Re: PSC & Excema

[Guest guest]

Hi Alison;

I havn't come across a direct link between PSC and eczema, but there

may be one with Crohn's disease:

Scand J Gastroenterol. 2004 Aug;39(8):731-6.

Atopic manifestations are more common in patients with Crohn disease

than in the general population.

Myrelid P, Dufmats M, Lilja I, Grinn C, Lannerstad O, Sjödahl R

Dept. of Surgery, Unit of Colorectal Surgery, University Hospital,

Linkoping, Sweden. par.myrelid@...

BACKGROUND: The role of TNF-alpha in Crohn disease is now well

established and anti-TNF-alpha is frequently used as a second- or

third-line treatment. Tumor necrosis factor-alpha (TNF-alpha) is

traditionally associated with macrophages but has recently also been

found in mast cells of the ileal wall in patients with Crohn disease.

As it is well known that mast cells and TNF-alpha play important

roles in atopic manifestations like asthma, allergic rhinitis; and

eczema the aim of this study was to investigate whether these are

seen more commonly in Crohn patients than in the general population.

METHODS: Patients with Crohn disease (n = 308), aged 18-50 years,

living in the Linköping region in southeast Sweden, were asked to

answer a questionnaire regarding the presence of any kind of atopic

manifestations. The questionnaire was also sent to 930 controls

collected from the Southeastern Region Population Registry. The

controls were matched according to age, sex, and place of residence.

RESULTS: The response rate among the Crohn patients was 91% (280/308)

and among controls 84% (779/930). Eczema was a significantly more

frequent manifestation, being almost twice as common in Crohn

patients (27%) as in the general population (16%). Adjustment by

logistic regression for place of residence, gender, age and

coexistence of any other atopic manifestation did not change the odds

ratios significantly. CONCLUSION: Atopic manifestations as a group,

and eczema as a single manifestation, are significantly more frequent

in Crohn patients than in the general population. PMID: 15513357.

Does your Dad have Crohn's disease or ulcerative colitis, or neither?

Best regards,

Dave

(father of (22), PSC 07/03, UC 08/03)

> My Dad has PSC and allergies and has recently developed excema. I

know that itching is a symptom of PSC, but does anyone know if PSC

is linked with excema?

[Guest guest]

Hi Dave. Thanks for responding so quickly.

My Dad had UC, but recently had an colostomy. His PSC became

sympomatic after the surgery and since then his energy is low, his

skin is sallow, and he's developed excema. I'm just trying to figure

out how much of his condition is surgery related (and therefore

temporary) and how much is PSC.

- Alison

> > My Dad has PSC and allergies and has recently developed excema.

I

> know that itching is a symptom of PSC, but does anyone know if PSC

> is linked with excema?

>

[Guest guest]

I became PSC symptomatic 3 months after my colon

surgery. and from time to time I get Eczema too, but

then it disappears.

Cindy Baudoux-Northrup

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[Guest guest]

Suzanne has just developed what looks to

me like excema. I never even wondered about an association until I started

reading these posts – this is why this group is so important.

LINDA

(Mom of Suzanne, 18; UC 1/04; PSC 3/04; jpouch 2/07)

From:

[mailto: ] On

Behalf Of alisonb42001

Sent: Friday, August 31, 2007

12:36 AM

To:

Subject: PSC &

Excema

Hi all,

My Dad has PSC and allergies and has recently developed excema. I know

that itching is a symptom of PSC, but does anyone know if PSC is linked

with excema?

Thanks,

Alison