guaifenesin

[Guest guest]

Guaifenesin is being touted as a cure for Fibromyalgia. Simply put

Guaifenesin allows the body to eliminate from the bloodstream

certain minerals that appear to be in high concentration in muscles

and other tissue causing the problems and pain. When these

minerals are eliminated from the bloodstream the body can then

eliminate these minerals from tissue, too. This results in the

cessation of painful symptoms. Whether this works for other

conditions than Fibro, I don't know. I do know that the theory is

extremely controversial right now. I take guiafenesin to keep my

nasal and bronchial secretions from thickening up. So far, even

though I do take the medication at the suggested levels by the Dr.

who came up with this treatment plan, I notice no improvement in my

condition. I do not think that there is any evidence it helps

anyone with a spondyloarthropathy disease. For more information do

a search using the following terms:

Fibromyalgia, calcium, guiafenesin

You should come up with many articles related to a Dr. Armand's

research and other's reactions to it.

Ray

[Guest guest]

Connie,

I am asthmatic and have chronic ear and sinus problems. I have been taking

Guaifenesin since 1991. I don't believe it has helped my muscles, aches,

etc.; however, it has been a God-send with respect to helping to keep my

ears from retaining fluid and keeping my lungs clear. I take it in pill

form that is a combination of pseudoephedrine and guaifenesin. Brand names

vary. Two that I remember are Pan Mist LA and Duratuss. I believe the tabs

are 80 mg. of pseudoephedrine and 800 mgs. of guaifenesin. I take them

twice a day, morning and evening. I also use Meclizine 25 mg. for my

inner-ear problem (vertigo).

Regards!

[Guest guest]

Connie & : I haven't tried the stuff you are mentioning, but my dr put

me on beconase AQ (beclomethasone dipropionate, monohydrate) nasal spray

0.042% two times a day (not habit forming) and it has done a WORLD of good

for the sinus headaches. Just my two cents worth. Kathy from WI

[Guest guest]

Yes, Maarit.

But if you use a decongestant with it and reduce acidity, it works much

quicker, much simpler and can relieve all symptoms.

I have the medical records to prove it.

Please read:

http://www.fibrofix.com

Basically, what I do is:

1. Wear eye mask and ear plugs to get deep restorative sleep every night.

2. NO soft drinks because they have lots of phosphoric acid. Very acidic.

NO tomatoes - in any form. Very acidic.

NO lemons - in any form. Very acidic.

3. C H E W calcium tablets to neutralize Hyaluronic Acid. HA is a good

thing, it's the clear, natural lubricant and conditioner that is supposed

to be circulating through our entire bodies. But in Fibro folks it's a

little too thick, and we have too much of it.

4. Take prescription decongestant to open the body up to normal.

Take prescription Guaifenesin (expectorant) to help get the

excess, neutralized acid (which is very much like mucous) out of the body.

I have been on this newly-devised, prescription-based treatment for 36 months

(since October, 2000) and remain free of all symptoms.

These are the only meds of any kind that I take.

This is not a cure or remission. I have to take the meds every day. But, I

was disabled before and am fine now.

As far as we can learn, this is the first time anyone had every gotten total

relief from all symptoms of Severe Fibromyalgia using a prescription-based

treatment.

All info and details are free to the public on the web site. I answer all

emails and phone calls personally.

We accept no donations and charge nothing. We pay the web site, email and

phone costs out of our own pockets.

The only reason we have the web site is to try to help those who still suffer.

Please help us get the word out.

Anne Hillebrand

Orlando, FL

1st of 5,000,000 by the unlimited grace of my almighty God.

[Guest guest]

You'd have to read the whole thing to find this, so here's the quick version.

We knew all along that acid was a problem in my situation.

I read Buskilla's research article on the tests his group did on Fibro

patients in Tel Aviv. Had seen a reference to it on Devin Starlanyl's web

site.

First time I had heard of HA. A similar study says his was all bunk.

But, the first time I had taken the Entex LA (Guai + decongestant) in rather

large quantity, it literally felt like Jello was melting and flowing out my

limbs to my fingers and toes. My toe joints crackled and popped for several

days. Felt like " Pop Rocks " candy sounds.

Had been reading more about HA, and realized that must be what was missing.

Before I was given Celebrex and this Fibro went full blown, I had gone to the

doctor for my back. My lower back didn't hurt, it just wouldn't work. Like

a dry door hinge.

For years, the discs in my back had been bulged. My right knee had not

worked since 1981 (knee surgery gone very wrong).

My female system had not worked in 25 years.

When we started on the Entex LA, everything started working.

I read between about 200 to 700 research abstracts most months, many on

PubMed and similar sites.

Dr. Arthur O. , MD, Chief of Ethics, Clinical Pathology and Human

Trials, U.S. Army, Fort Deatrick, MD was a wonderful source of info on

Hyaluronic Acid.

You can read what he shared on http://www.fibrofix.com.

Currently am trying to figure out if the HA thickens up, as I have thought up

until now, or if it is actually the correct thickness, but is not being

broken down in some parts of the body where that is needed.

Hyaluronidase is a catalyst that is supposed to break down HA and increase it

permeability. Perhaps it is failing in some areas.

I spent 72 hours with almost no sleep the first part of last week just

reading and emailing and thinking about it.

Well, hope that helps. Welcome any info or comments you may have on HA or

any aspect of this.

We know what causes the symptoms and how to beat them.

We want to know what causes the syndrome itself.

Look forward to hearing from you.

Hope you will read the entire web site. It is amateur at best, but it's the

unvarnished truth the best we can tell it.

On the front page is a little red rectangle with an incredible, but true

story. The link says " Testimony - an amazing story " . I really hope you will

take time to read it.

Sincerely,

Anne Hillebrand

Orlando, FL

Medical Maverick

Intellectual Wild Card and

Rogue Grandmother

1st of 5,000,000 by the unlimited grace of my almighty God.

--

Can't go to sleep or back to sleep?

Tired, stiff, in terrible pain?

Can't think clearly? Weight gain?

Acid reflux? Tingling? Fatigue?

Read about Fibromyalgia and the

first ever completely effective

treatment. All info is free.

http://www.fibrofix.com

[Guest guest]

p.s.

- are you the lady who called from California? Your company had just

finished first trials on a test for Hyaluronic Acid in Fibro?

If so, I really need to talk to you guys.

There would not be excess HA in the extremities. It would be a deficiency.

There will be excess HA at and " upstream of " the tender points.

My phone is 407-925-4139.

Any time.

Anne Hillebrand

Orlando, FL

[Guest guest]

Thanks, . I'll have to dig back through some things to find that other

's email address.

You will want to check out the readings for pH. Below 6.0 or so is acidic.

pH of 7.5 would be on the alkali side. 4.0 would be very acidic.

I always remember " when the number is high, the acid is low " .

Looking forward to hearing from you.

You can beat this beast, kiddo. We have!

Annie

--

Can't go to sleep or back to sleep?

Tired, stiff, in terrible pain?

Can't think clearly? Weight gain?

Acid reflux? Tingling? Fatigue?

Read about Fibromyalgia and the

first ever completely effective

treatment. All info is free.

http://www.fibrofix.com

[Guest guest]

I use a real high-tech term - junk! ha ha.

Take care

Annie

--

Can't go to sleep or back to sleep?

Tired, stiff, in terrible pain?

Can't think clearly? Weight gain?

Acid reflux? Tingling? Fatigue?

Read about Fibromyalgia and the

first ever completely effective

treatment. All info is free.

http://www.fibrofix.com

[Guest guest]

Hi Annie,

Just for the sake of accuracy, I don't think the statement in your sig

that your protocol is " the first ever completely effective treatment "

for fibromyalgia is necessarily true, so it may be worth clarifying.

Thanks,

Luke

[Guest guest]

Hi, . I usually answer questions on personal email, but if no one

minds, I'm glad to do it here.

You wrote:

Anne, I have read over your website and here are my questions:

a. why is the decongestant necessary ?

If you don't open the body up to normal, the neutralized acid cannot get out.

At least that's the best I can understand of how it works.

b. is this treatment different from Dr. St. Amands ?

Yes, quite a bit different.

I only avoid a few products and foods.

This treatment works very quickly.

There is no cycling, mapping or record keeping needed.

I don't have any symptoms, and don't take any pain pills. I understand that

those using the Guai Protocol may need pain relief until such time as they

get completely well.

The Guai Protocol was developed by a medical doctor who has 40 years of his

own experience with the illness. Last I heard he still had symptoms, though.

I am just an amateur who was desperate. But I am free of all symptoms.

Q: Are any of the patients following his protocol using a guai that contains a

decongestant?

I cannot speak for any of them, but have never heard of anyone doing that.

c. Are you still taking Entex LA with PPA or have you switched to the one

with phenylephrine ?

I have taken Entex LA with phenylephrine. We tested it when it first became

available from Andrex Labs. It worked just fine.

As it says on our Medications page, Entex LA with Guai + PPA is no longer

available.

I still take it, and have for the past 36 months, all but during that test

period. We want to keep me on the same thing for as long as possible.

I took Entex LA (Guai + PPA) for over 17 years for breathing problems

following a medical accident (knee surgery that lead to 30 days in the

hospital).

I have been taking it in the large quantities for the past 3 years. First as

Entex LA, and more recently, separately as Guai and PPA.

With 20 years of experience on it with no problems, it seems best to stay

with it. We know I haven't had any adverse reaction to it.

For a while I got it by buying up (with a prescription) the last of what was

available at pharmacies around the country.

Then, before the newer Entex LA became available and when there was no

substitute, a compounding pharmacist made it for me. He did it because he

knew I had to have it to live. He has since passed away and I miss him dearly.

I will continue to take Guai + PPA it as long as we can get it.

Now, it has to come from outside the country. I put it up in capsules myself.

Can I tell you how to get Guai outside the country? Yes. Will I tell you

how to get PPA? No.

Guai is available over the counter in the US now, although it is much more

expensive than it used to be.

PPA, however, was recalled by the FDA due to death by hemmoraghic stroke in

some users.

d. Is Entex LA with PPA different or better or worse than Entex LA

with phenylephrine ?

With the 20 years of experience on the original with no problems, it seems

best for me to stay with it.

But for everyone else who has Fibro, it makes more since to use what is

currently available.

It does the same thing, but using a different compound to do it.

e. I found a couple things on the Dr.Art page really interesting

" ..Glucuronic acid also participates in matrix formation. We called this

term ecm or extra cellular matrix. All cells sit on some form of ecm in the

body. This matrix is often a part of connective tissues of the body and

forms links between epithelial cells and collagen, or it may link collagen

fibers together. " " "

maybe this is a cause of " leaky gut "

I don't know the answer to that one, . When I first got treatment,

everything started working normally within just an hour or so. But the

Irritable Bowel Syndrome took a few days to clear up. It seemed that the

insides of my guts were just ragged and raw (from not having the natural

lubricant and conditioner on the walls) and had to heal.

and also

" Hyaluronic acid is also involved in the immune system and in inflammatory

processes.

A molecule code named CD-44 is found on certain kinds of inflammatory cells

and on activated lymphocytes. This CD-44 molecule specifically binds to

hyaluronic acid on the surfaces of endothelial cells, connective tissue

cells and endothelial cells. This interaction allows the activated lymphocyte

to complete its immune maturation without committing suicide. If hyaluronic

acid is missing, immune reactive cells that make antibodies cannot mature

properly and may die rather than continue dividing or maturing into antibody

forming cells. "

maybe this is why I can't beat candida

Dr. Art's comments have been a big help, and are of great interest, but

saying I understand everything he said would be a lie.

Candida is not something I have any experience with.

Thanks for your questions, . Hope the answers help.

Let me know if there is anything at all we can do to be of help to you.

Sincerely,

Anne Hillebrand

Orlando, FL

1st of 5,000,000 by the unlimited grace of my almighty God.

annehillebrand@...

http://www.fibrofix.com

Ann,

I have read over your website and here are my questions:

a. why is the decongestant necessary ?

b. is this treatment different from Dr. St. Amands ? ie. Are any

of the patients following his protocol using a guai that contains a

decongestant ?

c. Are you still taking Entex LA with PPA or have you switched to

the one with phenylephrine ?

d. Is Entex LA with PPA different or better or worse than Entex LA

with phenylephrine ?

e. I found a couple things on the Dr.Art page really interesting

" ..Glucuronic acid

also participates in matrix formation. We called this term

ecm or extra cellular

matrix. All cells sit on some form of ecm in the body. This

matrix is often a part of

connective tissues of the body and forms links between

epithelial cells and

collagen, or it may link collagen fibers together. " " "

- maybe this is a cause of " leaky gut "

and also

. " Hyaluronic acid is also involved in the immune system and in

inflammatory processes.

A molecule code named CD-44 is found on certain kinds of

inflammatory cells and

on activated lymphocytes. This CD-44 molecule specifically

binds to hyaluronic

acid on the surfaces of endothelial cells, connective tissue

cells and endothelial

cells. This interaction allows the activated lymphocyte

to complete its immune

maturation without committing suicide. If hyaluronic acid is

missing, immune

reactive cells that make antibodies cannot mature properly and

may die rather than c

continue dividing or maturing into antibody forming cells. "

- maybe this is why I can't beat candida

Thanks,

[Guest guest]

As far as we can learn, Luke, this was the first time that any treatment

has completely relieved all symtoms of Fibromyalgia and kept working.

We have heard of people who have gone into remission. For some reason their

symptoms stopped and they did not have to use any treatment after that for at

least an extended period of time.

I also will not dispute anyone who says they were miraculously healed. That

is between them and God - not for me to question.

Other reports we have had all seem to be from someone who still have some

symptoms (stiffness, has to take pain pills, use massage, etc). Or they are

from folks who are selling something.

Do you know of anyone who has beaten all symptoms and is willing to give out

their doctor's name and address?

If so, is what they are doing something others can do, too?

Thanks for the question. If we see that the statement is misleading, I'll

change it in a flash.

Anne H

[Guest guest]

Hi Anne,

> As far as we can learn, Luke, this was the first time that any treatment

> has completely relieved all symptoms of Fibromyalgia and kept working.

Yes, but others have made similar claims. There's many examples - Dr

Lowe's hypometabolic theory comes first to my mind for FM, plus theirs

Jim's FIR protocol and others as Ken mentions too (anticoagulants,

antiviral etc). I'm following Lowe's metabolic rehab protocol at the

moment for FM, as he has both published studies

(http://www.drlowe.com/articles/blinded.htm) and an enormous amount of

research in " The Metabolic Treatment of Fibromyalgia "

(http://www.mcdowellpublishing.com/contnts.htm) behind him. Who knows

if it will work though. My point is just that most reasonable

protocols seem to work for some people, some of the time, and that

while yours may be a another worthwhile protocol, its just not the first.

I don't dispute your own or others experiences on your protocol, nor

do I have a problem with you letting people know about it if you

really think it works, I just think with so much misinformation and

hearsay out there we need to be accurate as possible when making

statements about these syndromes and their various treatments.

All the best,

Luke

[Guest guest]

You wrote:

Hi Anne,

> As far as we can learn, Luke, this was the first time that any treatment

> has completely relieved all symptoms of Fibromyalgia and kept working.

Yes, but others have made similar claims.

**** I've seen the claims. Lots of claims. Where are the people who have

gotten complete relief? I provide name, address and phone number.

There's many examples - Dr Lowe's hypometabolic theory comes first to my mind

for FM, plus theirs Jim's FIR protocol and others as Ken mentions too

(anticoagulants, antiviral etc). I'm following Lowe's metabolic rehab

protocol at the moment for FM, as he has both published studies

(http://www.drlowe.com/articles/blinded.htm) and an enormous amount of

research in " The Metabolic Treatment of Fibromyalgia "

http://www.mcdowellpublishing.com/contnts.htm) behind him. Who knows

if it will work though. My point is just that most reasonable

protocols seem to work for some people, some of the time, and that

while yours may be a another worthwhile protocol, its just not the first.

***** Am not familiar with this one. I'll read about it.

How are you doing on the treatment?

I don't dispute your own or others experiences on your protocol, nor

do I have a problem with you letting people know about it if you

really think it works, I just think with so much misinformation and

hearsay out there we need to be accurate as possible when making

statements about these syndromes and their various treatments.

***** Hearsay is when you don't have first hand proof. I'm walking around

proof.

I offer to let any reseacher run any tests they need to. With me on the

meds, then off, for comparison. Or blood tests, etc. Anything they need to

further the understanding of this treatment or our illness.

It only takes a few hours off the meds before the symptoms show up full blown

again, then only about 15 mintutes back on them for complete relief again.

Sincerely,

Anne Hillebrand

Orlando, FL

[Guest guest]

Luke, Dr Lowe is a chiropractor.

He is also selling a book.

On his web site it says his article is in " Medical Hypotheses " , and says it

is a prestigeous publication.

It is not subject to peer review, and those who put articles in it pay a

" page charge " .

Anne

[Guest guest]

> Luke, Dr Lowe is a chiropractor.

You mean he has a degree in chiropractic? He does. He also has a BA

and MA in psychology too (http://www.drlowe.com/jcl/biojcl.htm). His

hobbies include philosophy of science and symbolic logic. Does this

have much to do with the research and writing he has done over the

past couple of decades? You tell me!

However I can't help but note the extreme irony in your statement -

" oh, he's a chiro, so he probably has a kooky, unscientific, dogmatic

understanding of health and really isn't worth listening to at all,

much less trusted with my health " . Anne, nothing could be further from

the truth - Lowe is more dedicated to the cold, hard, brutal

scientific truth than anyone I've read, even if it means proving his

own hypothesis wrong!

Anne, I don't understand why you would want to discredit Dr Lowe? Lowe

is to FM what Cheney is to CFS (or Goldstein, or whoever). I put it to

you that *no one* has done more for our understanding of fibromyalgia

than Lowe & co has. Lowe is by far the must underrated researcher in

the field today, imo. If only people would *read* his work...

> He is also selling a book.

I hardly see this as a conflict of interest! Especially when its the

product of several years of full time work; probably the most

important document on FM written to date; and quite literally " a

scientific treatise of the highest calibre. "

Anne, if you really want those with FM to recover, why would you cast

aspersions on the leading researcher, author and clinician in the

field???

Live and let live I say...

Luke... Dr Lowe fanboy #1 ;P

[Guest guest]

.

A decongestant is a vaso-restrictor.

It makes swollen vessels and membranes shrink back to normal size so that the

normal pathways in between are not squeezed closed.

Anne

--

Can't go to sleep or back to sleep?

Tired, stiff, in terrible pain?

Can't think clearly? Weight gain?

Acid reflux? Tingling? Fatigue?

Read about Fibromyalgia and the

first ever completely effective

treatment. All info is free.

http://www.fibrofix.com

[Guest guest]

The Guaifenesin is an expectorant. It helps transport the mucus out of the

body.

You may want to think of it like this:

If you had oil on your garage floor -

you could just sweep it around and around.

You might could eliminate it eventually.

But, if you opened the garage door (decongestant),

put down some cat litter (Calcium)

then used a broom to sweep it out (expectorant),

you could get it out quickly and easily.

Not the best example, but I just got off work and my

brain is on other things.

Esentially - the treatment I am using has 5 parts and does 4 things:

Eye mask and ear plugs block out ALL light and sound -

fibro folk perceive light and sound as being much more important

than they are. Even a little light or sound is enough to keep us

from getting deep, restorative sleep.

Calcium - neutralizes the excess, thickened Hyaluronic Acid.

Hyaluronic Acid is a good thing - it's the natural lubricant

and conditioner in every cell of our bodies.

In fibro folk it is a little too thick. It can't circulate to reach

all the places it needs to. And it can't get out of the body correctly

via perspiration, discharge of vaginal lubrication, out the gut, etc.

Decongestant - Phenylephrine is the best one available as far as we know.

Opens the bodies pathways up to normal status.

Expectorant - Guaifenesin. Helps to get the neutralized HA on out of the

body.

No soft drinks or other highly acid foods. They just contribute to overall

body acidity, which we do not need.

Stomach acid and Hyaluronic Acid are not the same thing and I believe that

they do not mix in the body.

Write again if this doesn't answer your questions.

Like I said, you can start with the non-meds " tricks " and see if you get

relief just from that.

Keep in touch and let us know if we can help in any way.

Anne H

--

Can't go to sleep or back to sleep?

Tired, stiff, in terrible pain?

Can't think clearly? Weight gain?

Acid reflux? Tingling? Fatigue?

Read about Fibromyalgia and the

first ever completely effective

treatment. All info is free.

http://www.fibrofix.com

[Guest guest]

> The Guaifenesin is an expectorant. It helps transport the mucus

out of the

> body.

>

Actually, when I went to the Dr. Amand lecture-conference about 5

years ago, he said the Guafenesin removes excess Calcium phosphates

from the body or kidney.

If you read the new NCF research at www.ncf-net.org under newsletter

link, you will also read that there is the mention of a calcium

influx that I thought could be related, but am not sure.

Al

[Guest guest]

To Al and all.

From what I am able to tell, Dr. St. Amand and his Guai users still have

symptoms - most have serious symptoms.

I don't.

Haven't had in 3 years.

The decongestant, reducing acid intake, and neutralizing Hyaluronic Acid

are major differences in these two treatments.

The only thing they have in common is Guaifenesin.

Sometime go to the Guai Support message board and read how those people are

actually doing.

What symptoms they have, whether or not they are able to work, golf, etc.

Their stories will break your heart. Many of them say their spouses have

left, they can't work, don't have insurance, can't get around, can't think,

etc.

Then stop to think. My husband and I have been married 32 years.

He's using the last couple of days of his annual vacation. I'm taking off to

enjoy it with him.

We have been chasing our Jack Terrior though the house together.

Being romantic. Laughing. Doing projects around the house.

Tomorrow we'll probably detail our two vehicles out on the driveway. Both 4-

door Explorers. I may start doing the drywall top coat on our back bathroom.

Tomorrow afternoon and evening I'm going to bake cookies and stuff with the

women's circle at the Winter Garden First United Methodist Church.

Without the treatment I am using, I was disabled in horrible pain and so

brain fogged I could not take care of myself most of the time.

As soon as I started using it, I got my life back. Then, with a little fine-

tuning, I started to feel and think like 35 instead of 50 years old.

I owe Dr. St Amand a great debt simply because we read only a small portion

of his web site. It mentioned Guaifenesin.

From there on out, it was a totally different ball game.

Please read http://www.fibrofix.com

There's nothing for sale. It's a public service. Tells exactly what I am

doing and taking.

The only reason we keep the web site and write about this is to help YOU.

We don't want fame or money, or we would write a book and charge the sox off

of everyone.

There is no reason you can't do the same thing I'm doing and have the same

results, unless you have other health issues that won't permit it.

I can't imagine why you wouldn't want to try at least the " tricks " .

Anne Hillebrand

Orlando, FL

1st of 5,000,000 by the unlimited grace of my almighty God.

--

Can't go to sleep or back to sleep?

Tired, stiff, in terrible pain?

Can't think clearly? Weight gain?

Acid reflux? Tingling? Fatigue?

Read about Fibromyalgia and the

first ever completely effective

treatment. All info is free.

http://www.fibrofix.com

[Guest guest]

> Expectorant - Guaifenesin. Helps to get the neutralized HA on out

of the

> body.

There is no evidence that guaifenesin reduces acid content in the

body. On the contrary. The body metabolizes guaifenesin into

beta-(2-methoxyphenoxy) lactic acid. In other words, guaifenesin

actually introduces an acid into the body! How do you think it has a

uricosuric ability to begin with? In order to compete with uric acid,

you need another similar acid. The reason why salicylate acid

supposedly blocks guaifenesin, is again because it's competing with an

acid. So you take 1000mg of guaifenesin, you get tons of the

metabolite, that gets excreted. It's no wonder that people see a

difference in their urine, all that extra acid from the guaifenesin.

You want a reason why people start to feel bad if they take too much

guaifenesin, you don't need a cycling theory for that. You just have

to look at the tons of this lactic acid which is being introduced into

the body.

Studies have shown that guaifenesin has very little thinning effect on

mucus itself. Instead, it appears that it's able to to open mucus

pores, which thus causes mucus to flow more easily. In fact, this is

likely to cause more mucus to be created. This effect is quite

possibly linked to it's neurological ability to reduce neuron

activity, which would relax muscles and open passage ways in the body.

Many natural decongestants also have muscle relaxing ability (i.e.

kava kava and peppermint oil). This neurological ability is most

likely the reason why some people with fibromyalgia find it reduces

their pain. In fact, other people are recognizing this ability, and

are putting guaifenesin into transdermal pain patches which applied to

aching areas of the body. Another researcher has discovered that this

ability then increase the pain relieve effects of analgesic like tylenol.

Besides which, hyaluronic acid is actually being promoted as a remedy

to help fibromyalgia! See:

http://www.google.com/search?hl=en & lr= & ie=ISO-8859-1 & safe=off & q=hyaluronic+acid+\

fibromyalgisure

In any event, people taking the time released version of guaifenesin

probably are seeing very little uricosuric effect. The only study

that looked at this effect, used large doses of non-time released

versions, and deemed it's effect not substantial enough to make it

useful as a uricosuric drug. So it's no wonder that the

study on guaifenesin didn't show an uricosuric effect for the time

released version. When you are on time released, only a small amount

of the guaifenesin metabolite appears at the kidneys at any one time.

For more information about guaifenesin, and links to the studies that

I mention, see:

http://web.mit.edu/london/www/guai.html

[Guest guest]

Dear " Whoopandado " ,

Thank you for your post and the link to your document. It looks very

comprehensive and I've printed it out to digest over a few days.

Have you an recomendations for things that do work?

With kindest regards,

Annette

(in London)

[Guest guest]

> aching areas of the body. Another researcher has discovered that this

> ability then increase the pain relieve effects of analgesic like

tylenol.

>

Hm, I didn't get the grammar correct here. It should have read " this

ability increases the pain relieving effects of analgesics, like

tylenol " . Basically, some propanediol drugs like guaifenesin have

neurological effects, and some researchers hypothesize that this is

due to an antagonistic effect on excitatory amino acids. These amino

acids excites neuron receptors like NMDA, which causes pain. Other

drugs used for fibromyalgia also have a similar effect on NMDA

neurons. So in effect, guaifenesin is not really doing anything so

different, than other drugs for fibromyalgia. It's just that people

like Amand started using guaifenesin without realizing it had this

effect. All he knew was that it was a uricosuric, albeit a weak one.

However, it worked better than stronger uricosuric, which should have

set off bells, that perhaps another effect was actually the cause, but

he didn't bother to fully investigate the drug.

Mark

[Guest guest]

> Dear " Whoopandado " ,

>

> Thank you for your post and the link to your document. It looks very

> comprehensive and I've printed it out to digest over a few days.

>

> Have you an recomendations for things that do work?

Note that I didn't say guaifenesin doesn't work, I just explain it

differently. IMHO, fibromyalgia, like any disease, has to be treated

holistically, which means identifying all the possible secondary

health conditions which you may have, i.e. treating nurtritional

deficiencies, immune system problems, hormonal imbalances, etc. I.e.

magnesium deficiency, lyme disease, hypothyroidism. And making sure

you don't have other problems like celiac, sjogren's, RSD, Chornic

Myofascial Pain, osteoarthritis, etc. Changing your diet to avoid any

allergens, ingredients like aspartate and MSG (and possibly

salicylates!), trying a low carb diet, etc. But especially treating

any sleep disorder, finding meds that will help you sleep through the

night, trying meds like neurontin, especially if you have burning

pain, possibly trying SSRIs like Effexor, etc. etc.

Actually, the real recommendation would be to locate a doctor that

could help you do all the above!

[Guest guest]

I know I've seen guaifenesin discussed in this group.

for those who take it, how much do you take?

Sandy

Beaumont, CA

MCTD, scleroderma prevailing