Genetic factors associated with the development of inflammatory bowel disease

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Yamamoto-Furusho JK.Genetic factors associated with the development of inflammatory bowel disease.World J Gastroenterol 2007 November;13(42):5594-5597Genetic factors associated with the development of inflammatory bowel diseaseYamamoto-Furusho JK.Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Col. Seccion XVI, Tlalpan, Mexico, D.F., Mexico. kazuofurusho@...Crohn's disease (CD) and ulcerative colitis (UC) are complex polygenic disorders, characterized by several genes together with environmental factors contributing to the development of inflammatory bowel disease (IBD). Recent advances in research on genetic susceptibility have allowed the identification of diverse genes at different levels: (1) Innate immunity; (2) Antigen presentation molecules; (3) Epithelial integrity; (4) Drug transporter; (5) Cell adhesion. The application of genetic testing into clinical practice is close and all genetic markers may have several clinical implications: prediction of disease phenotype, molecular classification, prevention of complications, and prognosis.