Guest guest Posted January 23, 2008 Report Share Posted January 23, 2008 The Dutch news have just reported that a research project from the Academic Hospital in Utrecht has had stunning and unexpected disastrous results. It concerned a double blind trial giving probiotic therapy to 300 patienten in the last 3 years, suffering from pancreatitis. The idea was to see if giving probiotics reduced the incidence of developing (or improved the outcome of those with) infected necrotising pancreatitis. The shocking results showed that 24 patients in the probiotic group died and only 9 in the non treated group. There have been "successes" reported in foreign literature but the numbers were smaller and the patients apparently less sick at beginning of therapy. The researchers conclusions are that probiotics should NOT be given to "those that are very sick at admission". The reason it has taken them so long to know this is because only today the "key" as to which patients had received the probiotics and which hadn't was "broken". To be taken into account I think is that the mortality from this complication is high in any case, although there clearly were huge differences. As a survivor of infected necrotising pancreatitis myself I think I have to be glad I was treated before this study commenced.... otherwise I might well have been in the "bad" group! DutchPat Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2008 Report Share Posted January 23, 2008 I live in Holland too and I saw it on the news too. Which products are considered probiotic ones? Silvia > > > The Dutch news have just reported that a research project from the Academic Hospital in Utrecht has had stunning and unexpected disastrous results. > It concerned a double blind trial giving probiotic therapy to 300 patienten in the last 3 years, suffering from pancreatitis. The idea was to see if giving probiotics reduced the incidence of developing (or improved the outcome of those with) infected necrotising pancreatitis. > The shocking results showed that 24 patients in the probiotic group died and only 9 in the non treated group. There have been " successes " reported in foreign literature but the numbers were smaller and the patients apparently less sick at beginning of therapy. > The researchers conclusions are that probiotics should NOT be given to " those that are very sick at admission " . > The reason it has taken them so long to know this is because only today the " key " as to which patients had received the probiotics and which hadn't was " broken " . > > To be taken into account I think is that the mortality from this complication is high in any case, although there clearly were huge differences. > > As a survivor of infected necrotising pancreatitis myself I think I have to be glad I was treated before this study commenced.... otherwise I might well have been in the " bad " group! > > DutchPat > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2008 Report Share Posted January 23, 2008 I'm assuming that it's this trial: Probiotic prophylaxis in patients with predicted severe acute pancreatitis (PROPATRIA): design and rationale of a double-blind, placebo-controlled randomised multicenter trial [iSRCTN38327949] Marc GH Besselink*1, Harro M Timmerman1, Buskens2, B Nieuwenhuijs1, Louis MA Akkermans1, Hein G Gooszen1 and the members of the Dutch Acute Pancreatitis Study Group Address: 1Department of Surgery, University Medical Center Utrecht PO Box 85500, HP G04.228, 3508 GA Utrecht, The Netherlands and 2Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht PO Box 85060, 3500 AB Utrecht, The Netherlands http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=526218 If this is the correct trial, then they are using a product called " Ecologic 641 " : " Ecologic® 641 consists of 6 strains of viable and freeze-dried bacteria, namely 4 lactobacilli: Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus salivarius, Lactococcus lactis, and 2 bifidobacteria: Bifidobacterium bifidum and Bifidobacterium lactis in a total daily dose of 10(10) bacteria. " Dave R. > > I live in Holland too and I saw it on the news too. > Which products are considered probiotic ones? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2008 Report Share Posted January 23, 2008 Pat and Sylvia, That is interesting. I didn't know there were any dutchies on the PSC forum. I am originally from Holland but now live in Israel. Is there any dutch liver group (stichting) that deals specifically with PSC? I haven't found anything. Regards, Chaim Boermeester From: [mailto: ] On Behalf Of schar1968 Sent: Wednesday, January 23, 2008 22:15 To: Subject: Re: breaking news in Holland I live in Holland too and I saw it on the news too. Which products are considered probiotic ones? Silvia > > > The Dutch news have just reported that a research project from the Academic Hospital in Utrecht has had stunning and unexpected disastrous results. > It concerned a double blind trial giving probiotic therapy to 300 patienten in the last 3 years, suffering from pancreatitis. The idea was to see if giving probiotics reduced the incidence of developing (or improved the outcome of those with) infected necrotising pancreatitis. > The shocking results showed that 24 patients in the probiotic group died and only 9 in the non treated group. There have been " successes " reported in foreign literature but the numbers were smaller and the patients apparently less sick at beginning of therapy. > The researchers conclusions are that probiotics should NOT be given to " those that are very sick at admission " . > The reason it has taken them so long to know this is because only today the " key " as to which patients had received the probiotics and which hadn't was " broken " . > > To be taken into account I think is that the mortality from this complication is high in any case, although there clearly were huge differences. > > As a survivor of infected necrotising pancreatitis myself I think I have to be glad I was treated before this study commenced.... otherwise I might well have been in the " bad " group! > > DutchPat > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2008 Report Share Posted January 24, 2008 Hi Chaim, the only group is from the http://www.leverpatientenvereniging.nl/. But is not only for PSC patients. I am Spanish , living in Holland for 10 years now , and unfortunately they have been diagnosed me with PSC last November . My GI told me that I was her first case and I have asked for a second opinion from an Hepatologist in the VUMC in Amsterdam. I have an appointment the 4th of February . Regards Silvia > > > > > > The Dutch news have just reported that a research project from the > Academic Hospital in Utrecht has had stunning and unexpected > disastrous results. > > It concerned a double blind trial giving probiotic therapy to 300 > patienten in the last 3 years, suffering from pancreatitis. The idea > was to see if giving probiotics reduced the incidence of developing > (or improved the outcome of those with) infected necrotising > pancreatitis. > > The shocking results showed that 24 patients in the probiotic group > died and only 9 in the non treated group. There have been " successes " > reported in foreign literature but the numbers were smaller and the > patients apparently less sick at beginning of therapy. > > The researchers conclusions are that probiotics should NOT be given > to " those that are very sick at admission " . > > The reason it has taken them so long to know this is because only > today the " key " as to which patients had received the probiotics and > which hadn't was " broken " . > > > > To be taken into account I think is that the mortality from this > complication is high in any case, although there clearly were huge > differences. > > > > As a survivor of infected necrotising pancreatitis myself I think I > have to be glad I was treated before this study commenced.... > otherwise I might well have been in the " bad " group! > > > > DutchPat > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 24, 2008 Report Share Posted January 24, 2008 Hi Chaim, Pat and Silvia > That is interesting. I didn't know there were any dutchies on the PSC forum. I am originally from Holland but now live in Israel. Is there any dutch liver group (stichting) that deals specifically with PSC? I haven't found anything. > > Regards, > > Chaim Boermeester You can add one more tulip stomper to your tally but I'm in Canada though. Quote Link to comment Share on other sites More sharing options...
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