Influence of URSO on mortality & malignancy in PBC

[Guest guest]

Hepatology. 2007 Aug 8; [Epub ahead of print]

Influence of ursodeoxycholic acid on the mortality and malignancy

associated with primary biliary cirrhosis: A population-based cohort

study.

University of Nottingham Medical School, Division of Epidemiology and

Public Health, Medical School, Queen's Medical Centre, Nottingham,

United Kingdom.

There is debate over the mortality and malignancy risk in people with

primary biliary cirrhosis (PBC) and whether this risk is reduced by

use of ursodeoxycholic acid. To investigate this issue, we identified

930 people with PBC and 9,202 control subjects from the General

Practice Research Database in the United Kingdom. We categorized

regular ursodeoxycholic acid as treatment with 6 or more prescriptions

and nonregular treatment as less than 6. We found a 2.7-fold increase

in mortality for the PBC cohort compared with the general population

[adjusted hazard ratio (HR), 2.69; 95% CI, 2.35-3.09]. In those having

regular ursodeoxycholic acid (43%), the mortality increase was

2.2-fold (HR, 2.19; 95% CI, 1.66-2.87) and in those not treated

2.7-fold (HR, 2.69; 95% CI, 2.18-3.33). This apparent reduction in

mortality was not explained by less severe disease in the

ursodeoxycholic acid-treated group. The increased risk of primary

liver cancer in ursodeoxycholic acid-treated patients was 3-fold (HR,

3.17; 95% CI, 0.64-15.62), in contrast to an 8-fold increase in those

not treated (HR, 7.77; 95% CI, 1.30-46.65). Conclusion: We found that

people with PBC had a 3-fold mortality increase when compared with the

general population, which was somewhat reduced by regular treatment

with ursodeoxycholic acid. However, the observed effect of

ursodeoxycholic acid was not statistically significant. (HEPATOLOGY

2007.).

PMID: 17685473 [PubMed - as supplied by publisher]

With love, Barb in Texas

[Guest guest]

Barb:

I have been following Ken's progress and I wanted to visit his CaringBridge site

but I can't remember the name. Can you help me out?

I had been especially interested since, I believe he found out about his PSC

around the same time I did and I think he is just a little younger than me. I

thought that I would watch his progress and see how great he did and therefore

not be so afraid of the transplant when the time came. His progress didn't go

nearly as well as any of us had hoped but I was saying prayers the entire time.

Thanks.

also in Texas

PSC '01

>>> 8/15/2007 10:11 AM >>>

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