Body Mass Index in Children with Newly Diagnosed Inflammatory Bowel Disease

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The Journal of Pediatrics

doi:10.1016/j.jpeds.2007.04.004 Copyright © 2007 Mosby, Inc. All rights reserved.

Body Mass Index in Children with Newly Diagnosed Inflammatory Bowel Disease: Observations from Two Multicenter North American Inception Cohorts

Subra Kugathasan MD, , Nebel BA, ph A. Skelton MD, Markowitz MD, Keljo MD, PhD, Rosh MD, Neal LeLeiko MD, Mack MD, Anne Griffiths MD, FRCP©, Athos Bousvaros MD, MPH, MD, Adam Mezoff MD, Moyer MD, Oliva-Hemker MD, Otley MD, nn Pfefferkorn MD, Wallace Crandall MD, Wyllie MD, Hyams MD and Wisconsin Pediatric Inflammatory Bowel Disease Alliance and Pediatric Inflammatory Bowel Disease Collaborative Research Group Received 4 October 2006; revised 8 February 2007; accepted 5 April 2007. Available online 24 August 2007.

Objective To conduct a systematic review of children with newly diagnosed inflammatory bowel disease (IBD) from 2 prospective inception cohorts to examine body mass index (BMI) status at presentation. Study design Clinical, demographic, and BMI data were obtained from 783 patients with newly diagnosed IBD. National Health and Nutrition Examination Survey data for 2748 healthy children were used as a control. Results Most children with Crohn's disease and ulcerative colitis had a BMI in the normative range (5%-84%). Low BMI (<5%) was seen in 22% to 24% of children with Crohn's disease and 7% to 9% of children with ulcerative colitis. Ten percent of children with Crohn's disease and 20% to 30% of children with ulcerative colitis had a BMI at diagnosis consistent with overweight or risk for overweight. Conclusion Children with IBD are affected by current population trends toward overweight. A significant subgroup of children with newly diagnosed IBD has a BMI categorized as overweight or at risk for overweight. Clinicians should be aware of possible IBD diagnosis in the presence increased BMI. Abbreviations: BMI, Body mass index; CD, Chron's disease; IBD, Inflammatory bowel disease; NCHS, National Center for Health Statistics; NHANES, National Health and Examination surveys; UC, Ulcerative colitis

From the Medical College of Wisconsin, Milwaukee, WI (S.K., J.N., J.A.S.); North Shore-Long Island Jewish Health System, New Hyde Park, NY (J.M.); Children's Hospital of Pittsburgh, Pittsburgh, PA (D.K.); town Memorial Hospital, town, NJ (J.R.); Hasbro Children's Hospital, Providence, RI (N.L.); Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada (D.M.); Hospital for Sick Children, Toronto, Ontario, Canada (A.G.); Children's Hospital, Boston, MA (A.B.); Nemours Children's Clinic, ville, FL (J.E.); Children's Medical Center, Dayton, OH (A.M.); Children's Hospital Medical Center, Cincinnati, OH (S.M.); s Hopkins Hospital, Baltimore, MD (M.O.-H.); IWK Health Centre, Halifax, Nova Scotia (A.O.); Riley Hospital for Children, Indianapolis, IN (M.P.); Columbus Children's Hospital, Columbus, OH (W.L.); Cleveland Clinic, Cleveland, OH (R.W.); and Connecticut Children's Medical Center, Hartford, CT (J.H.).