PSC recurrence

[Guest guest]

Is there a gender bias in recurrence after transplantation? I can

think of many men who have reported being diagnosed with PSCr

(including myself), but no women (Arne, please correct me if I am just

showing signs of early senility and can't remember reported instances

of PSCr in women).

On another note, " The recurrence rate [as a cause of graft failure for

PSC] increased from 22.2 to 27.4%, " between two successive 5-year

periods (period I=1992–1996 vs period II=1997–2002) according to the

paper, " No Improvement in Long-Term Liver Transplant Graft Survival in

the Last Decade: An Analysis of the UNOS Data " by Y. Futagawaa, P. I.

Terasakia, & #8727;, K. Wakia, J. Caia and D. W. Gjertsonb

http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1600-6143.2006.01256.x?cookie\

Set=1

They report that change wasn't statically significant.

Tim R

[Guest guest]

Hi Tim;

According to Dr. J. Neuberger, the recurrence risk for PSC after

liver transplant is only slightly higher in men than in women. The

greatest risk seems to be having an intact colon:

Lancet. 2002 Dec 14;360(9349):1943-4.

Risk factors for recurrence of primary sclerosing cholangitis of

liver allograft.

Vera A, Moledina S, Gunson B, Hubscher S, Mirza D, Olliff S,

Neuberger J

Liver Unit, Queen Hospital, B15 2TH, Birmingham, UK.

Primary sclerosing cholangitis (PSC) is a disease of unknown cause

that effects the biliary tree and is closely associated with

inflammatory bowel disease. We did a retrospective analysis of the

risk factors associated with recurrence of PSC in an allograft after

liver transplantation. Recurrence of disease, assessed by liver

histology or imaging the biliary tree, occurred in 56 of 152 patients

(37%) at a median of 36 months (range 1.4-120 months). Multivariate

analysis showed that being male (relative risk 1.2, 95% CI 0.73-2.15)

and an intact colon before transplantation (8.7, 1.19-64.48) were

associated with recurrence. These observations could help elucidate

the pathogenesis of the disease. PMID: 12493264.

Best regards,

Dave

(father of (22); PSC 07/03; UC 08/03)

>

> Is there a gender bias in recurrence after transplantation?