Re: Caffeine Plus Acetaminophen Toxic To Some Great!!

[Guest guest]

Thankyou for the info. This is certain what will happen to me. I already

fear the liver damage, from the long term vicodin I have had to use over the

yrs. The yrs. before that using high doses of tylenol for pain, and now all I do

is drink diet coke, water, and my med's except for my night meal. I have tried

to get myself to do 3 meals, I make my oatmeal and banana/flaxseed for

cholestorol, but usually can only get 1/2 down. I have been this way for yrs.

I always have had a worry of gaining weight, I guess it stems from being heavier

as a child. Now, I know I have been shown, it's been proven, if I will eat 3x I

will lose the few extra lbs I may put on now and then. I also know all the

med's combined continuously dumped in my gutt without food does not help, as my

digestive system is shot. I don't know but to give up the diet coke would I

can't do, and have tried trading it for the caffiene free, but just can't handle

the taste. This was a big problem when I

was on the natural pain relivers, vitaman diet given, I would vomit the vit's

up because I had not eaten, and would try and eat, before hand, but I just would

fall back to the no food all day routine as I don't get hungry. I think my

liver is doomed not matter what. How do I trade off saving it for the

unbearable pain, all the time, woke this a.m 3: with severe hip pain, new one

going down the leg with chill feeling??????!!!!!!!! Another winner day for me.

Hope your at a better day today.

Take Care Hope for lighter days ahead.

Sharon

wrote:

Caffeine Plus Acetaminophen Toxic To Some

Published: 09/26/07

WEDNESDAY, Sept. 26 (HealthDay News) -- Very high doses of caffeine and

acetaminophen (such as Tylenol), taken together, could lead to liver damage,

researchers warn.

This combo produces a byproduct enzyme that's toxic to the organ, researchers

from the University of Washington report.

This toxic twosome can occur not only by drinking caffeine while taking

acetaminophen, the experts added, but also from large doses of painkillers that

combine caffeine and acetaminophen. These painkillers are often used to treat

migraines, menstrual discomfort and other conditions.

" Caffeine can interact with an enzyme that can form a toxic metabolite of

acetaminophen in such a way that it increases the formation of that toxic

metabolite, " said lead researcher Sid , a professor of medicinal

chemistry. " This can result in liver damage, " he said.

In the study, 's team tested the effects of acetaminophen and caffeine on

E. coli bacteria. These bacteria had been genetically engineered to mimic a

human enzyme in the liver that detoxifies many prescription and nonprescription

drugs, explained the authors in a report in the Oct. 15 issue of the journal

Chemical Research in Toxicology.

noted that it takes large qualities of caffeine to produce this reaction.

" Normally people wouldn't be ingesting that amount of caffeine, " he said. " It

would take 10 times the amount of caffeine found in a couple of cups of coffee, "

said.

His team found that caffeine triples the amount of a toxin called

N-acetyl-p-benzoquinone imine (NAPQI) produced by the enzyme as it breaks down

acetaminophen.

This same toxin is also produced during an interaction between alcohol and

acetaminophen that's also well known to damage the liver.

In prior studies, 's team had found that high doses of caffeine boosted

liver damage in rats that had already suffered acetaminophen-linked liver

damage.

The bacteria used in the study were exposed to doses of acetaminophen and

caffeine far higher than most people would be exposed to, noted. It's not

clear at what point such a mixture becomes toxic, he said.

Some people may be more vulnerable to this toxic interaction than others,

said. They might include people who take certain antiepileptic medications, such

as carbamazepine and phenobarbital, and people who use the alternative remedy

St. 's Wort.

These drugs increase levels of the enzyme that produces NAPQI and may produce

even more when mixed with acetaminophen and caffeine together,

speculated.

In addition, because alcohol can boost NAPQI production, people who drink a lot

may be at increased risk for this toxic interaction, the researcher said. The

risk is also increased for people who take drugs that combine acetaminophen and

caffeine, used to treat migraines, arthritis and other conditions.

Still, for most people, there's no reason to panic, since the chances of

caffeine and acetaminophen becoming a toxic mixture remains small, said.

" Almost all people don't need to worry about taking caffeine with

acetaminophen, " said. Exceptions might be, " those [people] taking high

does of caffeine, high doses of acetaminophen, who are possibly alcoholic and/or

are epileptic and take certain anticonvulsive drugs, " he said.

More information

For more on acetaminophen, visit the U.S. National Library of Medicine.

Last reviewed: 09/26/2007 | Last updated: 09/26/2007

Quote of the Day

" Don't let other people tell you what you want. "

– Pat Riley

Quote of the Day

" Don't let other people tell you what you want. "

– Pat Riley

[Guest guest]

Thankyou for the info. This is certain what will happen to me. I already

fear the liver damage, from the long term vicodin I have had to use over the

yrs. The yrs. before that using high doses of tylenol for pain, and now all I do

is drink diet coke, water, and my med's except for my night meal. I have tried

to get myself to do 3 meals, I make my oatmeal and banana/flaxseed for

cholestorol, but usually can only get 1/2 down. I have been this way for yrs.

I always have had a worry of gaining weight, I guess it stems from being heavier

as a child. Now, I know I have been shown, it's been proven, if I will eat 3x I

will lose the few extra lbs I may put on now and then. I also know all the

med's combined continuously dumped in my gutt without food does not help, as my

digestive system is shot. I don't know but to give up the diet coke would I

can't do, and have tried trading it for the caffiene free, but just can't handle

the taste. This was a big problem when I

was on the natural pain relivers, vitaman diet given, I would vomit the vit's

up because I had not eaten, and would try and eat, before hand, but I just would

fall back to the no food all day routine as I don't get hungry. I think my

liver is doomed not matter what. How do I trade off saving it for the

unbearable pain, all the time, woke this a.m 3: with severe hip pain, new one

going down the leg with chill feeling??????!!!!!!!! Another winner day for me.

Hope your at a better day today.

Take Care Hope for lighter days ahead.

Sharon

wrote:

Caffeine Plus Acetaminophen Toxic To Some

Published: 09/26/07

WEDNESDAY, Sept. 26 (HealthDay News) -- Very high doses of caffeine and

acetaminophen (such as Tylenol), taken together, could lead to liver damage,

researchers warn.

This combo produces a byproduct enzyme that's toxic to the organ, researchers

from the University of Washington report.

This toxic twosome can occur not only by drinking caffeine while taking

acetaminophen, the experts added, but also from large doses of painkillers that

combine caffeine and acetaminophen. These painkillers are often used to treat

migraines, menstrual discomfort and other conditions.

" Caffeine can interact with an enzyme that can form a toxic metabolite of

acetaminophen in such a way that it increases the formation of that toxic

metabolite, " said lead researcher Sid , a professor of medicinal

chemistry. " This can result in liver damage, " he said.

In the study, 's team tested the effects of acetaminophen and caffeine on

E. coli bacteria. These bacteria had been genetically engineered to mimic a

human enzyme in the liver that detoxifies many prescription and nonprescription

drugs, explained the authors in a report in the Oct. 15 issue of the journal

Chemical Research in Toxicology.

noted that it takes large qualities of caffeine to produce this reaction.

" Normally people wouldn't be ingesting that amount of caffeine, " he said. " It

would take 10 times the amount of caffeine found in a couple of cups of coffee, "

said.

His team found that caffeine triples the amount of a toxin called

N-acetyl-p-benzoquinone imine (NAPQI) produced by the enzyme as it breaks down

acetaminophen.

This same toxin is also produced during an interaction between alcohol and

acetaminophen that's also well known to damage the liver.

In prior studies, 's team had found that high doses of caffeine boosted

liver damage in rats that had already suffered acetaminophen-linked liver

damage.

The bacteria used in the study were exposed to doses of acetaminophen and

caffeine far higher than most people would be exposed to, noted. It's not

clear at what point such a mixture becomes toxic, he said.

Some people may be more vulnerable to this toxic interaction than others,

said. They might include people who take certain antiepileptic medications, such

as carbamazepine and phenobarbital, and people who use the alternative remedy

St. 's Wort.

These drugs increase levels of the enzyme that produces NAPQI and may produce

even more when mixed with acetaminophen and caffeine together,

speculated.

In addition, because alcohol can boost NAPQI production, people who drink a lot

may be at increased risk for this toxic interaction, the researcher said. The

risk is also increased for people who take drugs that combine acetaminophen and

caffeine, used to treat migraines, arthritis and other conditions.

Still, for most people, there's no reason to panic, since the chances of

caffeine and acetaminophen becoming a toxic mixture remains small, said.

" Almost all people don't need to worry about taking caffeine with

acetaminophen, " said. Exceptions might be, " those [people] taking high

does of caffeine, high doses of acetaminophen, who are possibly alcoholic and/or

are epileptic and take certain anticonvulsive drugs, " he said.

More information

For more on acetaminophen, visit the U.S. National Library of Medicine.

Last reviewed: 09/26/2007 | Last updated: 09/26/2007

Quote of the Day

" Don't let other people tell you what you want. "

– Pat Riley

Quote of the Day

" Don't let other people tell you what you want. "

– Pat Riley