Horrible reflux symptoms despite baking soda

[Guest guest]

,Do you mind if I share this post with another group? I think it might be beneficial to a mom looking for some answers.-Tammy To: mb12valtrex Sent: Friday, January 13, 2012 12:06 AM Subject: Re: Horrible reflux symptoms despite baking soda

is,

I don't know if you've gotten a chance to look at Frye and Dan Rossignol's excellent meta-analysis on melatonin in autism that was recently published, but they were constrained in reviewing what had been studied already and by what the authors knew about melatonin who did those studies. There was a lot these investigators didn't know.

Did you know that melatonin can help with reflux?

It is actually a big regulator and participant in intestinal physiology. Some melatonin is made in the pineal gland, but even more (unbelievably!) is made in the gut.

See http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240674/pdf/WJGPT-2-50.pdf and the other 18 articles on melatonin and GERD.

So, you might take a look at the studies, and see if you'd like to try melatonin, and see if that helps.

If, when you get your OAT, you would like me to do the dilution correction that becomes necessary when the kidneys start secreting creatinine (throwing the usual correction off) let me know. This correction can only be done on the full OAT, not the microbial OAT.

One of the evidences that this secretion of creatinine to urine in the tubule cells might be happening is that serum creatinine will go down at the same time, because creatinine is being removed from blood and added to urine. Years ago, when people made creatinine the standard for calculating dilution, they thought it just went through the filter, but didn't think it was secreted. That ended up incorrect.

Clin Cancer Res. 2012 Jan 5. [Epub ahead of print]

Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients.

Ciarimboli G, Lancaster CS, Schlatter E, e RM, Sprowl JA, Pavenstadt H, Massmann V, Guckel D, Mathijssen RH, Yang W, Pui CH, Relling MV, Herrmann E, Sparreboom A.

Source

Exp. Nephrologie, Universitätsklinikum Münster.

Abstract

PURPOSE:

Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients receiving chemotherapeutic agents.

EXPERIMENTAL DESIGN:

Creatinine transport was studied in transfected HEK293 cells in vitro and in wildtype mice and age-matched organic cation transporter 1 and 2-deficient [Oct1/2(-/-)] mice ex vivo and in vivo. Clinical pharmacogenetic and transport inhibition studies were done in two separate cohorts of cancer patients.

RESULTS:

Compared to wildtype mice, creatinine clearance was significantly impaired in Oct1/2(-/-) mice. Furthermore, creatinine inhibited organic cation transport in freshly-isolated proximal tubules from wild-type mice and humans, but not in those from Oct1/2(-/-) mice. In a genetic-association analysis (n=590), several polymorphisms around the OCT2/SLC22A2 gene locus, including rs2504954 (P=0.000873), were significantly associated with age-adjusted creatinine levels. Furthermore, in cancer patients (n=68), the OCT2 substrate cisplatin caused an acute elevation of serum creatinine (P=0.0083), consistent with inhibition of an elimination pathway.

CONCLUSIONS:

Collectively, this study shows that OCT2 plays a decisive role in the renal secretion of creatinine. This process can be inhibited by OCT2 substrates, which impair the usefulness of creatinine as a marker of renal function.

PMID:

22223530

>

> Caryn, it was based on his symptoms and clinical history. I'm eagerly waiting for alinia to come back in the market as that was our first choice. I'm trying to get his OAT test done.

> is

>

[Guest guest]

Hi is,

If you don't mind my asking, what signs of adrenarche are you seeing in him?

Cathy

>

I think my son is going through the same hormonal imbalance as we see signs of

adrenarche in him. His initial workup was negative for adrenal hyperplasia but

he has a follow up coming soon.

[Guest guest]

,

My son is on 3 mg of melatonin which he takes every night. I looked for the

article by Dan Rossignol but couldn't find it so far but will keep looking. I

did read the one that you sent the link for. Once I have the OATs test result, I

will forward it to you. Thanks

is

> >

> > Caryn, it was based on his symptoms and clinical history. I'm eagerly

waiting for alinia to come back in the market as that was our first choice. I'm

trying to get his OAT test done.

> > is

> >

>

[Guest guest]

Hi Cathy,

My son started having a lot of body odour this year. Also developed two thick

hair in his armpit. Earlier this year he had a growth spurt and when we did the

blood work, his testosterone was found to be high but his androstanedione(which

indicates congenital adrenal hyperplasia) was normal. He has some bumps on his

nose. His hair growth all over the body has increased. When we found out that

his testosterone is elevated, I did some digging and found that too much zinc

replacement will lead to elevated testosterone. Body builders love to take zinc

for the purpose. My son was on 50 mg then. He was also taking l-carnitine then

which potentiates the action of testosterone. So I stopped zinc and repeated the

testosterone level in a couple weeks and the repeat level was normal. He did not

have any further hair growth but still has body odour. His testes are

prepubertal so it doesn't look like precocious puberty. It could be adrenarche

based on some hair growth, bumps on his nose, and body odour but we will not

know for sure till we get the followup done next month. We will have the

hormonal reevaluation and see what it shows. We have a feeling that my son was

growing very fast last year but now his growth has slowed. His bone maturation

was also ten years when he was not even 8 yet. If he does have mild congenital

hyperplasia, that would mean that in times of stress, he doesn't make enough

cortisol and makes other hormones on the pathway instead because of deficiency

of one of the enzymes. Let me know if you have any other questions as I can

provide more detail on adrenal hyperplasia.

is

> >

> I think my son is going through the same hormonal imbalance as we see signs of

adrenarche in him. His initial workup was negative for adrenal hyperplasia but

he has a follow up coming soon.

>

[Guest guest]

anna God and I had that same deal as well!!! my son is no longer carries his label, best of luck on your journey!

From:

Sent: Thursday, January 12, 2012 11:11 PM

To: mb12valtrex

Subject: Re: Re: Horrible reflux symptoms despite baking soda

Hi is,

You're very welcome. Happy to share any time. It's a deal I made with God. Show me the way and I will spread the word. Only in this case the word is not religion. The word is what I learn, what works for us, and to promote kinder, gentler more ethical treatment of kids.

Hope you find some relief from your health issues.

Hi ,I have been reading about holy basil and really want to try it. But I personally have an enzyme deficiency which actually leads to low cortisol in stressful situations. Holy basil may actually help but I am not sure of my current hormonal status. I had the workup done several years ago and never did the follow up. You have motivated me to get myself checked out and once I figure out what my hormonal status is, I would love to try holy basil. I think my son is going through the same hormonal imbalance as we see signs of adrenarche in him. His initial workup was negative for adrenal hyperplasia but he has a follow up coming soon. I will let you know if holy basil is an option for us. Thank you so much for the detailed response regarding the parasite treatments. is> > >> > > Hi is,> > >> > > I suggested the Holy Basil. It is an adaptogen, which means it> > > balances. Most of our kids have high anxiety and high stress levels,> > > which usually means high cortisol levels. I believe I mentioned that> > > it helped with high cortisol levels, but because it is an > > adaptogen I> > > don't think you need to worry if your son's levels are high or > > low. It> > > also balances the GI tract. My son used to have horrible reflux too,> > > often bringing back up small amounts of what he had eaten with each> > > burp. He used to be in so much pain. I should also mention that the> > > reflux improved a little after we got rid of the tapeworm he had,> > > which was before we started using the Holy Basil.> > >> > > We use New Chapters Holy Basil. Their line is organic. I cannot > > speak> > > for the other brands.> > >> > > I spent 20 years battling chest pains and burping secondary to > > reflux.> > > It was horrible, it hurt so much and I could barely breathe. I > > used to> > > take ibuprofen to manage the pain. Then I tried the Holy Basil > > (since> > > I had some for my son and was giving it to him to treat his > > cortisol)> > > and found it worked great for the reflux. Now I only take it when I> > > have eaten really fatty foods that set me off. But I even have a> > > better tolerance for that kind of food too and don't need to take it> > > very often at all.> > >> > > Hope this helps.> > >> > > > > >> > >> > >> > > > Hi everyone,> > > > My son is dealing with chest pain and burps which improved with> > > > baking powder temporarily but now came back. Activated charcoal > > also> > > > helps with it but now that seems insufficient. Our dan has> > > > recommended pepcid but I don't wanna use it if I can find > > something> > > > safer. My son used zantac for the first year of his life but it > > used> > > > to make him sleepy and tired all the time. When we stopped zantac> > > > around his first birthday, he was less tired and more active. It > > may> > > > not be related but I am too scared to cause any regression in him.> > > > Has anyone tried homeopathy for acid reflux? Someone had suggested> > > > holy basil but that decreases cortisol and I am not sure if my > > son's> > > > cortisol levels are high enough to tolerate that. How many of you> > > > are using zantac or pepcid for their kids? Have you noticed any> > > > negatives from using those like changes in behaviors or speech? I> > > > have another thought that since my son started swallowing > > capsules,> > > > he started having this type of pain. Could it be because he is not> > > > swallowing capsules right and they are causing erosions or it is> > > > true reflux? We are in NJ and was wondering if someone could> > > > recommend a good Gastroenterologist who has some compassion for > > our> > > > kids?> > > > Thanks> > > > is> > > >> > > >> > >> >> >>

[Guest guest]

I have heard that the kindest most knowledgable gastro is Dr Buie at Mass

General Hospital. There is probably a massive waiting list but worth an inquiry.

>

> Hi everyone,

> My son is dealing with chest pain and burps which improved with baking powder

temporarily but now came back. Activated charcoal also helps with it but now

that seems insufficient. Our dan has recommended pepcid but I don't wanna use it

if I can find something safer. My son used zantac for the first year of his life

but it used to make him sleepy and tired all the time. When we stopped zantac

around his first birthday, he was less tired and more active. It may not be

related but I am too scared to cause any regression in him. Has anyone tried

homeopathy for acid reflux? Someone had suggested holy basil but that decreases

cortisol and I am not sure if my son's cortisol levels are high enough to

tolerate that. How many of you are using zantac or pepcid for their kids? Have

you noticed any negatives from using those like changes in behaviors or speech?

I have another thought that since my son started swallowing capsules, he started

having this type of pain. Could it be because he is not swallowing capsules

right and they are causing erosions or it is true reflux? We are in NJ and was

wondering if someone could recommend a good Gastroenterologist who has some

compassion for our kids?

> Thanks

> is

>

[Guest guest]

Thank you Christel. Your e-mail gives me hope that one day I will be able to say the same. anna God and I had that same deal as well!!! my son is no longer carries his label, best of luck on your journey! From: Sent: Thursday, January 12, 2012 11:11 PM To: mb12valtrex Subject: Re: Re: Horrible reflux symptoms despite baking soda Hi is, You're very welcome. Happy to share any time. It's a deal I made with God. Show me the way and I will spread the word. Only in this case the word is not religion. The word is what I learn, what works for us, and to promote kinder, gentler more ethical treatment of kids. Hope you find some relief from your health issues. Hi ,I have been reading about holy basil and really want to try it. But I personally have an enzyme deficiency which actually leads to low cortisol in stressful situations. Holy basil may actually help but I am not sure of my current hormonal status. I had the workup done several years ago and never did the follow up. You have motivated me to get myself checked out and once I figure out what my hormonal status is, I would love to try holy basil. I think my son is going through the same hormonal imbalance as we see signs of adrenarche in him. His initial workup was negative for adrenal hyperplasia but he has a follow up coming soon. I will let you know if holy basil is an option for us. Thank you so much for the detailed response regarding the parasite treatments. is> > >> > > Hi is,> > >> > > I suggested the Holy Basil. It is an adaptogen, which means it> > > balances. Most of our kids have high anxiety and high stress levels,> > > which usually means high cortisol levels. I believe I mentioned that> > > it helped with high cortisol levels, but because it is an > > adaptogen I> > > don't think you need to worry if your son's levels are high or > > low. It> > > also balances the GI tract. My son used to have horrible reflux too,> > > often bringing back up small amounts of what he had eaten with each> > > burp. He used to be in so much pain. I should also mention that the> > > reflux improved a little after we got rid of the tapeworm he had,> > > which was before we started using the Holy Basil.> > >> > > We use New Chapters Holy Basil. Their line is organic. I cannot > > speak> > > for the other brands.> > >> > > I spent 20 years battling chest pains and burping secondary to > > reflux.> > > It was horrible, it hurt so much and I could barely breathe. I > > used to> > > take ibuprofen to manage the pain. Then I tried the Holy Basil > > (since> > > I had some for my son and was giving it to him to treat his > > cortisol)> > > and found it worked great for the reflux. Now I only take it when I> > > have eaten really fatty foods that set me off. But I even have a> > > better tolerance for that kind of food too and don't need to take it> > > very often at all.> > >> > > Hope this helps.> > >> > > > > >> > >> > >> > > > Hi everyone,> > > > My son is dealing with chest pain and burps which improved with> > > > baking powder temporarily but now came back. Activated charcoal > > also> > > > helps with it but now that seems insufficient. Our dan has> > > > recommended pepcid but I don't wanna use it if I can find > > something> > > > safer. My son used zantac for the first year of his life but it > > used> > > > to make him sleepy and tired all the time. When we stopped zantac> > > > around his first birthday, he was less tired and more active. It > > may> > > > not be related but I am too scared to cause any regression in him.> > > > Has anyone tried homeopathy for acid reflux? Someone had suggested> > > > holy basil but that decreases cortisol and I am not sure if my > > son's> > > > cortisol levels are high enough to tolerate that. How many of you> > > > are using zantac or pepcid for their kids? Have you noticed any> > > > negatives from using those like changes in behaviors or speech? I> > > > have another thought that since my son started swallowing > > capsules,> > > > he started having this type of pain. Could it be because he is not> > > > swallowing capsules right and they are causing erosions or it is> > > > true reflux? We are in NJ and was wondering if someone could> > > > recommend a good Gastroenterologist who has some compassion for > > our> > > > kids?> > > > Thanks> > > > is> > > >> > > >> > >> >> >>