SchaferAutismReport: Evidence Found for the Genetic Basis of Autism: Models of Autism Show That Gene

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RESEARCHEvidence Found for the Genetic Basis of Autism: Models of Autism Show That Gene Copy Number Controls Brain Structure and Behavior

This three-dimensional representation of the mouse brain highlights eight regions (shown with different colors) affected by 16.p11.2 deletion. (Credit: Image courtesy of Mills@CSHL) ScienceDaily — Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on

chromosome 16 -- causes autism-like features. By generating mouse models of autism using a technique known as chromosome engineering, CSHL Professor Alea Mills and colleagues provide the first functional evidence that inheriting fewer copies of these genes leads to features resembling those used to diagnose children with autism. The study appears in the Proceedings of the National Academy of Sciences in the early online edition during the week of October 3. "Children normally inherit one copy of a gene from each parent. We had the tools to see whether copy number changes found in kids with autism were causing the syndrome," explains Mills. In 2007, Professor Wigler, also at CSHL, revealed that some children with autism have a small deletion on chromosome 16, affecting 27 genes in a region of our genomes referred to as 16p11.2. The deletion -- which causes children to inherit

only a single copy of the 27-gene cluster -- is one of the most common copy number variations (CNVs) associated with autism. "The idea that this deletion might be causing autism was exciting," says Mills. "So we asked whether clipping out the same set of genes in mice would have any effect." After engineering mice that had a chromosome

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RESEARCHEvidence Found for the Genetic Basis of Autism: Models of Autism Show That GeneNew Mouse Model Recreates Common Form of AutismAccelerated Early Growth Linked to AutismUC MIND Institute MARBLES Study Receives $10 Million NIH Grant GrantUC Health System Designated A National Neuroscience Clinical Trials SiteNEWSObama Signs Autism Act PUBLIC HEALTHChemical Makers Say BPA No Longer Used In Bottles PEOPLEAunt Wins Custody Of Fatherless Autistic B.C. BoyEDUCATIONIndiana Appeals Court Backs Teacher's Handling Of Disruptive PupilParents Claim Abuse Of Special Needs Students

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