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,Wow! You finally got some Estrace, that is great, though, I'm sorry to hear that it bothered your urethra. Maybe some compounded Estradiol 'would' be the way for you to go. If you go back and read Dee's story -- she actually still hurt while using the Estrace, until it thickened the skin. It still may be hormonal, as the urethra has E. receptors located in it, too. Just a thought. I hope you find the answers you need. Just don't give up! Take Care,Chelle

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