Guest guest Posted March 2, 2010 Report Share Posted March 2, 2010 Ute didn't quite say what test was in the upper range. I'm wondering if she is referring to TSH, or ft3. I may have missed it - sorry. But it could be important to figuring it out. Because high TSH and high ft3 mean opposite things. Amy Harald Weiss, Technical Marketing Group wrote: > > > Ute, > > Hyperthyroid means too much thyroid function, while hypothyroid means > too little thyroid function. > > A brief Google search for > +thyroid +minocycline > brings up pages which include the following: > > http://www.springerlink.com/content/0414432475vq7244/ > <http://www.springerlink.com/content/0414432475vq7244/> > http://www.liebertonline.com/doi/abs/10.1089/thy.2008.0048?cookieSet=1 & journalCo\ de=thy > <http://www.liebertonline.com/doi/abs/10.1089/thy.2008.0048?cookieSet=1 & journalC\ ode=thy> > http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282004%29128%3C355\ %3APQCTIP%3E2.0.CO%3B2 > <http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282004%29128%3C35\ 5%3APQCTIP%3E2.0.CO%3B2> > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900569/ > <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900569/> > http://linkinghub.elsevier.com/retrieve/pii/S0149794401004767 > <http://linkinghub.elsevier.com/retrieve/pii/S0149794401004767> > > The above links, as well as warning labels associated with > minocycline, indicate that minocycline is often associated with black > pigmentation of the thyroid gland and can be associated with hard > thyroid nodules and papillary carcinoma. > > The page http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6854 > <http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6854> > http://www.globalphar.com/PI/PI_Minocycline%20Hydrochloride.pdf > <http://www.globalphar.com/PI/PI_Minocycline%20Hydrochloride.pdf> > and other pages include the following text: > > " Carcinogenesis, Mutagenesis, Impairment of Fertility > > Dietary administration of minocycline in long term tumorigenicity > studies in rats resulted in evidence of thyroid tumor production. > Minocycline has also been found to produce thyroid hyperplasia in > rats and dogs. In addition, there has been evidence of oncogenic > activity in rats in studies with a related antibiotic, > oxytetracycline (ie, adrenal and pituitary tumors). Likewise, > although mutagenicity studies of minocycline have not been conducted, > positive results in in vitro mammalian cell assays (ie, mouse > lymphoma and Chinese hamster lung cells) have been reported for > related antibiotics (tetracycline hydrochloride and oxytetracycline). > Segment I (fertility and general reproduction) studies have provided > evidence that minocycline impairs fertility in male rats. " > > Now to your main question. A brief Google search for > +thyroid +doxycycline > brings up pages which include the following: > > http://www.ncbi.nlm.nih.gov/pubmed/16477607 > <http://www.ncbi.nlm.nih.gov/pubmed/16477607> > http://www.rxlist.com/oracea-drug.htm > <http://www.rxlist.com/oracea-drug.htm> (click on the 4th tab) > " Carcinogenesis, Mutagenesis, Impairment of Fertility. " > > Both minocycline and doxycycline are tetracycline class drugs > antibiotics; however, there are many fewer web pages for doxycycline > on blackening of the thyroid and thyroid tumors than for minocycline. > > I hope that this answers some of your questions. > > Sincerely, Harald > > At 04:06 PM 3/2/2010, Ute wrote: > >Hello Herald, > >I know you did a lot of research regarding thyroid and mino a while > >back. My latest blood test showed that my thyroid function is is on > >the upper range of normal for hyperthyroid. I am thinking of > >discontinuing the Mino for a while to see if that will come down. Do > >you know if Doxycyline has the same effect? > >Take care, > >Ute > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 3, 2010 Report Share Posted March 3, 2010 Hi Amy, I had e-mailed Harald off list, so you actually didn't miss my original post But I guess it is good information for the list. My TSH is normal, but the fT3 was on the borderline normal/high. I have been on Mino for 12 years, so it may be time to switch to Doxy to see if that brings the values down. I don't have symptoms of being hyperthyroid. I also want to point out that the possible side effects of Minocin are real and we should be on the lookout for abnormalities while on this drug, they are considered rare. The staining of the thyroid seems more common, but it seems not known if there are bad effects because of that. Anytime we take a drug we should consider risk/benefit. So, I consider where I would be had I not chosen any treatment for RA ? What would my health be like if I had chosen 12 years of the " toxic " drugs with many more possible serious side effects? Take care, Ute Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 3, 2010 Report Share Posted March 3, 2010 I appreciate your story, and all info from Harald as well. I do not dismiss effects of mino, or any other medication. I am glad you do not have symptoms of being hyper. FWIW, my TSH was a normal 1.0, while while I watched my ft3 fell to the bottom of the range, and the cause may have been medication, but I don't know. But my TSH does not respond to high or low levels of ft3 (as is should). Have you & Harald already have considered the possibility of acetyl-l-carnitine, which has a reputation for removing lipofucsin (pigment/staining), particularly in the brain. Not sure if it's the same stain though. Amy Ute wrote: > > > Hi Amy, > I had e-mailed Harald off list, so you actually didn't miss my > original post > But I guess it is good information for the list. > My TSH is normal, but the fT3 was on the borderline normal/high. > I have been on Mino for 12 years, so it may be time to switch to Doxy to > see if that brings the values down. I don't have symptoms of being > hyperthyroid. > > I also want to point out that the possible side effects of Minocin are > real > and we should be on the lookout for abnormalities while on this drug, > they > are considered rare. The staining of the thyroid seems more common, > but it > seems not known if there are bad effects because of that. Anytime we > take a > drug we should consider risk/benefit. > So, I consider where I would be had I not chosen any treatment for RA ? > What would my health be like if I had chosen 12 years of the " toxic " > drugs > with many more possible serious side effects? > > Take care, > Ute > > Quote Link to comment Share on other sites More sharing options...
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