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Estrogen (Estradiol) LevelsEstradiol is the primary human estrogen -- and when your ovaries begin to fail, your circulating estradiol levels drop. This is why doctors often give you a serum estradiol concentration test to measure the amount of estradiol in your blood. In this case, the doctor is looking to see if your estrogen levels are lower than normal -- again, a signal of ovarian failure, or, in other words, early menopause.

Normal estradiol Day 3 value -- 25-75 pg/ml

In spite of the above number, generally, estradiol levels about 30 or below -- in conjunction with a high FSH level (high in this case, meaning in the post-menopausal range, i.e. 30-40 or higher) -- is considered menopausal. (Important note: If your FSH hasn't reached post-menopausal levels and your estradiol is on the low side, you are not considered POF or EM. There can be other reasons for low estradiol, including excessive exercise, low body fat, and diminished ovarian reserve.) This is because estradiol levels tend to drop over time. During the first 2 to 5 years following menopause or ovarian failure, blood levels of estradiol drop to an average range of about 25 to 35 pg/ml. Women not on HRT generally will see this number drop even more over time; after about five years, it's common for menopausal women who aren't on HRT to have estradiol levels below 25.

If your estradiol levels are lower than 50 picograms per milliliter, you may still be having a period, but also may be experiencing symptoms of low estrogen -- including hot flashes, vaginal dryness, and sleep difficulties.

Non-menopausal:

Follicular Phase

24-138

Luteal Phase

19-164

Periovulatory

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