Guest guest Posted April 1, 2008 Report Share Posted April 1, 2008 Here's another one. Dee~ =============================Obstet Gynecol. 2004 Nov;104(5 Pt 1):913-4.Botulinum toxin in the treatment of refractory vaginismus.Ghazizadeh S, Nikzad M.Department of Obstetrics and Gynecology, Tehran University of MedicalSciences, Vali-e Asr Reproductive Health Research Center, Tehran,Iran. shirin_ghazizadeh@...OBJECTIVE: To investigate the efficacy of botulinum toxin injection totreat women with moderate and severe vaginismus.METHODS: Twenty-four women referred to our clinic from February 2002to February 2004 (mean age 25 years; range 19-34 years) with third- tofourth-degree vaginismus were recruited for this study. These womenhad previous unsuccessful treatments. Botulinum toxin (150-400 mIU)was injected into the puborectalis muscles in 3 sites on each side ofthe vagina.RESULTS: Twenty-three patients (95.8%) had vaginal examinations 1 weekpostoperatively that showed little or no vaginismus, 18 (75%) achievedsatisfactory intercourse after the first injection, 4 (16.7%) had mildpain, 1 was cured after a second injection, 1 patient refused vaginalexamination and did not attempt to have coitus, and another had nocoitus as a result of her husband's secondary impotence. The womenwere followed up for a mean of 12.3 months (range 2-24 months), andthere were no cases of recurrence. CONCLUSION: In refractory cases of vaginismus when conventionaltherapies have failed, local injection of botulinum toxin can beconsidered.PMID: 15516379 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 2, 2008 Report Share Posted April 2, 2008 I like the pun! I apologize for hijacking this thread and steering it towards vulvodynia. But, my wife is considering giving Botox a shot as a treatment for vulvodynia and mild vaginismus. Is anybody overly concerned about the side effects reported for botox? I think I remember reading somewhere about pelvic injections leading to " inability to hold intestinal gas " , but I can't remember where I read it. Anybody remember the reference? Since my wife is a public speaker, she is quite worried about that symptom. For studies that I've read with my wife most recently, these both look very promising: " Botulinum toxin A for the management of vulvodynia. " Yoon H, Chung WS, Shim BS. " Botulinum toxin a for vulvodynia: a case report. " Gunter J, Brewer A, Tawfik O. Here's a couple papers that I couldn't read due to lack of University subscription to these journals (if anybody has a copy or knows how to get them for free, a private e-mail would be very welcome): The Glazer paper doesn't look very promising but it was only a pilot study of 2 patients: " Subjective and objective outcomes of botulinum toxin type A treatment in vestibulodynia: pilot data. " Brown CS, Glazer HI, Vogt V, Menkes D, Bachmann G. Similar to the above glazer study but much more positive results in: " Botulinum toxin type A for the treatment of provoked vestibulodynia: an open-label, pilot study. " Dykstra DD, Presthus J. Botulinum toxin for the treatment of genital pain syndromes. Romito S, Bottanelli M, Pellegrini M, Vicentini S, Rizzuto N, Bertolasi L. Roque > > > > HI White lotus... nice to see your name. > > > > I sure remember Dr. A. Gordon from our group. Haven't heard from > or about him in a long time! > > > > Here's an abstract (below) about botox on vaginismus so no idea if > that'd help or not but for what it's worth. > > > > Also here's a link about botox in general > > http://www.dermadoctor.com/pages/newsletter41.asp?WID=%7BBC6CE86F% > 2D8E05%2D11D5%2D9174%2D0002B330452B%7D > > > > Then if you want to get into the deeper techincal end and how it > works, try this link. > > http://bmj.bmjjournals.com/cgi/content/full/320/7228/161? > maxtoshow=&HITS=40&hits=40&RESULTFORMAT=&titleabstract=botulism&fullte > xt=botox&searchid=1031927669435_9265&stored_search=&FIRSTINDEX=0&resou > rcetype=1,2,3,4,10 > > (If that's split or broken just copy and paste it all) > > > > Hugs and good luck! > > Dee~ > > > > Obstet Gynecol. 2004 Nov;104(5 Pt 1):913-4. > > > > Botulinum toxin in the treatment of refractory vaginismus. > > > > Ghazizadeh S, Nikzad M. > > > > Department of Obstetrics and Gynecology, Tehran University of > Medical > > Sciences, Vali-e Asr Reproductive Health Research Center, Tehran, > > Iran. shirin_ghazizadeh@ > > > > OBJECTIVE: To investigate the efficacy of botulinum toxin injection > to > > treat women with moderate and severe vaginismus. > > > > METHODS: Twenty-four women referred to our clinic from February 2002 > > to February 2004 (mean age 25 years; range 19-34 years) with third- > to > > fourth-degree vaginismus were recruited for this study. These women > > had previous unsuccessful treatments. Botulinum toxin (150-400 mIU) > > was injected into the puborectalis muscles in 3 sites on each side > of > > the vagina. > > > > RESULTS: Twenty-three patients (95.8%) had vaginal examinations 1 > week > > postoperatively that showed little or no vaginismus, 18 (75%) > achieved > > satisfactory intercourse after the first injection, 4 (16.7%) had > mild > > pain, 1 was cured after a second injection, 1 patient refused > vaginal > > examination and did not attempt to have coitus, and another had no > > coitus as a result of her husband's secondary impotence. The women > > were followed up for a mean of 12.3 months (range 2-24 months), and > > there were no cases of recurrence. > > > > CONCLUSION: In refractory cases of vaginismus when conventional > > therapies have failed, local injection of botulinum toxin can be > > considered. > > > > PMID: 15516379 [PubMed - indexed for MEDLINE] > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 2, 2008 Report Share Posted April 2, 2008 I am afraid of BOTOX and I sure could use some on my smile lines LOLThere was a segment on the TODAY show or CBS this morning that talked about the possbility of BOTULISM Poisoning from Botox., BlueeberriPlanning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 2, 2008 Report Share Posted April 2, 2008 One of my friends is having the Botox treatment on April 16th and I am having it on May 1, so we’ll let you know. I will ask my pain management doctor if has heard of these side effects. nne From: VulvarDisorders [mailto:VulvarDisorders ] On Behalf Of spamfreeid Sent: Wednesday, April 02, 2008 12:58 PM To: VulvarDisorders Subject: Re: BOTOX & Vaginismus I like the pun! I apologize for hijacking this thread and steering it towards vulvodynia. But, my wife is considering giving Botox a shot as a treatment for vulvodynia and mild vaginismus. Is anybody overly concerned about the side effects reported for botox? I think I remember reading somewhere about pelvic injections leading to " inability to hold intestinal gas " , but I can't remember where I read it. Anybody remember the reference? Since my wife is a public speaker, she is quite worried about that symptom. For studies that I've read with my wife most recently, these both look very promising: " Botulinum toxin A for the management of vulvodynia. " Yoon H, Chung WS, Shim BS. " Botulinum toxin a for vulvodynia: a case report. " Gunter J, Brewer A, Tawfik O. Here's a couple papers that I couldn't read due to lack of University subscription to these journals (if anybody has a copy or knows how to get them for free, a private e-mail would be very welcome): The Glazer paper doesn't look very promising but it was only a pilot study of 2 patients: " Subjective and objective outcomes of botulinum toxin type A treatment in vestibulodynia: pilot data. " Brown CS, Glazer HI, Vogt V, Menkes D, Bachmann G. Similar to the above glazer study but much more positive results in: " Botulinum toxin type A for the treatment of provoked vestibulodynia: an open-label, pilot study. " Dykstra DD, Presthus J. Botulinum toxin for the treatment of genital pain syndromes. Romito S, Bottanelli M, Pellegrini M, Vicentini S, Rizzuto N, Bertolasi L. Roque > > > > HI White lotus... nice to see your name. > > > > I sure remember Dr. A. Gordon from our group. Haven't heard from > or about him in a long time! > > > > Here's an abstract (below) about botox on vaginismus so no idea if > that'd help or not but for what it's worth. > > > > Also here's a link about botox in general > > http://www.dermadoctor.com/pages/newsletter41.asp?WID=%7BBC6CE86F% > 2D8E05%2D11D5%2D9174%2D0002B330452B%7D > > > > Then if you want to get into the deeper techincal end and how it > works, try this link. > > http://bmj.bmjjournals.com/cgi/content/full/320/7228/161? > maxtoshow= & HITS=40 & hits=40 & RESULTFORMAT= & titleabstract=botulism & fullte > xt=botox & searchid=1031927669435_9265 & stored_search= & FIRSTINDEX=0 & resou > rcetype=1,2,3,4,10 > > (If that's split or broken just copy and paste it all) > > > > Hugs and good luck! > > Dee~ > > > > Obstet Gynecol. 2004 Nov;104(5 Pt 1):913-4. > > > > Botulinum toxin in the treatment of refractory vaginismus. > > > > Ghazizadeh S, Nikzad M. > > > > Department of Obstetrics and Gynecology, Tehran University of > Medical > > Sciences, Vali-e Asr Reproductive Health Research Center, Tehran, > > Iran. shirin_ghazizadeh@ > > > > OBJECTIVE: To investigate the efficacy of botulinum toxin injection > to > > treat women with moderate and severe vaginismus. > > > > METHODS: Twenty-four women referred to our clinic from February 2002 > > to February 2004 (mean age 25 years; range 19-34 years) with third- > to > > fourth-degree vaginismus were recruited for this study. These women > > had previous unsuccessful treatments. Botulinum toxin (150-400 mIU) > > was injected into the puborectalis muscles in 3 sites on each side > of > > the vagina. > > > > RESULTS: Twenty-three patients (95.8%) had vaginal examinations 1 > week > > postoperatively that showed little or no vaginismus, 18 (75%) > achieved > > satisfactory intercourse after the first injection, 4 (16.7%) had > mild > > pain, 1 was cured after a second injection, 1 patient refused > vaginal > > examination and did not attempt to have coitus, and another had no > > coitus as a result of her husband's secondary impotence. The women > > were followed up for a mean of 12.3 months (range 2-24 months), and > > there were no cases of recurrence. > > > > CONCLUSION: In refractory cases of vaginismus when conventional > > therapies have failed, local injection of botulinum toxin can be > > considered. > > > > PMID: 15516379 [PubMed - indexed for MEDLINE] > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 2, 2008 Report Share Posted April 2, 2008 I just heard a little except on TV tonight about brain poisoning from Botox. I think I need to look into this a little further. But if all these celebrities get it in their face (which is close to the brain), I wonder if it is different when it goes into the muscles of the butt. nne From: VulvarDisorders [mailto:VulvarDisorders ] On Behalf Of blueeberri@... Sent: Wednesday, April 02, 2008 7:59 PM To: VulvarDisorders Subject: Re: Re: BOTOX & Vaginismus I am afraid of BOTOX and I sure could use some on my smile lines LOL There was a segment on the TODAY show or CBS this morning that talked about the possbility of BOTULISM Poisoning from Botox., Blueeberri Planning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 3, 2008 Report Share Posted April 3, 2008 Well, I would think Priscilla Presley is a good warning of the danger from too much Botox. The Frozen Face of Doom. > > I am afraid of BOTOX and I sure could use some on my smile lines LOL > There was a segment on the TODAY show or CBS this morning that talked about > the possbility of BOTULISM Poisoning from Botox., > > Blueeberri > > > > **************Planning your summer road trip? Check out AOL Travel Guides. > (http://travel.aol.com/travel-guide/united-states?ncid=aoltrv00030000000016) > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 3, 2008 Report Share Posted April 3, 2008 It was my son who first told me what Botox is. I just copied this from a Yahoo Health article: " Botulinum toxin type A is a toxin produced by the bacteria that causes botulism. Botulinum toxin type A affects the nerves. When injected into a muscle, it produces a reduction in the activity of the muscle. " I don't think I want to be injecting " toxin " or anything produced by Botulism into my ANYTHING! That just seems nuts to me! SDak Marcia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 If the doctor could show me substantial reasons why botox would work, I would try it. Botulism risk or not! Today I have this throbbing pain in my rectum, I either get this or subtle burning pain in my vagina. I am anxious to go to the doctor and hopeully get an accurate diagnosis. I was curious whether anyone else get this type of pain? I don't have pain externally in the behind area, it all seems internal and more throbbing types of pain, or those strange sharp jabby pains, that fortunately come and go. (in the front and back) I just took 2 advil to see if that would make a difference, if not, I guess I will take 1/2 ativan tonite. Its bizarre, I can always predict a pain free day, the day following the half ativan, I am making these mental notes to share with Dr G when I see him- I am no longer on the elavil. The homeopathic stuff I took apparently hasn't helped this unfortunately. Its interesting I didn't walk in the last two days ( I normally walk atleast 4 miles a day) so I thought for sure I wouldn't get any pain- so Im ruling out the single cause as exercise. Thanks for your responses:) CPlanning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 thanks Shopper, thats very interesting. How/Why did your daughter go that route? How could they tell what was happening? Did she have a colonoscopy? CPlanning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 Shopper, did this also cure her vestibulitis? CPlanning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 thanks Kristy, Im convinced that I have pelvic floor hypertonicity. I think that botox might help me. I think thats why the ativan works so well! CPlanning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 Im sure I would have to be knocked out too, heck I fainted at the eye doctor lol! That last article I sent on botox told of examples when someone has Vest. pain where botox would not help, because my levator ani muscles are in spasm, I think I would be a good candidate. CPlanning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 I mostly lurk and delete, but I saw your post on the rectal pain. Did you ever go to a GI doctor? My daughter had that and vestibulitis. It was coming from ulcers in her rectum from Crohn's disease. She started treatment for Crohn's and is now cured. She also had horrible vaginal burning on her period. Just a thought. -------------- Original message -------------- From: Carolyn52192@... If the doctor could show me substantial reasons why botox would work, I would try it. Botulism risk or not! Today I have this throbbing pain in my rectum, I either get this or subtle burning pain in my vagina. I am anxious to go to the doctor and hopeully get an accurate diagnosis. I was curious whether anyone else get this type of pain? I don't have pain externally in the behind area, it all seems internal and more throbbing types of pain, or those strange sharp jabby pains, that fortunately come and go. (in the front and back) I just took 2 advil to see if that would make a difference, if not, I guess I will take 1/2 ativan tonite. Its bizarre, I can always predict a pain free day, the day following the half ativan, I am making these mental notes to share with Dr G when I see him- I am no longer on the elavil. The homeopathic stuff I took apparently hasn't helped this unfortunately. Its interesting I didn't walk in the last two days ( I normally walk atleast 4 miles a day) so I thought for sure I wouldn't get any pain- so Im ruling out the single cause as exercise. Thanks for your responses:) C Planning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 She was having constipation for several years starting when she was about 12. When she was about 14, the vaginal burning with her period started. She would come home from school to sit in the bathtub the burning was so bad. She also started getting nausea when she ate and cramping around her belly button which eventually turned into really bad pain on one side. Her pediatricians did not take this very seriously and told me kids get constipated. I took her to a GI doctor who convinced her she had a nervous stomach. She started sleeping with a heating pad on her stomach. I found another GI doctor who insisted on blood work, an upper GI with a small bowel follow through, a colonoscopy, endoscopy, dexa scan and ultrasound. I took her to my vulvar specialist who told me she had vestibulitis. The upper gi showed a blockage in her ileum (that was the pain in the side), the colooscopy showed the ulcers starting in her rectum up to her decending colon and inflammation throughout her entire small and large intestine. The dexa scan showed full blown osteoporsis (she was 15). Blood showed inflammation markers. The rectal tissue with the ulcers was affecting her vagina. As her Crohn's came under control and it took about a year and a half the vaginal problems went away......completely. She is now 18. The Crohn's is in remission, but she still has osteoporis. She was also anemic. If she had only had the ulcers and inflammation in her colon she would have been diagnosed with colitis, but because it was all over they consider it crohn's. Many women with crohn's have vaginal problems. Sherri -------------- Original message -------------- From: Carolyn52192@... thanks Shopper, thats very interesting. How/Why did your daughter go that route? How could they tell what was happening? Did she have a colonoscopy? C Planning your summer road trip? Check out AOL Travel Guides. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 Carol, When the Botox injections do work for some (it didn't for a friend of mine) it is does so by helping the muscles to relax. This same thought about the relaxation is why it is sometimes offered to treat children with Cerebral Palsy that have a problem with a tightened Achilles tendon if PT doesn't work and to try and avoid surgically releasing the tendon. Botox for this issue with the Achilles tendon was not available when I was a kid so had to have the surgery (and will need to again). Kristy ________________________________________________________________________________\ ____ You rock. That's why Blockbuster's offering you one month of Blockbuster Total Access, No Cost. http://tc.deals.yahoo.com/tc/blockbuster/text5.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 Carol, Dr. Goldstein should be able to tell you for sure if this is your problem. My friend who tried the Botox because of her pain issues (her pain threshold is very low) had to be knocked out to get it done. I don't know if other women who have had this done need to do something similar. Kristy ________________________________________________________________________________\ ____ You rock. That's why Blockbuster's offering you one month of Blockbuster Total Access, No Cost. http://tc.deals.yahoo.com/tc/blockbuster/text5.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 I had the botox done for vaginismus but in my situation it did not work because i could not get past the pain in my vestibule for it to help. it was very painful but i could tell it relaxed the muscle but since it was still too painful to get passed the entry, it did me no good. the only thing that helped was surgery for vestibulitis > > Carol, > > Dr. Goldstein should be able to tell you for sure if this is > your problem. > > My friend who tried the Botox because of her pain issues (her > pain threshold is very low) had to be knocked out to get it > done. > > I don't know if other women who have had this done need to do > something similar. > > Kristy > > > > > > > ________________________________________________________________________________\ ____ > You rock. That's why Blockbuster's offering you one month of Blockbuster Total Access, No Cost. > http://tc.deals.yahoo.com/tc/blockbuster/text5.com > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 4, 2008 Report Share Posted April 4, 2008 Botox is deadly if too much is injested, but like most things the location of the injection and the units injected are important in addition to what is injected. Most chemo drugs are also deadly, but when used with purpose can save a life rather than ending one. I wouldn't fear any vaginismus treatment before discussing the real, rather than perceived danger with a competent Dr. Roque PS-I'm don't mean to sound preachy or pick a fight, but as a microbiologist, I do know a little about botulism. Its a little upsetting when new technology is dismissed. Especially since that might be my job in the future! > > It was my son who first told me what Botox is. I just copied this from a > Yahoo Health article: > > " Botulinum toxin type A is a toxin produced by the bacteria that causes > botulism. Botulinum toxin type A affects the nerves. When injected into a > muscle, it produces a reduction in the activity of the muscle. " > > I don't think I want to be injecting " toxin " or anything produced by > Botulism into my ANYTHING! That just seems nuts to me! > > SDak Marcia > Quote Link to comment Share on other sites More sharing options...
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