Guest guest Posted October 2, 2007 Report Share Posted October 2, 2007 World J Gastroenterol. 2007 Nov 7;13(41):5421-31. Genetic epidemiology of primary sclerosing cholangitis. Karlsen TH, Schrumpf E, Boberg KM Medical Department, Rikshospitalet-Radiumhospitalet Medical Center, N- 0027 Oslo, Norway. t.h.karlsen@.... The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 80-fold increased risk of PSC among first-degree relatives emphasizes the importance of genetic factors. Genetic associations within the human leukocyte antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. Subsequent studies have substantiated beyond doubt that one or more genetic variants located within this genetic region are important. The true identities of these variants, however, remain to be identified. Several candidate genes at other chromosomal loci have also been investigated. However, according to strict criteria for what may be denominated a susceptibility gene in complex diseases, no such gene exists for PSC today. This review summarises present knowledge on the genetic susceptibility to PSC, as well as genetic associations with disease progression and clinical subsets of particular interest (inflammatory bowel disease and cholangiocarcinoma). PMID: 17907284. The full text of this article is available (free) at: http://www.wjgnet.com/1007-9327/13/5421.asp Dr. Karlsen is the recipient of the 2007 PSC Partners Seeking a Cure Prize at the AASLD. Best regards, Dave (father of (23); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 2, 2007 Report Share Posted October 2, 2007 > > World J Gastroenterol. 2007 Nov 7;13(41):5421-31. > > Genetic epidemiology of primary sclerosing cholangitis. > > Karlsen TH, Schrumpf E, Boberg KM > > Medical Department, Rikshospitalet-Radiumhospitalet Medical Center, N- > 0027 Oslo, Norway. t.h.karlsen@... > >> http://www.wjgnet.com/1007-9327/13/5421.asp Hi thanks so much for the article, I will have to digest it very slowly with the help of Wikipedia. I have found the PDF version easier to read. http://www.wjgnet.com/1007-9327/13/5421.pdf Thanks again from the bottom of the world in New Zealand. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.