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Gillian, maybe you could get your doctor to contact Dr. Kastner at NIH because

as far as I know, if Colchicine works for your son, that's supposed to be the

equivalent of a pretty firm diagnosis for FMF. Unfortunately, The testing isn't

100 percent reliable either. My son has yet to test positive for FMF or any of

the other genetic dosorders but NIH considers that his symptoms and his response

to Colcicine are a diagnosis in them selves.

Pat, mom to PJ, 14 year old, FMF

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" Thank you Pat! You are a wealth of information! "

LOL! Yeah, experience does that to you! Research, research and more research!

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We just took our son to a pediatric neurologist and he assured us that Ian's

temps in the 105's and 106's do not hurt his brain unless we can't get them

down. It seems hard to believe, but all the docs seem to agree.

carol

Re: Colchicine

Question to anyone who knows. I know they say the high temps will

not hurt

small children and there bodies are made to handle it even kids without .

at what age are they not considered able to handle a high temp. when I took

alfonso to the ER once with a 103 temp they told me anything that high they

take very seriously. and that was low for one of his temps .. are these 105

and 106 temps frying him at this older age just a thought maybe someone has

input take care chicks

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To my knowledge it only comes in pill form. I've gotten grief for this (mostly

from my inlaws:) but we put it in 1/2 a spoonful of chocolate syrup and he takes

it fine. To me if that's all I have to do to take a pill two times a day it's

worth it. There is a way to mix it in water, but I haven't had to do that.

Taryn

Mom to Evan 4 y.o. Clinical FMF

Re: Colchicine

My son was tested for TRAPS and it was negative. The

doctor took weekly blood draws for a month to test for

cyclic neutropenia, and that came back negative as

well. So our doctor figures that Kai has periodic

fever syndrome, but he found that Colchicine seems to

work really well with it.

It is reassuring to hear that the side effects aren't

too bad. How do you give the medicine to your son --

is it in pill form? Does he take it pretty well or is

it a fight?

Thanks!

Gillian

--- molson77@... wrote:

> My son, Evan/4 y.o., is on colchicine. His doctors

> believe he has Familial

> Mediterranean Fever although his genetic testing was

> negative. We were

> apprehensive about colchicine at first. After

> researching and discussing in

> detail with our ped. rheum. we found there to be

> minimal side effects (diarrhea

> until correct dosage is found) and no long term

> effects on the body. He is on

> .3 mg in the am and .6mg in the pm. Evan is now

> going on 14 weeks without a

> flare (he was getting one every 3 weeks like

> clockwork) and we have a clinical

> diagnosis of FMF since the colchicine seems to be

> helping. Hope this helps.

> Let us know what you decide.

>

> Taryn

> Mom to Evan, 4 y.o., FMF

>

>

>

> ************************************** See what's

> free at http://www.aol.com.

>

>

> [Non-text portions of this message have been

> removed]

>

>

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  • 4 months later...

What do you give your daughter to drink when she is fevering?? I

give my son gatorade often, so he doesn't dehydrate. If I give him

any gatorades that are colored green, blue, or purple, we get the

bright green BM. Just a thought!!

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is on her third month of Colchicine. For the first month or so,

it upset her stomach a lot. Now, there are no side effects but the

Colchicine is not helping the fevers. is still fevering every 2-

3 weeks. Before Colchicine, she was on Cimetidine and that didn't

help either -except for one 6 week break. We visit Texas Children's

in Houston again next month for a re-evaluation. Good luck with the

Colchicine. I hope it helps for your child :-)

Misty

Mom to Zachary 8.5 years and 5 years ()

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is on her third month of Colchicine. For the first month or so,

it upset her stomach a lot. Now, there are no side effects but the

Colchicine is not helping the fevers. is still fevering every 2-

3 weeks. Before Colchicine, she was on Cimetidine and that didn't

help either -except for one 6 week break. We visit Texas Children's

in Houston again next month for a re-evaluation. Good luck with the

Colchicine. I hope it helps for your child :-)

Misty

Mom to Zachary 8.5 years and 5 years ()

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  • 3 months later...

FRAN thank-you for getting back to me i was wondering why do you think the mayo

clinic just told me that more than likely he has is it only because he

did test negative for fmf . i do know that he does not follow all of the

symptoms of phapa and we are also struggling with exspressive and receptive

lanuage delay and he will be 3 at the end of feb. i took him off of colchrine 5

days ago and today he did get a fever so still know he still has the fevers and

that the colchrine works please give me your imput emily

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Hi

Re: the language delay. My son has an expressive delay, but they still consider

him to have . Although growth and development being normal is an important

aspect of , I do believe you can have the speech delay and still have

. Speech delays impact up to 10-12% of young children, so it is quite

possible that our children are just part of that statistic - with the cyclical

fever piece, whether it be , FMF etc, being a separate variable in all of

this.

Regards,

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Hi

Re: the language delay. My son has an expressive delay, but they still consider

him to have . Although growth and development being normal is an important

aspect of , I do believe you can have the speech delay and still have

. Speech delays impact up to 10-12% of young children, so it is quite

possible that our children are just part of that statistic - with the cyclical

fever piece, whether it be , FMF etc, being a separate variable in all of

this.

Regards,

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Hi

Re: the language delay. My son has an expressive delay, but they still consider

him to have . Although growth and development being normal is an important

aspect of , I do believe you can have the speech delay and still have

. Speech delays impact up to 10-12% of young children, so it is quite

possible that our children are just part of that statistic - with the cyclical

fever piece, whether it be , FMF etc, being a separate variable in all of

this.

Regards,

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I am not fran, but would like to answer a quick question. I was told that Pfapa

is diagnossed when they have the periodic fevers and mouth/throat sores. We did

all genetic testing and was negative for all, so since he was negative and he

has mouth/throat sores, they call it . Have they discussed tonsillectomy

with you????

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  • 1 year later...
Guest guest

Hello, my son has been on colchicine since the end of November. He did get a

fever in December and in January on schedule. However, the fever only lasted

about 2 days and only got as high as 101 for one day. Normal fever would range

5 to 8 days, and go to 104-105 about every 21 days. We are now 70 days fever

free. My son does still get some symptoms in which we think a fever is coming

on, but nothing ever develops. So far the colchicine has been working great!!!

We get labs done every 3 months, and everything came back good. Just out of

curiosity how old is your child and what dose of colchicine is he on? My son is

3years old and is on .3mg everyday. Good Luck, and keep us posted on your

childs progress.

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Hi Debbie,

Our son started on colchicine back in May of last year. His doctors warned us

that it may take until June or July before we saw effects. However, we only saw

two very mild cases in July and August, I believe. That said, he has

occasionally had achy joints around the times he probably *should* have had his

fevers. All told, and we learned the hard way, DO NOT miss a dose. He had one

of his worst fever bouts this January due to a missed dose by only 12 hours.

Good luck!

Liz

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Guest guest

Hello.

My daughter started colchicine in Jan. The doc perscribed .3 twice daily for

out 2 and half yr old. I thought this was too much so give it to her once a day.

After a couple weeks her hair started to grow (like crazy! She has not had much

and actually lost a lot over the past 18 months.) And she has gone on a growth

spurt! She did have a high fever episode but it came at 6 weeks rather than 4

weeks. I am not sure if it is the med or coincidence! I am still going to give

it to her and see what happens next month.

Good Luck!

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Hi ,

Our son is almost 27 months old, and is on 0.6 mg once a day. His labwork

always comes out well, and he doesn't have loose stools, which can be a side

effect.

Liz

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Hi ,

Our son is almost 27 months old, and is on 0.6 mg once a day. His labwork

always comes out well, and he doesn't have loose stools, which can be a side

effect.

Liz

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Hi --My son is 3.5 years old.  He is on .6 mg of colchicine every day. 

He's been taking it for about 3 weeks.  He usually gets fevers every 18-24

days--and this one was in 31days!  and it was much milder--only ranged betweed

100 - 103!  He also had less stomach pains.  We haven't been instructed to get

any labs yet--what are the labs for?  I'd like to ask his Dr. about getting

checked if needed.  Thank you! 

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Hi --My son is 3.5 years old.  He is on .6 mg of colchicine every day. 

He's been taking it for about 3 weeks.  He usually gets fevers every 18-24

days--and this one was in 31days!  and it was much milder--only ranged betweed

100 - 103!  He also had less stomach pains.  We haven't been instructed to get

any labs yet--what are the labs for?  I'd like to ask his Dr. about getting

checked if needed.  Thank you! 

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Melody has been fevering since 3 months. She started on colchicine around 1 1/2

yrs. and we felt it was no help. Last March after a horrible episode we were

desperate and decided to try again, and was perscribed 2 1/2 tabs. Only she

wasn't yet 2 and couldn't swallow the pills. The doctor suggested finding a

" mom and pop " pharmacy that could make it into a liquid. This was a wast of

time. She continued to fever on regular schedule. I was frustrated because the

liquid could only be made in a 10 day supply. Then one day in August Melody

asked if she could swallow the pills, and she has only fevered two times related

to bad colds. The fever was only 100 - 101, but at times she does complain of

mild headache, or sotomache.

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Melody has been fevering since 3 months. She started on colchicine around 1 1/2

yrs. and we felt it was no help. Last March after a horrible episode we were

desperate and decided to try again, and was perscribed 2 1/2 tabs. Only she

wasn't yet 2 and couldn't swallow the pills. The doctor suggested finding a

" mom and pop " pharmacy that could make it into a liquid. This was a wast of

time. She continued to fever on regular schedule. I was frustrated because the

liquid could only be made in a 10 day supply. Then one day in August Melody

asked if she could swallow the pills, and she has only fevered two times related

to bad colds. The fever was only 100 - 101, but at times she does complain of

mild headache, or sotomache.

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Guest guest

Hi Debbie,

The labs are pulled to make sure that the drug is not overloading his liver and

causing the liver enzymes (AST, ALT) to increase. It is a pretty common side

effect of many drugs, and to remedy it, it usually only has to have the dosage

decreased a little bit. We also have a CRP and ESR drawn as well in order to

make sure there is not any inflammation present, which may cause amyloidosis if

my son were to eventually be diagnosed with FMF. The fact that his inflammation

levels are normal also suggests that the colchicine is working in his case! :)

Liz

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  • 9 months later...

Has anyone heard of using colchicine (gout medicine - blocks uric acid

production/retention) as a treatment of mycoplasma? I just found an article on

Gouty Arthritis

(http://www.garynull.com/Documents/Arthritis/Gouty_Arthritis.htm) while I was

investigating the protein " ubiquitin " which, apparently, is used by the body to

control/dissolve other proteins. It would seem that one of the theories about RA

is that certain fungi and/or bacteria (mycoplasma, ie) can set off the over

production of ubiquitin as a result of their release of toxins. This results in

unwanted tissue and immune destruction. The article seems to have been written

from a dental point of view but hey, ... it caught my eye.

Rick

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