collagen and arthritis- websites

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Hi Everyone,

I saw the inquiries about collagen and arthritis and remembered the studies

that Trentham has done. He is an AP doc in Boston that many of you

know.

http://www.hyperimmuneegg.org/studies/StudyTrentham.htm

Passive Transfer by Cells of Type II Collagen-Induced Arthritis in Rats

E. Trentham, Roselynn A. Dynesius, and R. Department of

Medicine, Harvard Medical School and B. Brigham Hospital, Boston,

Massachusetts 02115

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Abstract

To investigate the role of immunologic hypersensitivity to collagen in the

causation of type II collagen-induced arthritis in rats, passive transfer

experiments were performed. Wistar/ rats used in these experiments were

demonstrated to be histocompatible by prolonged skin graft survival and

mixed lymphocyte cultures. Popliteal lymph node weight assays excluded a

potential for graft-vs.-host reactivity in this strain. 9 of 32 naive rats

developed arthritis after intravenous receipt of pooled spleen and lymph

node cells from donors that had been injected intradermally with type II

collagen emulsified in incomplete Freund's adjuvant. This passively

transferred synovitis was evident clinically as well as histologically. In

control cell transfer experiments involving a total of 97 recipients,

transfer of arthritis was shown to require viable cells sensitized to type

II collagen. These controls included 17 rats receiving cells from

unimmunized donors, 20 recipients of cells from donors injected with

incomplete Freund's adjuvant alone, and 24 recipients of cells from rats

injected with type I collagen in adjuvant. Deliberate addition of

solubilized type II collagen to unsensitized cells at the time of transfer

or injection of heat-killed sensitized cells also did not cause arthritis in

a total of 36 recipients. These latter two control groups indicate that

disease transfer was not the result of antigen carry-over. Intravenous

injection of sera from arthritic donors was incapable of passively

transferring clinical or histologic synovitis in 30 recipients. Thus, these

studies directly implicate immunologic sensitivity to the cartilage type of

collagen in the etiology of this autoimmune disease.

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Selected References

These references are in PubMed. This may not be the complete list of

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