PBC-PSC overlap

[Guest guest]

Hi Chaim;

PBC and PSC have been found to overlap in some rare instances:

Eur J Gastroenterol Hepatol. 2005 Oct;17(10):1077-80.

Co-existence of primary biliary cirrhosis and primary sclerosing

cholangitis: a rare overlap syndrome put in perspective.

Kingham JG, Abbasi A

Department of Gastroenterology, Singleton Hospital, Swansea, UK.

jkingham@...

Overlap syndromes between autoimmune hepatitis and both primary

biliary cirrhosis and primary sclerosing cholangitis are well

described, but overlap between primary biliary cirrhosis and primary

sclerosing cholangitis is not recognized. We present two cases of an

unusual autoimmune liver disease, both of which included an overlap

between primary biliary cirrhosis and primary sclerosing cholangitis,

while one had features of all three conditions. The diagnoses were

based on clinical, biochemical, serological, histological and

cholangiographic findings. The two cases were identified from a

consecutive cohort of 261 patients with autoimmune liver disease

followed prospectively in secondary care over a 20-year period, which

gives perspective to this uncommon overlap syndrome. PMID: 16148553

Best regards,

Dave R.

> The strange thing is that AIH overlaps with PSC, or with PBC

(another bilary disease) but PSC and PBC supposedly do not overlap.