Re: Cholangiocarcinoma in PSC after long-time treatment with ursodeoxycholic aci

[Guest guest]

Thank you Barb for this paper, very positive results for those, who have been on

urso for a

longer time (quite many of the group members, I believe) and for all, who take

or will take

urso.

, UC & small duct PSC '83, large duct PSC in 90ties, AIH overlap 2007

>

> Eur J Gastroenterol Hepatol. 2007 Jun ;19 (6):487-91 17489059

>

> <http://lib.bioinfo.pl/pmid:17489059> The incidence of

> cholangiocarcinoma in primary sclerosing cholangitis after long-time

> treatment with ursodeoxycholic acid. [My paper]

>

> <http://lib.bioinfo.pl/auth:Rudolph,G> Gerda Rudolph ,

> <http://lib.bioinfo.pl/auth:Kloeters-Plachky,P> Petra Kloeters-Plachky ,

> <http://lib.bioinfo.pl/auth:Rost,D> Rost ,

> <http://lib.bioinfo.pl/auth:Stiehl,A> Adolf Stiehl

>

> BACKGROUND/AIMS: Cholangiocarcinoma represents a serious complication of

> primary sclerosing cholangitis. Ursodeoxycholic acid may possibly

> influence the incidence of cholangiocarcinoma in man. The aim of this

> study was to evaluate the incidence rate of cholangiocarcinoma in a

> large group of primary sclerosing cholangitis patients after long-time

> treatment with ursodeoxycholic acid. PATIENTS AND METHODS: From May 1987

> up to May 2005 a total of 150 patients with primary sclerosing

> cholangitis but without evidence of cholangiocarcinoma at entry were

> included in the study. All patients were treated with ursodeoxycholic

> acid and controls were performed in at least yearly intervals. RESULTS:

> The median treatment time of the 150 patients was 6.4 years. Altogether

> five patients developed a cholangiocarcinoma during treatment yielding a

> rate of 3.3%. The patients developed 0.58 cholangiocarcinoma per 100

> patient-years in years 0-2.5, 0.59 cholangiocarcinoma in years 2.5-8.5,

> and no cholangiocarcinoma thereafter up to 18 years after entry into the

> study. The Kaplan-Meier estimate of cholangiocarcinoma incidence during

> ursodeoxycholic acid treatment reached a plateau after 8.3 years.

>

> SUMMARY AND CONCLUSION: The annual incidence rate of cholangiocarcinoma

> in primary sclerosing cholangitis treated with ursodeoxycholic acid is

> lower than expected and decreases with time of treatment.

>

> Barb in Texas - Together in the Fight, Whatever it Takes!

> Son Ken (33) UC 91 - PSC 99 - Tx 6/21 & 6/30/07 @ Baylor in Dallas

>