Re: Minocycline and methotrexate

[Guest guest]

I just want to commend you for being such a caring doctor, I've found that very

rare indeed.

I took myself off Methotrexate too, ooooouuuuucccccchhhhh!. It was so bad I am

terrified to ever go off of it again.

Sue

---- doolan_a <doolan_a@...> wrote:

> Hi Guys,

>

> Australian naturopath here. I have a client who presented some time ago with

newly diagnosed RA. He obtained minocycline from his GP who was not very

knowlegable about AP. He had been taking methotrexate. He rang me to tell me

that he has weaned himself off methotrexate over the last three weeks and had

been taking minocycline 50mg x 2/day everyday. He is in significantly more pain

which is making if difficult for him to work. I have initially advised him to

go to 100mg minocycline M, W and F and he will contact me in one week. I also

advised that things can get worse before they get better. I am concerned that he

took himself off methotrexate without a doctor's assistance and that I would

have preferred to have seen his pain levels under control before he reduce the

methotrexate. I am thinking an appointment with the AP doctor here could be the

most appropriate next step. I would really appreciate your input on this

situation.

>

> Kind regards,

> .

>

[Guest guest]

Hi, I think your client needs to go to his doctor immediately since it is going

to be real painful for them quitting Methotrexate all of a sudden. I myself quit

Methotrexate after using Mino for a few weeks. I was one of the lucky ones that

did not get pain initiallly after quitting Methotrexate. Now its a different

story and I wish I would get Methotrexate again with Mino. Combination of both

of them kept the pain away

> Hi Guys,

>

> Australian naturopath here. I have a client who presented some time ago with

newly diagnosed RA. He obtained minocycline from his GP who was not very

knowlegable about AP. He had been taking methotrexate. He rang me to tell me

that he has weaned himself off methotrexate over the last three weeks and had

been taking minocycline 50mg x 2/day everyday. He is in significantly more pain

which is making if difficult for him to work. I have initially advised him to go

to 100mg minocycline M, W and F and he will contact me in one week. I also

advised that things can get worse before they get better. I am concerned that he

took himself off methotrexate without a doctor's assistance and that I would

have preferred to have seen his pain levels under control before he reduce the

methotrexate. I am thinking an appointment with the AP doctor here could be the

most appropriate next step. I would really appreciate your input on this

situation.

>

> Kind regards,

> .

>

[Guest guest]

Hi

Think that alot of experienced AP patients these days say that it's best to stay

on DMARDS such as mtx, if someone is already taking it, until through the worst

of herxing and they start to notice some improvement.Your patient ideally should

then have a doc's advice on weaning off slowly.

Coming off DMARDS in order to start AP could mean that the patient will possibly

both be herxing AND experiencing rebound from the cessation of mtx - which could

be mega-painful (unless, of course, there's not an option). BTW, some people

who are on DMARDs won't experience much of a herx due to the immune-suppression.

Incidentally, The Historical Protocol approach was to have a wash-out period

from drugs such as mtx before starting AP. See

http://www.roadback.org/index.cfm?fuseaction=studies.display & display_id=184#Anch\

or-Washout-48213

Lynnie