Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

[Guest guest]

I can't remember if this was posted or if we talked about this. An evolving story in mainstream science, but what warrior parents and integrative practitioners have been saying for years. Even still, I find it vaguely reassuring. -SylviaProc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. Epub 2011 Aug 29.Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF.SourceLaboratory of NeuroGastroenterology, Alimentary Pharmabiotic Centre, School of Pharmacy, and Departments of Psychiatry and Anatomy, University College Cork, Cork, Ireland.AbstractThere is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice. In addition, L. rhamnosus (JB-1) reduced GABA(Aα2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aα2) in the hippocampus. Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior. Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Together, these findings highlight the important role of bacteria in the bidirectional communication of the gut-brain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.PMID: 21876150 [PubMed - in process]

[Guest guest]

l. rahmnosus aka culturelle that stuff is awesome..speaking of which just found out target is selling on sale for about ten bucks.

regulating GABA receptors always a good thing:)

channa

To: mb12valtrex Sent: Monday, September 26, 2011 10:18 PMSubject: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

I can't remember if this was posted or if we talked about this. An evolving story in mainstream science, but what warrior parents and integrative practitioners have been saying for years. Even still, I find it vaguely reassuring.

-Sylvia

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. Epub 2011 Aug 29.

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.

Bravo JA, Forsythe P, Chew MV, Escaravage

E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF.

Source

Laboratory of NeuroGastroenterology, Alimentary Pharmabiotic Centre, School of Pharmacy, and Departments of Psychiatry and Anatomy, University College Cork, Cork, Ireland.

Abstract

There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice. In

addition, L. rhamnosus (JB-1) reduced GABA(Aα2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aα2) in the hippocampus. Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior. Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Together, these findings highlight the important role of bacteria in the bidirectional communication of the gut-brain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.

PMID:

21876150

[PubMed - in process]

[Guest guest]

Channa,I thought Culturelle is

Lactobacillus GG not L. rhamnosus. It's clear it's been very helpful to you. But I just want to make sure I'm not missing anything. Thanks,Sylvia

l. rahmnosus aka culturelle that stuff is awesome..speaking of which just found out target is selling on sale for about ten bucks.

regulating GABA receptors always a good thing:)

channa

To: mb12valtrex Sent: Monday, September 26, 2011 10:18 PMSubject: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

I can't remember if this was posted or if we talked about this. An evolving story in mainstream science, but what warrior parents and integrative practitioners have been saying for years. Even still, I find it vaguely reassuring.

-Sylvia

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. Epub 2011 Aug 29.

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.

Bravo JA, Forsythe P, Chew MV, Escaravage

E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF.

Source

Laboratory of NeuroGastroenterology, Alimentary Pharmabiotic Centre, School of Pharmacy, and Departments of Psychiatry and Anatomy, University College Cork, Cork, Ireland.

Abstract

There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice. In

addition, L. rhamnosus (JB-1) reduced GABA(Aα2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aα2) in the hippocampus. Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior. Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Together, these findings highlight the important role of bacteria in the bidirectional communication of the gut-brain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.

PMID:

21876150

[PubMed - in process]

[Guest guest]

I remember reading they were the same thing. i could be wrong thou..

channa

To: mb12valtrex Sent: Wednesday, September 28, 2011 5:12 PMSubject: Re: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

Channa,

I thought Culturelle is Lactobacillus GG not L. rhamnosus. It's clear it's been very helpful to you. But I just want to make sure I'm not missing anything.

Thanks,

Sylvia

l. rahmnosus aka culturelle that stuff is awesome..speaking of which just found out target is selling on sale for about ten bucks.

regulating GABA receptors always a good thing:)

channa

To: mb12valtrex Sent: Monday, September 26, 2011 10:18 PMSubject: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

I can't remember if this was posted or if we talked about this. An evolving story in mainstream science, but what warrior parents and integrative practitioners have been saying for years. Even still, I find it vaguely reassuring.

-Sylvia

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. Epub 2011 Aug 29.

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.

Bravo JA, Forsythe P, Chew MV, Escaravage

E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF.

Source

Laboratory of NeuroGastroenterology, Alimentary Pharmabiotic Centre, School of Pharmacy, and Departments of Psychiatry and Anatomy, University College Cork, Cork, Ireland.

Abstract

There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice. In

addition, L. rhamnosus (JB-1) reduced GABA(Aα2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aα2) in the hippocampus. Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior. Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Together, these findings highlight the important role of bacteria in the bidirectional communication of the gut-brain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.

PMID: 21876150 [PubMed - in process]

[Guest guest]

I think Natures Way probiotics for kids (in the refrigerated section) contain rhamnosusTo: "mb12valtrex " <mb12valtrex >Sent: Wednesday, September 28, 2011 5:31 PMSubject: Re: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

I remember reading they were the same thing. i could be wrong thou..

channa

To: mb12valtrex Sent: Wednesday, September 28, 2011 5:12 PMSubject: Re: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

Channa,

I thought Culturelle is Lactobacillus GG not L. rhamnosus. It's clear it's been very helpful to you. But I just want to make sure I'm not missing anything.

Thanks,

Sylvia

l. rahmnosus aka culturelle that stuff is awesome..speaking of which just found out target is selling on sale for about ten bucks.

regulating GABA receptors always a good thing:)

channa

To: mb12valtrex Sent: Monday, September 26, 2011 10:18 PMSubject: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

I can't remember if this was posted or if we talked about this. An evolving story in mainstream science, but what warrior parents and integrative practitioners have been saying for years. Even still, I find it vaguely reassuring.

-Sylvia

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. Epub 2011 Aug 29.

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.

Bravo JA, Forsythe P, Chew MV, Escaravage

E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF.

Source

Laboratory of NeuroGastroenterology, Alimentary Pharmabiotic Centre, School of Pharmacy, and Departments of Psychiatry and Anatomy, University College Cork, Cork, Ireland.

Abstract

There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice. In

addition, L. rhamnosus (JB-1) reduced GABA(Aα2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aα2) in the hippocampus. Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior. Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Together, these findings highlight the important role of bacteria in the bidirectional communication of the gut-brain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.

PMID: 21876150 [PubMed - in process]

[Guest guest]

You're right. Lactobacillus GG is L. rhamnosus. Thanks,Sylvia

I remember reading they were the same thing. i could be wrong thou..

channa

To: mb12valtrex Sent: Wednesday, September 28, 2011 5:12 PMSubject: Re: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

Channa,

I thought Culturelle is Lactobacillus GG not L. rhamnosus. It's clear it's been very helpful to you. But I just want to make sure I'm not missing anything.

Thanks,

Sylvia

l. rahmnosus aka culturelle that stuff is awesome..speaking of which just found out target is selling on sale for about ten bucks.

regulating GABA receptors always a good thing:)

channa

To: mb12valtrex Sent: Monday, September 26, 2011 10:18 PMSubject: Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression

I can't remember if this was posted or if we talked about this. An evolving story in mainstream science, but what warrior parents and integrative practitioners have been saying for years. Even still, I find it vaguely reassuring.

-Sylvia

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. Epub 2011 Aug 29.

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.

Bravo JA, Forsythe P, Chew MV, Escaravage

E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF.

Source

Laboratory of NeuroGastroenterology, Alimentary Pharmabiotic Centre, School of Pharmacy, and Departments of Psychiatry and Anatomy, University College Cork, Cork, Ireland.

Abstract

There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice. In

addition, L. rhamnosus (JB-1) reduced GABA(Aα2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aα2) in the hippocampus. Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior. Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. Together, these findings highlight the important role of bacteria in the bidirectional communication of the gut-brain axis and suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.

PMID: 21876150 [PubMed - in process]

[Guest guest]

We use the Kirkmans Lacto Duo which contains more L. rhamnosus than what's contained in Culturelle -- but I dunno, Culturelle seems to be more effective than Lacto Duo alone.  I find I need to use both.  I wonder if it's the prebiotic in Culturelle that makes it work better?