RE: botox - more

[Guest guest]

This was good information also -

nne

Botulinum toxin type A for

chronic pain and pelvic floor spasm in women: a randomized controlled trial.

Abbott

JA, Jarvis

SK, Lyons

SD, Thomson

A, Vancaille

TG.

University of New South Wales, Sydney Australia.

jason.abbott@...

OBJECTIVE: To estimate whether botulinum toxin type A is more

effective than placebo at reducing pain and pelvic floor pressure in women with

chronic pelvic pain and pelvic floor muscle spasm. METHODS: This study was a

double-blinded, randomized, placebo-controlled trial. All participants

presented with chronic pelvic pain of more than 2 years duration and evidence

of pelvic floor muscle spasm. Thirty women had 80 units of botulinum toxin type

A injected into the pelvic floor muscles, and 30 women received saline.

Dysmenorrhea, dyspareunia, dyschezia, and nonmenstrual pelvic pain were

assessed by visual analog scale (VAS) at baseline and then monthly for 6

months. Pelvic floor pressures were measured by vaginal manometry. RESULTS:

There was significant change from baseline in the botulinum toxin type A group

for dyspareunia (VAS score 66 versus 12; chi2 = 25.78, P < .001) and

nonmenstrual pelvic pain (VAS score 51 versus 22; chi2 = 16.98, P = .009). In

the placebo group only dyspareunia was significantly reduced from baseline (64

versus 27; chi2 = 2.98, P = .043). There was a significant reduction in pelvic

floor pressure (centimeters of H2O) in the botulinum toxin type A group from

baseline (49 versus 32; chi2 = 39.53, P < .001), with the placebo group also

having lower pelvic floor muscle pressures (44 versus 39; chi2 = 19.85, P =

..003). CONCLUSION: Objective reduction of pelvic floor spasm reduces some types

of pelvic pain. Botulinum toxin type A reduces pressure in the pelvic floor

muscles more than placebo. Botulinum toxin type A may be a useful agent in

women with pelvic floor muscle spasm and chronic pelvic pain who do not respond

to conservative physical therapy. Clinical Trial Registration: Australian

Clinical Trials Registry, http://www.actr.org.au/, ACTRN012605000515695 LEVEL OF

EVIDENCE: I.

PMID: 17012454 [PubMed - indexed for MEDLINE]

From:

VulvarDisorders [mailto:VulvarDisorders ] On

Behalf Of Carolyn52192@...

Sent: Tuesday, April 01, 2008 8:23 AM

To: VulvarDisorders ; happypelvis

Subject: botox

http://www.ncbi.nlm.nih.gov/sites/entrez?itool=abstractplus & db=pubmed & cmd=Retrieve & dopt=abstractplus & list_uids=15249744