Effectiveness of probiotics therapy (BIO-THREE) patients with UC

[Guest guest]

Clinical

effectiveness of probiotics therapy (BIO-THREE) in

patients with ulcerative colitis refractory to conventional therapy

Authors:

Yukiko Tsuda; Yasushi Yoshimatsu; Hiroshi Aoki; Kentaro

Nakamura ; Masaki Irie; Katsuyuki Fukuda; Nobuo Hosoe;

Nobuo Takada; Koji Shirai; Yasuo

Suzuki

Affiliation:

a Department of Internal

Medicine, Sakura Medical

Center, Toho

University, Chiba,

Japan

Published in:

Scandinavian

Journal of Gastroenterology, Volume 42,

Issue 11 2007

,

Abstract

Objective. Intestinal

microflora has been implicated in the etiology of

ulcerative colitis (UC). Over the past few years,

the use of probiotics in UC has gained attention. The aim of this study was to evaluate the efficacy of probiotics therapy for mild to moderate distal UC

refractory to conventional therapies.

Material and

methods.

Twenty patients with mild to moderate

distal UC took 9 BIO-THREE tablets per day for 4 weeks. Clinical

symptoms and endoscopic findings were evaluated as

ulcerative colitis disease activity index (UCDAI) scores before and after

administration of BIO-THREE. Fecal samples were

collected from all patients before and after probiotics

administration, and fecal microflora was analyzed

by the terminal restriction fragment length polymorphism (T-RFLP) method.

Results. Remission

(UCDAI score2) was observed in 45% (9/20)

of the patients; response (decrease in UCDAI3, but

final score3) in 10% (2/20); no response

in 40% (8/20); and worsening (UCDAI>3) in 5% (1/20). T-RFLP analysis

indicated that the principal alteration in microflora

was an increase in bifidobacteria.

Conclusions. This

study showed that administration of BIO-THREE improved the clinical symptoms

and endoscopic findings in patients with UC, indicating

that administration of BIO-THREE is safe and efficacious for the treatment of

UC.

With love, Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (33) UC 91 - PSC 99 - Tx 6/21 & 6/30/07 @ Baylor in Dallas

[Guest guest]

Hi Barb

Is there any way to get the full article? I went to the links you gave

and all I got was the abstract. I have an upcoming appointment with my

hepatologist/gastroenterologist in about 2 weeks and I'd like to see

about either discontinuing my meds for the UC or perhaps finding some

alternatives as I've been asymptomatic for UC for quite some time.

>

> Clinical effectiveness of probiotics therapy (BIO-THREE) in patients

> with ulcerative colitis refractory to conventional therapy

>

> Authors: Yukiko Tsuda; Yasushi Yoshimatsu; Hiroshi Aoki; Kentaro

> Nakamura ; Masaki Irie; Katsuyuki Fukuda; Nobuo Hosoe; Nobuo Takada;

> Koji Shirai; Yasuo Suzuki

>

Thanks