Nose Growth/Will Photoderm help this?Anyone have info on Factor Vllla

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1 : J Am Acad Dermatol 2000 Mar;42(3):468-72Related Articles, Books,

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The clinicopathologic spectrum of rhinophyma.

Aloi F, Tomasini C, Soro E, Pippione M

Department of Dermatology, University of Turin, Italy.

We report the results of a clinicopathologic study of 17 patients with

rhinophyma in different stages of evolution, with particular attention

paid to the severe form of this disease. On the basis of clinical

features, we identified 2 groups of patients: the first group (12/17

patients) included patients with the common form of rhinophyma, whereas

the second one (5/17 patients) included patients with the severe form of

the disease. There was no link between the clinical aspect and the

duration of the disease. Microscopic examination of specimens obtained

from the classic type of rhinophyma substantially showed the

histopathologic features of fully developed rosacea, except for the

presence of prominent sebaceous hyperplasia. The second group showed a

very different histologic pattern displaying marked dermal thickness,

absence of folliculosebaceous structures, sclerotic collagen bundles

with large amounts of mucin, and spreading telangiectasia. The

inflammatory infiltrate was inconspicuous, with numerous interstitial

spindle and bizarre cells. Most of the interstitial cells were reactive

to factor XIIIa. The severe form of rhinophyma shares many histologic

characteristics with elephantiasis caused by chronic lymphedema.