Depression in patients with PBC and PSC.

[Guest guest]

J Hepatol. 2007 Jun;46(6):1099-103.

Depression in patients with PBC and PSC.

van Os E, van den Broek WW, Mulder PG, ter Borg PC, Bruijn JA, van Buuren HR.

Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.

BACKGROUND/AIMS: Former studies reported a high prevalence of

depression in patients with primary biliary cirrhosis (PBC) and

primary sclerosing cholangitis (PSC). These studies hypothesized that

the presence of depression could explain the fatigue experienced by

these patients.

METHODS: Our aim was to study the prevalence of depression in a Dutch

population with PBC and PSC. In addition, to investigating the effects

of using an additional diagnostic structured psychiatric interview,

after screening with the Beck Depression Inventory (BDI), a

self-report severity scale instrument used in former studies. Patients

with PBC and PSC (n=92) completed the BDI. Patients with scores of 10

or higher (n=39) were interviewed using a structured psychiatric

interview. Patients with scores lower than 10 were at random (30/53,

57%) also interviewed using a structured psychiatric interview.

RESULTS: Of the 92 patients that were included 42% had depressive

symptoms according to the BDI. However, of these patients only 3.7%

had a depressive syndrome according to the DSM-IV criteria as assessed

with the structured psychiatric interview.

CONCLUSIONS: The prevalence of a depressive disorder in patients with

PBC and PSC is not higher than in the general population. Fatigue in

patients with PBC and PSC cannot be explained by depression.

PMID: 17399846 [PubMed - indexed for MEDLINE]

[Guest guest]

Barb,

Thanks for that info. My fatigue is back in a big way. My sister's first

comment was that I should try an antidepressant. I don't think I'm

depressed, even though this fatigue coming back is depressing and

frustrating. It may lead to depression.

CONCLUSIONS: The prevalence of a depressive disorder in patients with

PBC and PSC is not higher than in the general population. Fatigue in

patients with PBC and PSC cannot be explained by depression.

-Marie

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[Guest guest]

Marie, I totally agree about fatigue causing depression and not the

other way around. I have been battling a bad case of depression

lately, and I feel like it is mainly the result of the daily fatigue

I feel. I get so frustrated with the fatigue, it just won't let go.

- PSC, 2000; UC, 1991

Original Post:

Thanks for that info. My fatigue is back in a big way. My sister's

first

comment was that I should try an antidepressant. I don't think I'm

depressed, even though this fatigue coming back is depressing and

frustrating. It may lead to depression.

CONCLUSIONS: The prevalence of a depressive disorder in patients with

PBC and PSC is not higher than in the general population. Fatigue in

patients with PBC and PSC cannot be explained by depression.

-Marie

[Guest guest]

Hi All,

Is it possible to have fatigue but also be able to rife a bike to

work, 12 miles round trip? I don't feel depressed per se, but just

extremely amotivated all the time. It seemed to start some time

during the last 2 years since my diagnosis.

Any thoughts?

Washington, DC

>

> Marie, I totally agree about fatigue causing depression and not the

> other way around. I have been battling a bad case of depression

> lately, and I feel like it is mainly the result of the daily

fatigue

> I feel. I get so frustrated with the fatigue, it just won't let

go.

>

> - PSC, 2000; UC, 1991

>

>

> Original Post:

> Thanks for that info. My fatigue is back in a big way. My sister's

> first

> comment was that I should try an antidepressant. I don't think I'm

> depressed, even though this fatigue coming back is depressing and

> frustrating. It may lead to depression.

>

> CONCLUSIONS: The prevalence of a depressive disorder in patients

with

> PBC and PSC is not higher than in the general population. Fatigue

in

> patients with PBC and PSC cannot be explained by depression.

>

> -Marie

>

[Guest guest]

I would say yes. There are times I can do things and

it simply amazes me, but then there are other things

that I can't do, and also, things I refuse to do

because life is too short and my priorities have

changed.

I somehow make it to work each day.

Cindy Baudoux-Northrup

________________________________________________________________________________\

____

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[Guest guest]

, I would definately say yes. You can have the fatigue feeling

but still have plenty of energy. I've come to believe that the

fatigue that most PSC and PBC patients are familiar with, is

something a little different in nature than what most people think of

when they hear the word 'fatigue'. It's not the same as fatigue you

would get from say, lack of sleep or a vitamin deficiency, but it

best describes the feeling, so it is commonly used. I've heard it

better described as cement or lead in your veins. To me personally

it feels like that whole-body ache you get when fighting the flu.

Take care.

>

> Hi All,

>

> Is it possible to have fatigue but also be able to rife a bike to

> work, 12 miles round trip? I don't feel depressed per se, but just

> extremely amotivated all the time. It seemed to start some time

> during the last 2 years since my diagnosis.

>

> Any thoughts?

>

>

> Washington, DC