Re: synoval lining inflamation

[Guest guest]

Hi Eva, Glad you and Burl got home safely.  it was a wonderful Sunday afternoon

and evening that we had just relaxing and sharing.  I'm glad we didn't go

running around town.  I was exhausted from the week before.  Did planty of

running while my cousin was here.  On Monday, I vegged out and hung around the

house relaxing also and felt renewed going back to work on Tuesday morning.  Now

I wish it were Sunday again.  I got spoiled lounging around.  We are busy going

on with our plans to start a business of our own.  Putting ideas together and

gathering funding for my project.  It will probably take me a year to launch,

but I am a patient lady.  Take care and hope your hands heal up.  They looked so

sore. BTW, I saved the articles that you sent.  Very Interesting. Best to you,

Dolores & Mike 

From: Eva Holloway <holloway-eva@...>

Subject: rheumatic synoval lining inflamation

rheumatic

Date: Monday, September 1, 2008, 6:07 PM

Dolores and Mike,

 

here is a little info on the problem I told you I have with my hands.

 

Key proteins identified in inflammation of joints

     Hopkins medical researchers have found a key link in the

chain reaction that causes inflammation of the lining of the

joints in arthritis. The discovery may aid the search for drugs

that suppress or control these events before the joints are

damaged.

     The scientists found that activation of two types of

molecules called G-proteins is part of a cascade of signals that

causes the lining of the joints to become inflamed. The reaction

begins when bradykinin, a small protein, binds with special

receptors on the outside of the cells making up the lining of the

joints. The G-proteins are in the cellular " skin " of this lining,

called the synovium, which is rich in bradykinin receptors.

     " This study provides the first direct evidence that

G-proteins connect the pathways to bradykinin receptors in human

synovial cells, " said Helen , the study's lead author.

" Now the goal is to develop strategies to block the pathways and

to develop new anti-inflammatory drugs that can do that job. "

     Currently available anti-inflammatory drugs for the most

part have been disappointing, making it logical to investigate

other ways to prevent or control inflammation, said. 

------------ --------- --------- --------- --------- --------- -

anyway, Burl and I had a great time in Corpus Christi and it was nice seeing you

and you doing so well. I am looking forward of getting well too soon. Guess as I

told you I am a little impatient and want to get well now, but I can wait a

little while longer.

We got home before 11 am this morning. No problem with the weather.

Take care,

Eva and Burl

[Guest guest]

Don't the biologics work the same way....by blocking a protein that causes

inflammation?

Sue

rheumatic synoval lining inflamation

Dolores and Mike,

here is a little info on the problem I told you I have with my hands.

Key proteins identified in inflammation of joints

Hopkins medical researchers have found a key link in the

chain reaction that causes inflammation of the lining of the

joints in arthritis. The discovery may aid the search for drugs

that suppress or control these events before the joints are

damaged.

The scientists found that activation of two types of

molecules called G-proteins is part of a cascade of signals that

causes the lining of the joints to become inflamed. The reaction

begins when bradykinin, a small protein, binds with special

receptors on the outside of the cells making up the lining of the

joints. The G-proteins are in the cellular " skin " of this lining,

called the synovium, which is rich in bradykinin receptors.

" This study provides the first direct evidence that

G-proteins connect the pathways to bradykinin receptors in human

synovial cells, " said Helen , the study's lead author.

" Now the goal is to develop strategies to block the pathways and

to develop new anti-inflammatory drugs that can do that job. "

Currently available anti-inflammatory drugs for the most

part have been disappointing, making it logical to investigate

other ways to prevent or control inflammation, said.

----------------------------------------------------------

anyway, Burl and I had a great time in Corpus Christi and it was nice seeing

you and you doing so well. I am looking forward of getting well too soon. Guess

as I told you I am a little impatient and want to get well now, but I can wait a

little while longer.

We got home before 11 am this morning. No problem with the weather.

Take care,

Eva and Burl

[Guest guest]

Sue,

 

can you explain by biologics! I have synovial lining inflammation and want to

get it under control. my hands are always hot and look swollen. Some days they

hurt a lot. I don't have any deformities.

 

Thanks,

Eva

From: Sue Emrick <semrick@...>

Subject: Re: rheumatic synoval lining inflamation

rheumatic

Date: Thursday, September 4, 2008, 6:46 PM

Don't the biologics work the same way....by blocking a protein that causes

inflammation?

Sue

rheumatic synoval lining inflamation

Dolores and Mike,

here is a little info on the problem I told you I have with my hands.

Key proteins identified in inflammation of joints

Hopkins medical researchers have found a key link in the

chain reaction that causes inflammation of the lining of the

joints in arthritis. The discovery may aid the search for drugs

that suppress or control these events before the joints are

damaged.

The scientists found that activation of two types of

molecules called G-proteins is part of a cascade of signals that

causes the lining of the joints to become inflamed. The reaction

begins when bradykinin, a small protein, binds with special

receptors on the outside of the cells making up the lining of the

joints. The G-proteins are in the cellular " skin " of this lining,

called the synovium, which is rich in bradykinin receptors.

" This study provides the first direct evidence that

G-proteins connect the pathways to bradykinin receptors in human

synovial cells, " said Helen , the study's lead author.

" Now the goal is to develop strategies to block the pathways and

to develop new anti-inflammatory drugs that can do that job. "

Currently available anti-inflammatory drugs for the most

part have been disappointing, making it logical to investigate

other ways to prevent or control inflammation, said.

------------ --------- --------- --------- --------- --------- -

anyway, Burl and I had a great time in Corpus Christi and it was nice seeing you

and you doing so well. I am looking forward of getting well too soon. Guess as I

told you I am a little impatient and want to get well now, but I can wait a

little while longer.

We got home before 11 am this morning. No problem with the weather.

Take care,

Eva and Burl

[Guest guest]

Eva, the biologics are Enbrel and Humira. I think there are more but can't

remember the names. My hands are the worst part of my RA too. Makes it hard

to do anything really. The inflammation got so bad that it caused Carpal Tunnel,

had that operation in the spring.

Sue

rheumatic synoval lining inflamation

Dolores and Mike,

here is a little info on the problem I told you I have with my hands.

Key proteins identified in inflammation of joints

Hopkins medical researchers have found a key link in the

chain reaction that causes inflammation of the lining of the

joints in arthritis. The discovery may aid the search for drugs

that suppress or control these events before the joints are

damaged.

The scientists found that activation of two types of

molecules called G-proteins is part of a cascade of signals that

causes the lining of the joints to become inflamed. The reaction

begins when bradykinin, a small protein, binds with special

receptors on the outside of the cells making up the lining of the

joints. The G-proteins are in the cellular " skin " of this lining,

called the synovium, which is rich in bradykinin receptors.

" This study provides the first direct evidence that

G-proteins connect the pathways to bradykinin receptors in human

synovial cells, " said Helen , the study's lead author.

" Now the goal is to develop strategies to block the pathways and

to develop new anti-inflammatory drugs that can do that job. "

Currently available anti-inflammatory drugs for the most

part have been disappointing, making it logical to investigate

other ways to prevent or control inflammation, said.

------------ --------- --------- --------- --------- --------- -

anyway, Burl and I had a great time in Corpus Christi and it was nice seeing

you and you doing so well. I am looking forward of getting well too soon. Guess

as I told you I am a little impatient and want to get well now, but I can wait a

little while longer.

We got home before 11 am this morning. No problem with the weather.

Take care,

Eva and Burl

[Guest guest]

Sue,

 

I tried Enbrel and became very ill, that is why I am on the AP program. I don't

want to go back where I was last year and in January. My rheumy even admitted to

me that the medications she had put me on had failed. She told me that after a

year of hell on the medications they told me would make me feel good.

 

Eva

From: Sue Emrick <semrickneo (DOT) rr.com>

Subject: Re: rheumatic synoval lining inflamation

rheumatic@grou ps.com

Date: Thursday, September 4, 2008, 6:46 PM

Don't the biologics work the same way....by blocking a protein that causes

inflammation?

Sue

rheumatic synoval lining inflamation

Dolores and Mike,

here is a little info on the problem I told you I have with my hands.

Key proteins identified in inflammation of joints

Hopkins medical researchers have found a key link in the

chain reaction that causes inflammation of the lining of the

joints in arthritis. The discovery may aid the search for drugs

that suppress or control these events before the joints are

damaged.

The scientists found that activation of two types of

molecules called G-proteins is part of a cascade of signals that

causes the lining of the joints to become inflamed. The reaction

begins when bradykinin, a small protein, binds with special

receptors on the outside of the cells making up the lining of the

joints. The G-proteins are in the cellular " skin " of this lining,

called the synovium, which is rich in bradykinin receptors.

" This study provides the first direct evidence that

G-proteins connect the pathways to bradykinin receptors in human

synovial cells, " said Helen , the study's lead author.

" Now the goal is to develop strategies to block the pathways and

to develop new anti-inflammatory drugs that can do that job. "

Currently available anti-inflammatory drugs for the most

part have been disappointing, making it logical to investigate

other ways to prevent or control inflammation, said.

------------ --------- --------- --------- --------- --------- -

anyway, Burl and I had a great time in Corpus Christi and it was nice seeing you

and you doing so well. I am looking forward of getting well too soon. Guess as I

told you I am a little impatient and want to get well now, but I can wait a

little while longer.

We got home before 11 am this morning. No problem with the weather.

Take care,

Eva and Burl

[Guest guest]

I am so glad you are doing well on the AP. I too tried AP for 1 1/2 years

without much improvement. I had to decide that with no quality of life and

raising by 2 boys I must try something else, thus I am now on Enbrel. I am

doing good on it so far and feel " normal " again. Hopefully when my boys are

older and I have time to tinker I will go back to AP. Any way we can get

better is great, the least toxic way is ideal but unfortunatley doesn't cut it

for all.

Continued success on AP,

Sue

rheumatic synoval lining inflamation

Dolores and Mike,

here is a little info on the problem I told you I have with my hands.

Key proteins identified in inflammation of joints

Hopkins medical researchers have found a key link in the

chain reaction that causes inflammation of the lining of the

joints in arthritis. The discovery may aid the search for drugs

that suppress or control these events before the joints are

damaged.

The scientists found that activation of two types of

molecules called G-proteins is part of a cascade of signals that

causes the lining of the joints to become inflamed. The reaction

begins when bradykinin, a small protein, binds with special

receptors on the outside of the cells making up the lining of the

joints. The G-proteins are in the cellular " skin " of this lining,

called the synovium, which is rich in bradykinin receptors.

" This study provides the first direct evidence that

G-proteins connect the pathways to bradykinin receptors in human

synovial cells, " said Helen , the study's lead author.

" Now the goal is to develop strategies to block the pathways and

to develop new anti-inflammatory drugs that can do that job. "

Currently available anti-inflammatory drugs for the most

part have been disappointing, making it logical to investigate

other ways to prevent or control inflammation, said.

------------ --------- --------- --------- --------- --------- -

anyway, Burl and I had a great time in Corpus Christi and it was nice seeing

you and you doing so well. I am looking forward of getting well too soon. Guess

as I told you I am a little impatient and want to get well now, but I can wait a

little while longer.

We got home before 11 am this morning. No problem with the weather.

Take care,

Eva and Burl