What's the generic drug name for URSO?

[Guest guest]

I've been trying to figure out the generic name and the pharmacy I

called says Actigall is the generic for URSO. Is this true or is there

another name for generic URSO? Does Actigall work the same as URSO?

I did read some of the study link in regards to Actigall and URSO but

couldn't make much sense of it.

Thanks,

Jed

PSC 6/2007

[Guest guest]

As wrote in msg 92996, 4/25/07:

I hope this article will answer your questions:

_____________

from: http://www.pscpartners.org/NewsVol-1-6.pdf

Ursodiol Formulations

Ursodiol is the " generic " name for ursodeoxycholic acid (UDCA), a bile

acid commonly prescribed for the treatment of cholestatic liver

diseases, such as primary biliary cirrhosis (PBC) and primary

sclerosing cholangitis (PSC). In the U.S.A., ursodiol is available

under two trade names; Actigall (typically available as 300 mg gelatin

capsules with a pink cap and white body containing a white/yellowish

powder), and URSO (typically available as white 250 mg tablets) [uRSO

250]. {also URSO Forte - white 500 mg tablets from Axcan Pharma, and

ursodiol 300mg red and white capsules (generic for Actigall) from Teva

USA (the least expensive option).}

Actigall was developed by Novartis Pharmaceuticals Corporation

and is now marketed by Pharmaceuticals:

http://www.watsonpharm.com/

The Actigall capsules also contain as inactive ingredients: colloidal

silicon dioxide, ferric oxide, gelatin, magnesium stearate, starch

(corn), and titanium dioxide.

URSO is marketed by Axcan Pharma:

http://www.axcan.com/

Axcan Pharma has recently developed a 500 mg tablet marketed as URSO

Forte. The inactive ingredients of URSO are: microcrystalline

cellulose, povidone, sodium starch glycolate, magnesium stearate,

ethylcellulose, dibutyl sebacate, carnauba wax, hydroxypropyl

methylcellulose, PEG 3350, PEG 8000, cetyl alcohol, sodium lauryl

sulfate, and hydrogen peroxide.

According to Levy and Angulo (2004) " Milligram per milligram, the

bioavailability of Actigall preparation is about two-thirds that of the

URSO 250 tablet available in the United States " .

According to Axcan Pharma " URSO Forte and URSO 250 are the only

ursodiols approved by the Food and Drug Administration for the

treatment of patients with Primary Biliary Cirrhosis (PBC), a chronic

liver disease that slowly destroys the ducts that drain bile in the

liver. The recommended adult dosage for URSO Forte and URSO 250 in the

treatment of PBC is 13-15 mg/kg/day administered in two to four

divided doses with food. "

Ursodiol is currently not " indicated " for treatment of PSC in the U.S.A;

nevertheless, many doctors prescribe it for this condition, and at a

higher dose than in PBC (typically 20 - 30 mg/kg/day for PSC) because

preliminary results suggest that it improves liver biochemistry in PSC

patients, and it may also offer protection against the development of

colon cancer and cholangiocarcinoma (see p. 2 of this issue).

In Australia, ursodiol is available as Ursofalk (Dr Falk Pharma GmbH)

as white, opaque, hard gelatin capsules. Each Ursofalk capsule contains

250 mg of ursodeoxycholic acid. These capsules also contain maize

starch, silicon dioxide, magnesium stearate, gelatin and titanium

dioxide as inactive ingredients. A liquid formulation of Ursofalk has

recently been developed for pediatric patients (Setchell et al., 2005).

References

Levy C, Angulo P (2004) Ursodeoxycholic acid and long-term survival

in primary biliary cirrhosis. Am. J. Gastroenterol. 99: 269-270.

Setchell KD, Galzigna L, O'connell N, Brunetti G, Tauschel HD

(2005) Bioequivalence of a new liquid formulation of ursodeoxycholic

acid (Ursofalk suspension) and Ursofalk capsules measured by plasma

pharmacokinetics and biliary enrichment. Aliment. Pharmacol. Ther.

21: 709-721.

Ursodiol ( Gastroenterology Patient Education)

http://www.gicare.com/pated/ursodiol.htm

Ursofalk (Ursodeoxycholic Acid)

http://www.orphan.com.au/Ursofalk_cmi00.htm

>

> I've been trying to figure out the generic name and the pharmacy I

> called says Actigall is the generic for URSO. Is this true or is there

> another name for generic URSO? Does Actigall work the same as URSO?

>

> I did read some of the study link in regards to Actigall and URSO but

> couldn't make much sense of it.

>

> Thanks,

>

> Jed

> PSC 6/2007

>

[Guest guest]

if someone is having trouble paying for any of there drugs..look up the company that makes the drugs...alot of them do have help for people that cant afford them it is alot of paper work but it is worth it..also Montel is a spokesmen for a program that helps people get there drugs..i cant remember the name of it but I'm sure somebody knows it..and nobody please be ashamed asking for help at first i was cause i have never done that before...and trust me there is help out there... none of us have done thing to get this disease but i dont have the attitude you owe me i am just so grateful for the help.... JeanneTim Romlein wrote: As wrote in msg 92996, 4/25/07:I hope this article will answer your questions:_____________from: http://www.pscpartners.org/NewsVol-1-6.pdfUrsodiol FormulationsUrsodiol is the "generic" name for ursodeoxycholic acid (UDCA), a bileacid commonly prescribed for the treatment of cholestatic liverdiseases, such as primary biliary cirrhosis (PBC) and primarysclerosing cholangitis (PSC). In the U.S.A., ursodiol is availableunder two trade names; Actigall (typically available as 300 mg gelatincapsules with a pink cap and white body containing a white/yellowishpowder), and URSO (typically

available as white 250 mg tablets) [uRSO250]. {also URSO Forte - white 500 mg tablets from Axcan Pharma, andursodiol 300mg red and white capsules (generic for Actigall) from TevaUSA (the least expensive option).}Actigall was developed by Novartis Pharmaceuticals Corporationand is now marketed by Pharmaceuticals:http://www.watsonpharm.com/The Actigall capsules also contain as inactive ingredients: colloidalsilicon dioxide, ferric oxide, gelatin, magnesium stearate, starch(corn), and titanium dioxide.URSO is marketed by Axcan Pharma:http://www.axcan.com/Axcan Pharma has recently developed a 500 mg tablet marketed as URSOForte. The inactive ingredients of URSO are: microcrystallinecellulose, povidone, sodium starch glycolate, magnesium stearate,ethylcellulose, dibutyl sebacate, carnauba wax,

hydroxypropylmethylcellulose, PEG 3350, PEG 8000, cetyl alcohol, sodium laurylsulfate, and hydrogen peroxide.According to Levy and Angulo (2004) "Milligram per milligram, thebioavailability of Actigall preparation is about two-thirds that of theURSO 250 tablet available in the United States".According to Axcan Pharma "URSO Forte and URSO 250 are the onlyursodiols approved by the Food and Drug Administration for thetreatment of patients with Primary Biliary Cirrhosis (PBC), a chronicliver disease that slowly destroys the ducts that drain bile in theliver. The recommended adult dosage for URSO Forte and URSO 250 in thetreatment of PBC is 13-15 mg/kg/day administered in two to fourdivided doses with food."Ursodiol is currently not "indicated" for treatment of PSC in the U.S.A;nevertheless, many doctors prescribe it for this condition, and at ahigher dose than in PBC (typically 20 - 30 mg/kg/day for PSC)

becausepreliminary results suggest that it improves liver biochemistry in PSCpatients, and it may also offer protection against the development ofcolon cancer and cholangiocarcinoma (see p. 2 of this issue).In Australia, ursodiol is available as Ursofalk (Dr Falk Pharma GmbH)as white, opaque, hard gelatin capsules. Each Ursofalk capsule contains250 mg of ursodeoxycholic acid. These capsules also contain maizestarch, silicon dioxide, magnesium stearate, gelatin and titaniumdioxide as inactive ingredients. A liquid formulation of Ursofalk hasrecently been developed for pediatric patients (Setchell et al., 2005).ReferencesLevy C, Angulo P (2004) Ursodeoxycholic acid and long-term survivalin primary biliary cirrhosis. Am. J. Gastroenterol. 99: 269-270.Setchell KD, Galzigna L, O'connell N, Brunetti G, Tauschel HD(2005) Bioequivalence of a new liquid formulation of ursodeoxycholicacid (Ursofalk

suspension) and Ursofalk capsules measured by plasmapharmacokinetics and biliary enrichment. Aliment. Pharmacol. Ther.21: 709-721.Ursodiol ( Gastroenterology Patient Education)http://www.gicare.com/pated/ursodiol.htmUrsofalk (Ursodeoxycholic Acid)http://www.orphan.com.au/Ursofalk_cmi00.htm--- In , "Jed" wrote:>> I've been trying to figure out the generic name and the pharmacy I > called says Actigall is the generic for URSO. Is this true or is there > another name for generic URSO? Does Actigall work the same as URSO?> > I did read some of the study link in regards to Actigall and URSO but > couldn't make much sense of it.

> > Thanks,> > Jed > PSC 6/2007>