Immunopathogenesis of inflammatory bowel disease

[Guest guest]

http://www.wjgnet.com/1007-9327/abstract_en.asp?f=390 & v=14

Shih DQ, Targan SR.Immunopathogenesis of inflammatory bowel disease.World J Gastroenterol 2008 January;14(3):390-400Immunopathogenesis of inflammatory bowel diseaseShih DQ, Targan SR.Cedars-Sinai Inflammatory Bowel Disease Center, 8700 Beverly Blvd., Suite D4063, Los Angeles, CA 90048, United States. targans@...Crohn's disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn's disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis.