low temp?

[Guest guest]

So I'm still pretty new at this PSC thing (diagnosed Oct. 1) and learning as I

go. I took my

temp this evening because I wasn't feeling too well and it read 95.7F... twice.

Is this

something I should be concerned about?

[Guest guest]

For me my base temp is 96.8 so a low temp is not that abnormal, but you want to make sure that you do not take your temp within 30 mins of eating or drinking anything as this can have an effect on it.

Sandi

[Guest guest]

I think this is relatively common. There was a series of messages on this topic in the archives. See messages 33666, 33677, 33690, 33698, 33705, 33715 for example.

" I am not sure that Ty's lower temperature is unique to this group. Before tx, I always ran in the high 96s to low 97s. Now, I am high 95s to low 96s. In the morning, I am usually between 93-94. Strange but now considered normal for me. "

Darin

98.6 F is an average, with some people on both extremes. I don't know if PSCers are typically on the low end (I'm not). Maybe a topic for a poll?

Arne

56 - UC 1977, PSC 2000

Alive and (mostly) well in Minnesota

________________________________

From: [mailto: ] On Behalf Of Jillian Meseth

So I'm still pretty new at this PSC thing (diagnosed Oct. 1) and learning as I go. I took my

temp this evening because I wasn't feeling too well and it read 95.7F... twice. Is this

something I should be concerned about?

[Guest guest]

Arne,My son also runs a low normal temp.If it was found that all PSCers ran lower than normal temps, could this be somethingthat could affect something internally, like bacteria? Lee98.6 F is an average, with some people on both extremes.  I don't know if PSCers are typically on the low end (I'm not).  Maybe a topic for a poll?Arne 56 - UC 1977, PSC 2000 Alive and (mostly) well in Minnesota________________________________

[Guest guest]

I find this very interesting. My own temp runs 96.7 and it is frustrating when

you are sick as a dog and you are told that " well your temp is only 99 " . A temp

of 99 for me high and it is sometimes hard to get medical personnel to listen to

that.

>>> leedeubert 11/16/2007 6:56 AM >>>

Arne,

My son also runs a low normal temp.

If it was found that all PSCers ran lower than normal temps, could

this be something

that could affect something internally, like bacteria?

Lee

>

> 98.6 F is an average, with some people on both extremes. I don't

> know if PSCers are typically on the low end (I'm not). Maybe a

> topic for a poll?

>

> Arne

> 56 - UC 1977, PSC 2000

> Alive and (mostly) well in Minnesota

>

> ________________________________

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[Guest guest]

My temp also runs low. I feel feverish if it's 99, which rarely happens. It's usually in the 96 to 97 range, but sometimes it's in the 98 range. I think it has been as low as in the upper 95 range.

Marie

Peek-a-boo FREE Tricks Treats for You! Get 'em!

[Guest guest]

Wilkinson wrote:

> I find this very interesting. My own temp runs 96.7 and it is frustrating

when you are sick as a dog and you are told that " well your temp is only 99 " . A

temp of 99 for me high and it is sometimes hard to get medical personnel to

listen to that.

>

My temp always ran low before my transplant, quite a bit low in the last

few months. I'd be chilled like I had a fever and take my temp and it

would be around 96.5 or so. One trick I found when talking to doctors

is that if they asked me if I had a fever I'd tell them that I felt

feverish, list the symptoms, (chills, aches, etc.) and then say that my

temp was elevated 2 degrees (or whatever) rather than giving them the

exact number. So if my temp had been running 97 when I felt normal, and

now it was 98.5 I'd say my temp was 1.5 degrees elevated. Of course

that doesn't work when you're in the doctors office and they take your temp!

Now my temp seems to run pretty much normal, so I think the low temp was

related to PSC.

athan

[Guest guest]

It seems like the poll is showing that most PSCers run a low body temp.How can this be significant to the disease? Could say, a low body temp keep a goodbacteria from flourishing ? Could a low body temp somehow change the immune system tobecome overactive just as a high temp does?  Just wondering how body temperaturecould be involved. Thoughts ?Also I would like to hear from those with successful transplants on how many of them likeathan now run normal temperatures.Lee Wilkinson wrote:> I find this very interesting. My own temp runs 96.7 and it is frustrating when you are sick as a dog and you are told that "well your temp is only 99". A temp of 99 for me high and it is sometimes hard to get medical personnel to listen to that.> My temp always ran low before my transplant, quite a bit low in the last few months. I'd be chilled like I had a fever and take my temp and it would be around 96.5 or so. Now my temp seems to run pretty much normal, so I think the low temp was related to PSC.athan

[Guest guest]

> Also I would like to hear from those with successful transplants on

> how many of them like

> athan now run normal temperatures.

My temperature hasn't changed since transplant. Average is still about

97.7 although this morning's reading was a bit lower at 97.3. At 100 I

know I've got a fever that is worth taking seriously.

Tim R, tx #3 7/7/07

[Guest guest]

I have always run low temps, before and after TX. The difference pre and post is that now I don't feel cold, and pre I was freezing. Don Please be a blood/organ donor

Get easy, one-click access to your favorites. Make Yahoo! your homepage.

[Guest guest]

Hi Lee;

Good questions! I wish I knew the answers. There is certainly an

involvement of the brain (specifically the hypothalmus) in

controlling body temperature, and maybe inflammatory cytokines that

traverse the blood-brain barrier can influence this temperature

sensor in the brain? But it is likely very complex ... perhaps this

is something that 's husband, Fred, could comment on?

The immune system could possibly affect core body temperature, as

indicated in this article:

Nat. Immunol. 5: 575-581 (2004)

Elaborate interactions between the immune and nervous systems.

Steinman L

Department of Neurological Sciences and Neurology and Pediatrics,

Interdepartmental Program in Immunology, Beckman Center for Molecular

Medicine,Stanford, California 94305, USA. steinman@...

The immune system and the nervous system maintain extensive

communication, including 'hardwiring' of sympathetic and

parasympathetic nerves to lymphoid organs. Neurotransmitters such as

acetylcholine, norepinephrine, vasoactive intestinal peptide,

substance P and histamine modulate immune activity. Neuroendocrine

hormones such as corticotropin-releasing factor, leptin and

alpha-melanocyte stimulating hormone regulate cytokine balance. The

immune system modulates brain activity, including body temperature,

sleep and feeding behavior. Molecules such as the major

histocompatibility complex not only direct T cells to immunogenic

molecules held in its cleft but also modulate development of neuronal

connections. Neurobiologists and immunologists are exploring common

ideas like the synapse to understand properties such as memory that

are shared in these two systems. PMID: 15164017.

Some interesting thoughts on body temperature can be found in this

article: Life, the Universe, and Body Temperature, by Clifford B.

Saper, Science 3 November 2006: Vol. 314. no. 5800, pp. 773 - 774.

http://www.sciencemag.org/cgi/content/full/314/5800/773

It's a commentary on an article by Conti et al. who produced

transgenic mice in which they expressed a protein which gives off

energy as heat (from ATP) in the hypothalmus. Effectively they placed

a small heater into the hypothalamus! This caused heating of the

temperature sensor in the brain. The mice were thus " tricked " into

lowering their body temperature by 0.3° to 0.5°C. Surprisingly these

mice showed a 10 - 20% INCREASE in life-span.

Best regards,

Dave R.

> It seems like the poll is showing that most PSCers run a low body

temp. How can this be significant to the disease? Could say, a low

body temp keep a good bacteria from flourishing ? Could a low body

temp somehow change the immune system to become overactive just as a

high temp does? Just wondering how body temperature could be

involved. Thoughts ?

[Guest guest]

Hi Dave,I did a search on "Search and Give" and found an article to send you.I know the first couple times we checked Bill's temperature and saw it was closer to 97 than 98. Ithought something was wrong with my thermometer so I got a new one. Same thing.I wondered then if this was something tied to all his problems. Anyway, I think it might be a good idea to give a few tips to  our group on how to warm up !!Thanks for looking into this,LeeHi Lee;Good questions! I wish I knew the answers. There is certainly an involvement of the brain (specifically the hypothalmus) in controlling body temperature, and maybe inflammatory cytokines that traverse the blood-brain barrier can influence this temperature sensor in the brain? But it is likely very complex ... perhaps this is something that 's husband, Fred, could comment on? The immune system could possibly affect core body temperature, as indicated in this article:Nat. Immunol. 5: 575-581 (2004)Elaborate interactions between the immune and nervous systems.Steinman LDepartment of Neurological Sciences and Neurology and Pediatrics,Interdepartmental Program in Immunology, Beckman Center for Molecular Medicine,Stanford, California 94305, USA. steinman (AT) stanford (DOT) eduThe immune system and the nervous system maintain extensive communication, including 'hardwiring' of sympathetic and parasympathetic nerves to lymphoid organs. Neurotransmitters such as acetylcholine, norepinephrine, vasoactive intestinal peptide, substance P and histamine modulate immune activity. Neuroendocrine hormones such as corticotropin-releasing factor, leptin andalpha-melanocyte stimulating hormone regulate cytokine balance. The immune system modulates brain activity, including body temperature, sleep and feeding behavior. Molecules such as the major histocompatibility complex not only direct T cells to immunogenic molecules held in its cleft but also modulate development of neuronal connections. Neurobiologists and immunologists are exploring commonideas like the synapse to understand properties such as memory that are shared in these two systems. PMID: 15164017.Some interesting thoughts on body temperature can be found in this article: Life, the Universe, and Body Temperature, by Clifford B. Saper, Science 3 November 2006: Vol. 314. no. 5800, pp. 773 - 774.http://www.sciencemag.org/cgi/content/full/314/5800/773It's a commentary on an article by Conti et al. who produced transgenic mice in which they expressed a protein which gives off energy as heat (from ATP) in the hypothalmus. Effectively they placed a small heater into the hypothalamus! This caused heating of the temperature sensor in the brain. The mice were thus "tricked" into lowering their body temperature by 0.3° to 0.5°C. Surprisingly these mice showed a 10 - 20% INCREASE in life-span.Best regards,Dave R.--- 

[Guest guest]

I bought and threw away 3 digital thermometers before it sunk in that I was the

one with the problem and not the thermometer.

I work in a Hospital and you know hospitals are always cold. I freeze all the

time. I never run the air conditioner in the summer. There are 4 other offices

that share a ac/heating unit with me and the other 4 occupants do not share my

temperature problems. They complain about my office being too warm and they

really complain when they come in and I have had to ask maint. guys to turn on

the heat. I have been told that I need to " get some meat on my bones " or that

" my blood needs thickening up " .

In my old office I could run a portable heater but in my new one, I blow the

circuits when I plug one in. I have learned to wear long sleeves under my

scrubs and to keep a jacket and blanket with me at all times in my office. I

even try to keep a blanket in the car so everybody can be comfortable. I figure

it is easier for me to cover up than it is for everybody else to disrobe. lol

>>> " athan " 11/18/2007 5:25 AM >>>

Wilkinson wrote:

> I find this very interesting. My own temp runs 96.7 and it is frustrating

when you are sick as a dog and you are told that " well your temp is only 99 " . A

temp of 99 for me high and it is sometimes hard to get medical personnel to

listen to that.

>

My temp always ran low before my transplant, quite a bit low in the last

few months. I'd be chilled like I had a fever and take my temp and it

would be around 96.5 or so. One trick I found when talking to doctors

is that if they asked me if I had a fever I'd tell them that I felt

feverish, list the symptoms, (chills, aches, etc.) and then say that my

temp was elevated 2 degrees (or whatever) rather than giving them the

exact number. So if my temp had been running 97 when I felt normal, and

now it was 98.5 I'd say my temp was 1.5 degrees elevated. Of course

that doesn't work when you're in the doctors office and they take your temp!

Now my temp seems to run pretty much normal, so I think the low temp was

related to PSC.

athan

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[Guest guest]

said: "There is certainly an involvement of the brain (specifically the hypothalmus) in controlling body temperature, and maybe inflammatory cytokines that traverse the blood-brain barrier can influence this temperature sensor in the brain? But it is likely very complex ... perhaps this is something that 's husband, Fred, could comment on? "

Hi Dave. You give me way too much credit. However, now that this has been mentioned, and I think about it, I think my own temp has probably been about a degree below the normal 98.6 that it use to be, b/f I had PSC/UC.

OTOH, ’s temp has always been a degree or two below normal and she's quite healthy with no problems as far as we know. (Probably just a thyroid thing??) So I don’t know what all this means, if anything.

Another thing, maybe sort of related, is that I’ve always tended to sweat a lot, I think more than “normal,” during physical exertion or in hot temperatures, but it seems that now with the PSC/UC I’ll sweat even more and sometimes will continue to sweat taking me longer to cool down. But then maybe it’s just that I’m getting old?

Fred

[Guest guest]

That's what I always struggle with. Is (enter symptom here) because of PSC, UC

or just age? Hopefully, I'll be able to ask that question for a long time.

Arne

---- " Fred H. " wrote:

=============

....But then maybe it's just that I'm getting old?

Fred

[Guest guest]

Hi Lee, and everyone else interested in the apparently low basal

temperature of many PSCers;

I've been trying to come up with a possible explanation for the low

basal temperature that many of you are reporting. One of the main

mechanisms of thermogenesis (heat generation) in the mammalian body

seems to be from the 'burning' of fats in adipose tissue. This

process appears to be strongly regulated by retinoic acid (derived

from vitamin A), see for example:

__________________________

Nutr. Rev. 1995 Aug;53(8):230-1.

A regulatory pathway of thermogenesis in brown fat through retinoic

acid.

Wolf G.

University of California at Berkeley, USA.

Thermogenesis in brown adipose tissue is achieved by the enzyme that

uncouples the respiratory chain from oxidative phosphorylation. This

enzyme is regulated by the sympathetic nervous system and, as

recently discovered, by transcriptional regulation through retinoic

acid (RA). Thus, RA is involved in heat production and, hence, in the

regulation of energy balance. PMID: 7501309.

__________________________

One could imagine that vitamin A deficiency might result in low

retinoic acid levels and impaired heat production and energy balance?

As I've mentioned before, retinoic acid seems to crop up in a lot of

places that I've been reading on PSC/UC lately. Here are a few

examples:

* Retinoic acid helps maintain epithelial integrity in colitis:

Osanai M, Nishikiori N, Murata M, Chiba H, Kojima T, Sawada N 2007

Cellular retinoic acid bioavailability determines epithelial

integrity: role of retinoic acid receptor alpha agonists in colitis.

Mol. Pharmacol. 71: 250-258.

* Retinoic acid increases the production of anti-inflammatory

regulatory T cells at the expense of pro-inflammatory Th17 cells:

Mucida D, Park Y, Kim G, Turovskaya O, I, Kronenberg M,

Cheroutre H 2007 Reciprocal Th-17 and regulatory T cell

differentiation mediated by retinoic acid. Science 317: 256-260.

* Retinoic acid imprints T cells with 'gut-homing' properties:

Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY 2004

Retinoic acid imprints gut-homing specificity on T cells. Immunity

21: 527-538.

* Retinoic acid suppresses inflammation by down-regulation nuclear

factor-kappaB activity:

Austenaa LM, Carlsen H, Ertesvag A, G, Blomhoff HK,

Blomhoff R 2004 Vitamin A status significantly alters nuclear factor-

kappaB activity assessed by in vivo imaging. FASEB J. 18: 1255-1257.

* Many of the enzymes of bile metabolism and transport in the liver

are regulated by the retinoid X receptor (RXR), which is activated by

9-cis-retinoic acid (and/or docosahexaenoic acid (DHA)). This is

accomplished by the RXR forming dimers with other receptors such as

the pregnane X receptor, and then regulating gene expression (see the

newsletter article on Inflammation and Cholestasis):

http://www.pscpartners.org/NewsVol-2-4.pdf

I'd be curious if low-basal body temperature correlated with vitamin

A deficiency?

Best regards,

Dave R.

>

> It seems like the poll is showing that most PSCers run a low body

temp. How can this be significant to the disease?

[Guest guest]

>

> Hi Lee, and everyone else interested in the apparently low basal

> temperature of many PSCers;

>

> I've been trying to come up with a possible explanation for the low

> basal temperature that many of you are reporting. One of the main

> mechanisms of thermogenesis (heat generation) in the mammalian body

> seems to be from the 'burning' of fats in adipose tissue. This

> process appears to be strongly regulated by retinoic acid (derived

> from vitamin A), see for example:

Hi

Are you by any chance Sherlock Holmes GreatGreat Grandson!! We set

you a problem and we know that sooner or later a post will appear

with a possible answer. Its amazing!!!!

I was hospitalised 3 months ago, with antibiotics for a bile duct

infection. My temperature was always low, (during my time in hospital

after I stabilised, the nurses were slightly concerned with the low

temp, but I kept saying it was normal for me) then when this

discussion started several weeks ago I took my temperature and was

amazed to find it now is 36.8 (98.2). I have kept checking on it, but

it always comes up as 36.8.

Thanks