

other

> > > > > 'annoying' thing is - he is consistently wetting the bed (which is

just a

> > > > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > > > this goes away when these are upped)

> > > > >

> > > > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > > > for. Ate 3 eggs this morning, and wanted more. But this is all he will

eat.

> > > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > > > >

> > > > > thoughts?

> > > > >

> > > > > laura

> > > > >

> > > >

> > > > --

> > > > Toni

> > > >

> > > > ------

> > > > Mind like a steel trap...

> > > > Rusty and illegal in 37 states.

> > > >

> > >

> >

>

February 20, 2011

I've purchased peeled cloves in the store. It comes in a plastic jar though. Maybe come home and wash them good, pat dry and place in a glass container.You can also buy crushed garlic in jars.And I've bought Kyolic as well, but mine can swallow pills.

Phew! I finally got Crosby eating scrambled eggs and was going to be so devastated if I had to take them out.

BTW , do you have a " fast " way for adding garlic to stuff? Maybe I just have a crappy garlic press, but I hadn't thought of adding garlic to his eggs and it just takes sooo much time to peel a clove and then press it, only to get like 1/8 of a tsp. out!

> > > >

> > > > >

> > > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > > > temps. To make a long story short (ha, which is virtually impossible for me

> > > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > > > > still has a low grade fever (which is fine)

> > > > >

> > > > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > > > > acts 'normal' during the day, and he usually gets the high fever at night.

> > > > >

> > > > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > > > cough...

> > > > >

> > > > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > > > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > > > > and so put together (even for typical kids - and I would go as far to say

> > > > > 'better' than a typical child)--but he sounds like crap. The only other

> > > > > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > > > > laundry issue.) I have upped his supps, but it's still happening. (normally,

> > > > > this goes away when these are upped)

> > > > >

> > > > > (and yes, I'm now juicing for him all day because that is what he is asking

> > > > > for. Ate 3 eggs this morning, and wanted more. But this is all he will eat.

> > > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > > > >

> > > > > thoughts?

> > > > >

> > > > > laura

> > > > >

> > > >

> > > > --

> > > > Toni

> > > >

> > > > ------

> > > > Mind like a steel trap...

> > > > Rusty and illegal in 37 states.

> > > >

> > >

> >

>

-- Toni------Mind like a steel trap...Rusty and illegal in 37 states.

February 20, 2011

Agreed. It sucks! So this is what I do...(it saves a ton of time on the flip

side)

I buy mine fresh. Peel it all, put it in a food processor. Then I use a glass

jar and put about 1/8 cup of olive oil, and all the garlic I just made. I put

in the frig. And use as needed, I go thru a lot of garlic. (and when i make

eggs, i just saute it in the olive oil, with some onions. (you can also add

onions to the mix as well...I tend to like my onions fresh though)

it's fast to do it this way, and the olive oil takes on the garlic taste, and

sometimes I will take any left over olive oil, cut up some bread into cubes

(millet/gf/cf, etc) and toss it in a container with a lid and some salt, throw

them on a cookie sheet, bake at 350 for about 8-10 min. and wha la, you've got

garlic croutons! (mine eat them like little snack crackers..)

I am gf/cf too now, and I miss some of my old favs like chicken caesar

salad...so, I improvise.

laura

I got my glass jar from the coconut oil I used (garden of eden), I washed it

out, and then reused the jar. it's got a nice wide mouth on it. I have also

used the wide mouth jelly jars as well.

> > > > >

> > > > > >

> > > > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with

103+

> > > > > > temps. To make a long story short (ha, which is virtually impossible

for me

> > > > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > > > blades), and within 20 min, his fever reduced to around 99-100

degrees. He

> > > > > > still has a low grade fever (which is fine)

> > > > > >

> > > > > > We haven't used motrin or tylenol, and we managed to keep him

hydrated. He

> > > > > > acts 'normal' during the day, and he usually gets the high fever at

night.

> > > > > >

> > > > > > Today he has 'post nasal drip' (no green anything) and has a

productive

> > > > > > cough...

> > > > > >

> > > > > > Here's the kicker...no jargon. Completely with it, and super calm

and

> > > > > > intelligent thoughts, sentences, and thought processes -- he's so

with it,

> > > > > > and so put together (even for typical kids - and I would go as far

to say

> > > > > > 'better' than a typical child)--but he sounds like crap. The only

other

> > > > > > 'annoying' thing is - he is consistently wetting the bed (which is

just a

> > > > > > laundry issue.) I have upped his supps, but it's still happening.

(normally,

> > > > > > this goes away when these are upped)

> > > > > >

> > > > > > (and yes, I'm now juicing for him all day because that is what he is

asking

> > > > > > for. Ate 3 eggs this morning, and wanted more. But this is all he

will eat.

> > > > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer

juice.)

> > > > > >

> > > > > > thoughts?

> > > > > >

> > > > > > laura

> > > > > >

> > > > >

> > > > > --

> > > > > Toni

> > > > >

> > > > > ------

> > > > > Mind like a steel trap...

> > > > > Rusty and illegal in 37 states.

> > > > >

> > > >

> > >

> >

>

February 20, 2011

I get a pretty glass souvenir jar from my Manuka honey.

Agreed. It sucks! So this is what I do...(it saves a ton of time on the flip side)

I buy mine fresh. Peel it all, put it in a food processor. Then I use a glass jar and put about 1/8 cup of olive oil, and all the garlic I just made. I put in the frig. And use as needed, I go thru a lot of garlic. (and when i make eggs, i just saute it in the olive oil, with some onions. (you can also add onions to the mix as well...I tend to like my onions fresh though)

it's fast to do it this way, and the olive oil takes on the garlic taste, and sometimes I will take any left over olive oil, cut up some bread into cubes (millet/gf/cf, etc) and toss it in a container with a lid and some salt, throw them on a cookie sheet, bake at 350 for about 8-10 min. and wha la, you've got garlic croutons! (mine eat them like little snack crackers..)

I am gf/cf too now, and I miss some of my old favs like chicken caesar salad...so, I improvise.

laura

I got my glass jar from the coconut oil I used (garden of eden), I washed it out, and then reused the jar. it's got a nice wide mouth on it. I have also used the wide mouth jelly jars as well.

> > > > >

> > > > > >

> > > > > > Just wanted to report, Jimmy has had a fever 2 nights in a row with 103+

> > > > > > temps. To make a long story short (ha, which is virtually impossible for me

> > > > > > to do) -- we put a patch of iodine on his back (between his shoulder

> > > > > > blades), and within 20 min, his fever reduced to around 99-100 degrees. He

> > > > > > still has a low grade fever (which is fine)

> > > > > >

> > > > > > We haven't used motrin or tylenol, and we managed to keep him hydrated. He

> > > > > > acts 'normal' during the day, and he usually gets the high fever at night.

> > > > > >

> > > > > > Today he has 'post nasal drip' (no green anything) and has a productive

> > > > > > cough...

> > > > > >

> > > > > > Here's the kicker...no jargon. Completely with it, and super calm and

> > > > > > intelligent thoughts, sentences, and thought processes -- he's so with it,

> > > > > > and so put together (even for typical kids - and I would go as far to say

> > > > > > 'better' than a typical child)--but he sounds like crap. The only other

> > > > > > 'annoying' thing is - he is consistently wetting the bed (which is just a

> > > > > > laundry issue.) I have upped his supps, but it's still happening. (normally,

> > > > > > this goes away when these are upped)

> > > > > >

> > > > > > (and yes, I'm now juicing for him all day because that is what he is asking

> > > > > > for. Ate 3 eggs this morning, and wanted more. But this is all he will eat.

> > > > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer juice.)

> > > > > >

> > > > > > thoughts?

> > > > > >

> > > > > > laura

> > > > > >

> > > > >

> > > > > --

> > > > > Toni

> > > > >

> > > > > ------

> > > > > Mind like a steel trap...

> > > > > Rusty and illegal in 37 states.

> > > > >

> > > >

> > >

> >

>

-- Toni------Mind like a steel trap...Rusty and illegal in 37 states.

February 20, 2011

yes...I love that stuff...so good with sleepytime tea...ahh..sleep...

> > > > > > >

> > > > > > > >

> > > > > > > > Just wanted to report, Jimmy has had a fever 2 nights in a row

> > with 103+

> > > > > > > > temps. To make a long story short (ha, which is virtually

> > impossible for me

> > > > > > > > to do) -- we put a patch of iodine on his back (between his

> > shoulder

> > > > > > > > blades), and within 20 min, his fever reduced to around 99-100

> > degrees. He

> > > > > > > > still has a low grade fever (which is fine)

> > > > > > > >

> > > > > > > > We haven't used motrin or tylenol, and we managed to keep him

> > hydrated. He

> > > > > > > > acts 'normal' during the day, and he usually gets the high

> > fever at night.

> > > > > > > >

> > > > > > > > Today he has 'post nasal drip' (no green anything) and has a

> > productive

> > > > > > > > cough...

> > > > > > > >

> > > > > > > > Here's the kicker...no jargon. Completely with it, and super

> > calm and

> > > > > > > > intelligent thoughts, sentences, and thought processes -- he's

> > so with it,

> > > > > > > > and so put together (even for typical kids - and I would go as

> > far to say

> > > > > > > > 'better' than a typical child)--but he sounds like crap. The

> > only other

> > > > > > > > 'annoying' thing is - he is consistently wetting the bed (which

> > is just a

> > > > > > > > laundry issue.) I have upped his supps, but it's still

> > happening. (normally,

> > > > > > > > this goes away when these are upped)

> > > > > > > >

> > > > > > > > (and yes, I'm now juicing for him all day because that is what

> > he is asking

> > > > > > > > for. Ate 3 eggs this morning, and wanted more. But this is all

> > he will eat.

> > > > > > > > He doesn't want crackers, or sweets, nothing. Eggs and juicer

> > juice.)

> > > > > > > >

> > > > > > > > thoughts?

> > > > > > > >

> > > > > > > > laura

> > > > > > > >

> > > > > > >

> > > > > > > --

> > > > > > > Toni

> > > > > > >

> > > > > > > ------

> > > > > > > Mind like a steel trap...

> > > > > > > Rusty and illegal in 37 states.

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

> --

> Toni

>

> ------

> Mind like a steel trap...

> Rusty and illegal in 37 states.

>

February 21, 2011

,

This post really got me thinking. Very nice explanation.

I think you tied things in my mind! Which made me have more questions.

The iodine oxalate connection. Very fascinating. Have never seen it put so

eloquently. Or understandable! I had to think and read more before i could ask

more.

If i understand correctly a low oxalate diet allows what iodine the body has

work more efficiently. Thats the simple version. Similiar to how i have learned

about how goitrogens effect iodine availablity.

The foods seems to cross in some aspects, with some known goitrogen foods on

low oxalate lists. But some considered low goitrogen on the high oxalate so dont

know how it compares that much. I dont even pretend to know all the oxalate

foods, or goitrogens (yet), i have to learn more! I have learned alot since your

post tho cause it sparked so many connections and questions.

It's like i can now see the process of iodine, which i thought was happening,

but didnt know the actual mechanics. And sulfa. And Oxalate. It seems to me

oxalate also displaces iodine from cells, like other halides. And it effects

enzyme cofactors. Something i think alot of us and our kids share.

Which leads me to ask is oxalate ever good?

Are you finding lots of people are having the oxalate issue? Not just in the

autism community?

It seems to be my conclusion that the Low Oxalate diet has created better iodine

utilization. You are seeing lots of improvement in many areas. Improvement

Similiar to those on the iodine and thyroid boards are seeing with iodine

supplementation and/or avoiding goitrogenic foods.

So it seems safe to conclude that both the diet and the supplementation/avoiding

goitrogens seem to help the utilization of iodine. Correct me if i am wrong!

Are there any doing the low oxalate diet also using iodine? Have you seen more

improvement when both are done (if you have). Less?

Is there a specific known reason some bodies cant get rid of oxalates? That

might be an easy question to google but figure you would know best.

Does a low oxalate diet eventually correct the problem and then a regular diet

can be eaten? (Wondering if by creating better utilization eventually corrects

the problem as seen with the iodine people).

Is it just the lowering of oxalate foods that bring the elimination of symptoms

or also improved overall nutrition with both food and supplements?

Do you think oxalate is basically a halide?

So many questions! Hope you dont mind :-)

Cheryl

>

> ,

>

> Can I try and tie these things together? You may not know this, but iodine is

another one of the ions that moves across the cell membrane using a

sulfate/oxalate exchanger.

>

> This class of transporters give signals that regulate the cystic fibrosis

transporter. This CFTR transporter regulates fluid secretion in the gut and in

the mucus membranes (and pretty much every secretory organ including the

kidneys).

>

> So unexpectedly high or low levels of sulfate, iodine or oxalate may change

the regulation of the cystic fibrosis transporter, but indirectly. When the

cystic fibrosis transporter function is entirely lost (as in the disease by the

same name), the lungs have very gunky, globby mucus because the mucus is low in

fluid, and that makes it more easily infected.

>

> In this area, an avalanche of brand new basic science research in the last

three years has completely changed how scientists understand the regulation of

fluid and pH,and how cells of the gut and lungs protect themselves from

infection. The DAN! doctors don't know this new material yet, but they will

soon, hopefully!

>

> So, , the way these transporters work, it makes sense why adding in

higher levels of iodine might cause nasal drip, because it might change how much

fluid is crossing at the cystic fibrosis transporter.

>

> The shared use of the same ion transporter may be telling us that high oxalate

diets would alter the absorption of iodine. It is all an issue of quantity on

each side of the cell membrane, and how things are regulated together.

>

> People with cystic fibrosis are also very prone to infection because the

missing CFTR transporter cuts off the transport of thiocyanate and glutathione

into the mucus layer. Thiocyanate is being secreted there because it is quickly

converted right outside the cell into an antimicrobial, which is the second

reason those with CF get terrible lung infections and have bad guts, because

their secretion of thiocyanate is impaired.

>

> What does this have to do with autism?

>

> Dr. Rosemary Waring about twelve years ago found that the thiocyanate was also

extremely low in autism in urine. This suggests that abnormal function of the

sulfate/oxalate exchanger may be creating the perfect breeding ground for

dysbiosis that would only temporarily be helped by antibiotics or by other

antimicrobials because the drugs can kill the bugs, but cannot solve the problem

that got the bugs disordered in the first place.

>

> This is the area of science that our project at ARI thinks explains why people

reducing oxalate in the diet see the amazing improvements in dysbiosis and why

many can finally get off the " anti-fungal parade " .

>

> Anyway, , because these ions share transport, this is why something being

physiologically low (like sulfate or iodine) while something else is

physiologically higher than expected (like oxalate) would change the regulation

of fluid in the gut, the kidneys and the lungs.

>

> But lets talk about the bedwetting. When the body is detoxifying oxalate, some

boys will have accidents again at night until the dump is over. We've found

that after the body detoxifies from stored oxalate over time, it is very common

for those who weren't potty trained before to become potty trained. We've even

seen older children develop urinary control including stopping bedwetting.

>

> What about the fever? We sometimes see very high fevers accompanying dumping

on our listserve. We don't yet understand WHY this happens, but we also often

have parents saying their kids seem better while it is going on. Nighttime

fevers can be a sign of a dysregulation that DAN! doctor and thiamine expert,

Derrick Lonsdale, has reported happening in children that is treated with

thiamine. (see below) Thiamine deficiency increases the body making its own

oxalate because of impairing the mitochondrial enzyme, alpha

ketoglutarate:glyoxylate carboligase.

>

> You might find taking thiamine would help the fever. I hadn't thought about

this until now!

>

> The body has a " set point " that measures blood oxalate levels (not urinary

levels which might not " match " ). When oxalate in blood gets too high, if things

are working right, it causes the body to turn on oxalate protective mechanisms

which are what may induce a dump. You don't have to be low oxalate for that to

happen, because the " switch " doesn't care WHERE the oxalate came from.

>

> When you are eating high oxalate, the oxalate you are dumping may have come

recently from your diet. When your diet is low in oxalate, the increases of

blood oxalate only happen when the cells of the body start to clear oxalate,

releasing oxalate to the blood for disposal.

>

> Sometimes, these levels of freed oxalate can be extraordinarily high, and

until the oxalate clears during the dump, there are symptoms it brings on, but

as soon as it is cleared, if that was the only source of oxalate, then you see

the improvements.

>

> I hope this explains why these things might happen together. For more info,

or just to talk about these issues with experienced moms and dads who have seen

the same sorts of things in their children, join the support group

(Trying_Low_Oxalates ) that is linked to our website at

lowoxalate.info. It now has more than 3500 members.

>

> lowoxalate.info

> Head of the Autism Oxalate Project at ARI

>

> PS. Years ago, a child in our neighborhood had very high night fevers and