Dietary factors and inflammatory bowel disease

[Guest guest]

Dear All;

I thought that this article was of interest in relation to dietary

factors influencing early development of inflammatory bowel disease,

with emphasis on omega-3 fatty acids:

Innis SM, son K 2007 Dietary lipids in early development and

intestinal inflammatory disease. Nutr Rev. 65(12 Pt 2): S188-S193;

http://www.ncbi.nlm.nih.gov/pubmed/18240547

I thought I would also post this article from a brand new journal

called " Mucosal Immunology " on another dietary factor of major

importance, vitamin A:

Strober W 2008 Vitamin A rewrites the ABCs of oral tolerance. Mucosal

Immunology advance online publication 16 January.

http://npg.nature.com/mi/journal/vaop/ncurrent/abs/mi200722a.html

Vitamin A is the precursor of retinoic acid which has recently been

shown to play an important role in the development of regulatory T

cells (Tregs) which suppress inflammation, or which prevent the gut

mucosa from responding too drastically to all of the bacteria in the

gut. The dendritic cells in the gut associated lymphoid tissue (GALT)

are responsible for synthesis of retinoic acid from vitamin A, and this

retinoic acid favors Treg development [and at the same time suppresses

inflammatory Th17 cells], and " educates " the T cells as to where they

should go ... i.e. to the gut. In the absence of retinoic acid, the T

cells can get mis-directed to other organs, and this may be a cause of

PSC (and other extra-intestinal manifestations of IBD) according to

Drs. , and B. Eksteen! The retinoic acid also " educates " B

cells to start making IgA to keep gut bacteria in check.

Best regards,

Dave

(father of (22); PSC 07/03; UC 08/03)

[Guest guest]

Fascinating, and somewhat perplexing, in my case. I was raised on fairly

significant dietary portions of sardines, " fishballs " (you have to be Norske to

understand), lutefisk, freshwater fish, salmon, etc., so it's hard to see how I

may not have had enough omega-3s. However, I am of Scandinavian descent, so

there's a genetic predisposition. There must be some non-obvious difference, as

I'm the only one of my 4 siblings and known relatives with IBD or PSC.

Arne

---- wrote:

I thought that this article was of interest in relation to dietary

factors influencing early development of inflammatory bowel disease,

with emphasis on omega-3 fatty acids...