Discontinuation of LDLT for PSC

[Guest guest]

Discontinuation of Living Donor Liver Transplantation for PSC Due to

Histological Abnormalities in Intraoperative Donor Liver Biopsy

Source: American Journal of Transplantation, September 2007

Abstract:

Liver transplantation is the only curative treatment known to date for

end-stage liver disease occurring as a result of primary sclerosing

cholangitis (PSC). Here, we report a case in which living donor liver

transplantation (LDLT) for PSC was cancelled because of histological

abnormalities in intraoperative biopsy of the donor liver. The donor

was the mother of the recipient, and her preoperative evaluation

revealed no abnormalities. In the donor operation, the donor liver

biopsy revealed expansion of the portal zone with lymphocytic

infiltration and dense concentric fibrosis developed around a bile

duct. These histological findings were identical to those of

early-stage PSC; therefore, the LDLT was called off. The experience in

this case suggests that preoperative liver biopsy may be useful to

exclude first-degree relative donors with potential PSC prior to LDLT

for PSC.

[Guest guest]

Well that would have been a heart breaking situation. Thanks for

sharign this. It's a good idea!

from NE

psc dx 8/07

>

> Discontinuation of Living Donor Liver Transplantation for PSC Due

to

> Histological Abnormalities in Intraoperative Donor Liver Biopsy

>

> Source: American Journal of Transplantation, September 2007

>

These histological findings were identical to those of

> early-stage PSC; therefore, the LDLT was called off. The experience

in

> this case suggests that preoperative liver biopsy may be useful to

> exclude first-degree relative donors with potential PSC prior to

LDLT

> for PSC.

>