Guest guest Posted April 14, 2010 Report Share Posted April 14, 2010 has anyone been tested for antibodies to intrinsic factor? anyone know anything about intrinsic factor? s Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2010 Report Share Posted April 14, 2010 Just know it is a protein in the stomach that immune system attacks in pernicious anemia which prevents absorption of b12 > > has anyone been tested for antibodies to intrinsic factor? anyone know anything about intrinsic factor? s > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2010 Report Share Posted April 14, 2010 Just know it is a protein in the stomach that immune system attacks in pernicious anemia which prevents absorption of b12 > > has anyone been tested for antibodies to intrinsic factor? anyone know anything about intrinsic factor? s > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2010 Report Share Posted April 14, 2010 Just know it is a protein in the stomach that immune system attacks in pernicious anemia which prevents absorption of b12 > > has anyone been tested for antibodies to intrinsic factor? anyone know anything about intrinsic factor? s > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 15, 2010 Report Share Posted April 15, 2010 Hi Suzanne, Yep it's a test for PA. You need BOTH Parietal Cell Abs and Intrinsic Factor Abs tested for thatplus testing for Intrinsic Factor too I think. For complete status need B12, RBC Folate, urinary MMA, Homocysteine, CBC with differential. Theres a few PA forums around plus theres a B12 & Ferritin forum on RTH. (many folks are doing B12 injections there). RTH Ferritin & B12 subforum http://forums.realthyroidhelp.com/viewforum.php?f=4 .......................................................... From their sticky... Intrinsic Factor Antibody and Parietal Cell Antibody Tests Once a low B12 deficiency is diagnosed some further testing may be required. Pernicious Anaemia ( PA) is characterized by low B12 , and a high MCV (mean corpuscular volume) of the red blood cells. One blood test that may be ordered is for Intrinsic Factor Antibody and Parietal Cell Antibody. Both are done by a simple blood draw. However, diagnosing PA from the results is anything but simple. The Australian Society of Clinical Immunology and Allergy Inc. published " Consensus Guidelines on Anti-Intrinsic Factor Antibody Testing " in 2004. They reported: If both parietal cell antibody and intrinsic factor antibody are positive- Immunological evidence of Pernicious Anemia If parietal cell antibody is positive but intrinsic factor antibody is negative- Gastric Parietal cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). In 20-30% of patients, relatives of patients with PA, autoimmune thyroiditis and a small percentage of healthy persons may be positive and run an increased long term risk of pernicious anemia. A negative Intrinsic Factor antibody result does not exclude the diagnosis of PA as only 60% of patients with PA will have this antibody. If parietal cell antibody is positive and intrinsic factor antibody is not done- Gastric Parietal Cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). 20-30% of relatives of patients with PA, autoimmune thyroiditis and a small percentage of patients may be positive and never reach the stage of PA. If PA is suspected, we suggest testing for antibodies to intrinsic factor. ------------------------------------------ link to PA Forum.......... http://www.pernicious-anaemia-society.org/phpbb/index.php Lethal Lee > > has anyone been tested for antibodies to intrinsic factor? anyone know anything about intrinsic factor? s > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 15, 2010 Report Share Posted April 15, 2010 Hi Suzanne, Yep it's a test for PA. You need BOTH Parietal Cell Abs and Intrinsic Factor Abs tested for thatplus testing for Intrinsic Factor too I think. For complete status need B12, RBC Folate, urinary MMA, Homocysteine, CBC with differential. Theres a few PA forums around plus theres a B12 & Ferritin forum on RTH. (many folks are doing B12 injections there). RTH Ferritin & B12 subforum http://forums.realthyroidhelp.com/viewforum.php?f=4 .......................................................... From their sticky... Intrinsic Factor Antibody and Parietal Cell Antibody Tests Once a low B12 deficiency is diagnosed some further testing may be required. Pernicious Anaemia ( PA) is characterized by low B12 , and a high MCV (mean corpuscular volume) of the red blood cells. One blood test that may be ordered is for Intrinsic Factor Antibody and Parietal Cell Antibody. Both are done by a simple blood draw. However, diagnosing PA from the results is anything but simple. The Australian Society of Clinical Immunology and Allergy Inc. published " Consensus Guidelines on Anti-Intrinsic Factor Antibody Testing " in 2004. They reported: If both parietal cell antibody and intrinsic factor antibody are positive- Immunological evidence of Pernicious Anemia If parietal cell antibody is positive but intrinsic factor antibody is negative- Gastric Parietal cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). In 20-30% of patients, relatives of patients with PA, autoimmune thyroiditis and a small percentage of healthy persons may be positive and run an increased long term risk of pernicious anemia. A negative Intrinsic Factor antibody result does not exclude the diagnosis of PA as only 60% of patients with PA will have this antibody. If parietal cell antibody is positive and intrinsic factor antibody is not done- Gastric Parietal Cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). 20-30% of relatives of patients with PA, autoimmune thyroiditis and a small percentage of patients may be positive and never reach the stage of PA. If PA is suspected, we suggest testing for antibodies to intrinsic factor. ------------------------------------------ link to PA Forum.......... http://www.pernicious-anaemia-society.org/phpbb/index.php Lethal Lee > > has anyone been tested for antibodies to intrinsic factor? anyone know anything about intrinsic factor? s > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 15, 2010 Report Share Posted April 15, 2010 Hi Suzanne, Yep it's a test for PA. You need BOTH Parietal Cell Abs and Intrinsic Factor Abs tested for thatplus testing for Intrinsic Factor too I think. For complete status need B12, RBC Folate, urinary MMA, Homocysteine, CBC with differential. Theres a few PA forums around plus theres a B12 & Ferritin forum on RTH. (many folks are doing B12 injections there). RTH Ferritin & B12 subforum http://forums.realthyroidhelp.com/viewforum.php?f=4 .......................................................... From their sticky... Intrinsic Factor Antibody and Parietal Cell Antibody Tests Once a low B12 deficiency is diagnosed some further testing may be required. Pernicious Anaemia ( PA) is characterized by low B12 , and a high MCV (mean corpuscular volume) of the red blood cells. One blood test that may be ordered is for Intrinsic Factor Antibody and Parietal Cell Antibody. Both are done by a simple blood draw. However, diagnosing PA from the results is anything but simple. The Australian Society of Clinical Immunology and Allergy Inc. published " Consensus Guidelines on Anti-Intrinsic Factor Antibody Testing " in 2004. They reported: If both parietal cell antibody and intrinsic factor antibody are positive- Immunological evidence of Pernicious Anemia If parietal cell antibody is positive but intrinsic factor antibody is negative- Gastric Parietal cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). In 20-30% of patients, relatives of patients with PA, autoimmune thyroiditis and a small percentage of healthy persons may be positive and run an increased long term risk of pernicious anemia. A negative Intrinsic Factor antibody result does not exclude the diagnosis of PA as only 60% of patients with PA will have this antibody. If parietal cell antibody is positive and intrinsic factor antibody is not done- Gastric Parietal Cell antibody is associated with >90% of patients with Autoimmune Gastritis, the end result of which may be Pernicious Anemia (PA). 20-30% of relatives of patients with PA, autoimmune thyroiditis and a small percentage of patients may be positive and never reach the stage of PA. If PA is suspected, we suggest testing for antibodies to intrinsic factor. ------------------------------------------ link to PA Forum.......... http://www.pernicious-anaemia-society.org/phpbb/index.php Lethal Lee > > has anyone been tested for antibodies to intrinsic factor? anyone know anything about intrinsic factor? s > Quote Link to comment Share on other sites More sharing options...
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