Guest guest Posted October 6, 2001 Report Share Posted October 6, 2001 A mast cell degranulator causes mast cells to degranulate. Myra explains this process best: " The mechanics behind hiving is called mast cell degranulation. Which means certain little white blood cells are going bonkers and firing histamine. Mast cells fire because of antigens (invaders, real or " perceived " ) which come into your body either by contact (skin), inhalation or digestion. Or by antigens which are produced within the body by other factors, such as inflamation or systemic illness such as cancer, thyroid or lupus. Besides histamine, mast cells also " fire " heparin, chrondrotin sulfates, neutral proteases, acid hydrolases and other enzemes. On the surface of these mast cells are little receptors for IgE (immunoglobulin E antibody). Think " velcro " . When an antigen comes into the body it " sticks " to the velcro, when the mast cell gets loaded it starts " firing " its weapons (degranulation) and it encourages other mast cells as well as other inflamatory cells (basophils and leukotrines) to fire also. Degranulation causes hives because the contents of the mast cell causes vaso-dialation ( the capillaries increase in diameter) and leak fluid into the surrounding tissues which produces swelling and the histamine infusion into the tissues produce hives. The principal approach is to control mast cells, by either controlling the IgE stimulation or control the histamine being leaked. Granted this is treating the symptom not the cause, but until a cause is determined it is in your best interest to try to gain some control over the symptoms. " Air hugs, Jackie Life is tough, but I'm tougher. ----Original Message Follows---- Reply-To: urticaria To: urticaria Subject: Re: Cara/MSG Date: Sat, 06 Oct 2001 19:11:43 -0700 mast cell degranulator What does this mean? Cara, Cara's Poetry Cove http://www.snowcrest.net/cara ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ If you do wish to unsubscribe then you can click on the following link: urticaria-unsubscribeegroups ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ This list is in the service of those who suffer from Chronic Urticaria (hives). We strive to support and lift each other as a worldwide cyber-family. We share whatever needs to be shared to help one another in our struggle with Chronic Urticria. Information provided in this forum is not to be taken as medical advice. Always consult your health professional before trying anything new. Any posting that is off the main topic of Chronic Urticaria, we post with a prefix of NCU -. This is done out of respect for those who do not wish to read such postings. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2001 Report Share Posted October 6, 2001 Thank you for the explaination Jackie, my dictionary says de·gran·u·la·tion (d¶-gr²n”y…-l³“sh…n) n. The process of losing granules. So I am wondering are the histamines that make the hives supposed to stay in the mast cells or do the mast cells produce histamines when " triggered " such as in what ever we do that causes them? I mean to we have to many histamines or to many histamines in the wrong places like on the loose when they should be in the mast cells? Cara, Cara's Poetry Cove http://www.snowcrest.net/cara Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2001 Report Share Posted October 7, 2001 Cara, Hopefully Myra will jump in here, since she understands this biomechanical stuff better than I do. If I remember everything I've read correctly, the problem is an overabundance of mast cells and/or mast cell activity. If the problem is too many mast cells, then the body is being overwhelmed by them and their activity, which is what happens in mastocytosis. If it is too much activity of the mast cells, then SOMETHING (illness, infection, allergy, whatever) is making these little guys fire off. Either way, when the mast cells degranulate, histamine is one of the products they release. Degranulation is their job, part of our immune system's defenses, but for some reason they are doing it too well. Air hugs, Jackie Life is tough, but I'm tougher. ----Original Message Follows---- Reply-To: urticaria To: urticaria Subject: Re: mast cell degranulation Date: Sat, 06 Oct 2001 21:03:05 -0700 Thank you for the explaination Jackie, my dictionary says de·gran·u·la·tion (d¶-gr²n”y…-l³“sh…n) n. The process of losing granules. So I am wondering are the histamines that make the hives supposed to stay in the mast cells or do the mast cells produce histamines when " triggered " such as in what ever we do that causes them? I mean to we have to many histamines or to many histamines in the wrong places like on the loose when they should be in the mast cells? Cara, Cara's Poetry Cove http://www.snowcrest.net/cara _________________________________________________________________ Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2001 Report Share Posted October 7, 2001 Jackie, Ahhhhhhhhhh, I understand more now... So it's too many mast cells, no wonder anti histamines don't work, we need anti mastamines! At 02:50 PM 10/7/2001 -0700, you wrote: >Cara, > >Hopefully Myra will jump in here, since she understands this biomechanical >stuff better than I do. If I remember everything I've read correctly, the >problem is an overabundance of mast cells and/or mast cell activity. If the >problem is too many mast cells, then the body is being overwhelmed by them >and their activity, which is what happens in mastocytosis. If it is too much >activity of the mast cells, then SOMETHING (illness, infection, allergy, >whatever) is making these little guys fire off. Either way, when the mast >cells degranulate, histamine is one of the products they release. >Degranulation is their job, part of our immune system's defenses, but for >some reason they are doing it too well. > >Air hugs, >Jackie > > >Life is tough, but I'm tougher. > > > > >----Original Message Follows---- > >Reply-To: urticaria >To: urticaria >Subject: Re: mast cell degranulation >Date: Sat, 06 Oct 2001 21:03:05 -0700 > >Thank you for the explaination Jackie, my dictionary says de·gran·u·la·tion >(d¶-gr²n”y…-l³“sh…n) n. The process of losing granules. > >So I am wondering are the histamines that make the hives supposed to stay in >the mast cells or do the mast cells produce histamines when " triggered " >such as >in what ever we do that causes them? > >I mean to we have to many histamines or to many histamines in the wrong >places >like on the loose when they should be in the mast cells? > > > >Cara, > >Cara's Poetry Cove >http://www.snowcrest.net/cara > > >_________________________________________________________________ >Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp > > > >~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ >If you do wish to unsubscribe then you can click on the following link: > urticaria-unsubscribeegroups >~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ > >This list is in the service of those who suffer from Chronic Urticaria (hives). We strive to support and lift each other as a worldwide cyber-family. > >We share whatever needs to be shared to help one another in our struggle with Chronic Urticria. Information provided in this forum is not to be taken as medical advice. Always consult your health professional before trying anything new. > >Any posting that is off the main topic of Chronic Urticaria, we post with a prefix of NCU -. This is done out of respect for those who do not wish to read such postings. > > Quote Link to comment Share on other sites More sharing options...
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