Dietary patterns and risk for Crohn's disease in children

[Guest guest]

http://www3.interscience.wiley.com/cgi-bin/abstract/117868132/ABSTRACT?CRETRY=1 & SRETRY=0

Original Article

Dietary patterns and risk for Crohn's disease in children

Savio D'Souza, MBBS 1, Emile Levy, PhD 1 2, Mack, MD 3, Israel, MD 4, Philippe Lambrette, MSc 2, Parviz Ghadirian, PhD 5, Colette Deslandres, MD 2 6, , PhD 7, Ernest G. Seidman, MD 2 8, Devendra K. Amre, PhD 2 6 *

1Department of Nutrition, University of Montreal, Montreal, Canada2Research Centre, Sainte-e Hospital, Montreal, Canada3Division of Gastroenterology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada4Division of Gastroenterology and Nutrition, British Columbia's Children's Hospital, Vancouver, Canada5Epidemiology Research Unit, Montreal University Research Center, Hôtel-Dieu, Montreal, Canada6Department of Pediatrics, University of Montreal, Montreal, Canada7Department of Human Genetics, McGill University Health Center, Montreal, Canada8Faculty of Medicine, Division of Gastroenterology, McGill University Health Center, Montreal, Canada

email: Devendra K. Amre (devendra.amre@...)

*Correspondence to Devendra K. Amre, Research Center, Bureau A-728, Ste-e Hospital, 3175 Cote-Sainte-, Montreal, Quebec H3T 1C5, Canada

Funded by: Canadian Institutes of Health Research (CIHR) Fonds de la Recherché en Santé du Québec (FRSQ) Research Chair Award from the Crohn's and Colitis Foundation of Canada (CCFC) and the CIHR

Keywords

Crohn's disease • dietary patterns • diet • pediatric • risk factors • nutrition

Abstract

Background: Some dietary foods are considered protective (vegetables and fruits), whereas others (fatty foods) are thought to enhance the risk for Crohn's disease (CD). The evidence, however, is inconsistent.

Methods: We postulated that specific dietary patterns may influence the risk for CD. A case-control study was carried out. Newly diagnosed CD cases with population and/or hospital-based controls 20 years were selected from 3 tertiary hospitals across Canada. Predisease diet was assessed using a validated food frequency questionnaire (FFQ) administered within 1 month of diagnosis. Factor analyses and unconditional logistic regression (adjusted) was used to determine gender-specific dietary patterns and assess associated risks for CD. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were estimated.

Results: A total of 149 cases and 251 controls were included. The mean age (range) of the cases was 13.3 (2.6-20 years). There were more boys (61.1%). Four dietary patterns each were observed among both boys and girls. Pattern 1 in girls, characterized by meats, fatty foods, and desserts, was positively associated with CD (OR 4.7, 95% CI 1.6-14.2). Pattern 2, common to both boys and girls, was characterized by vegetables, fruits, olive oil, fish, grains, and nuts and was inversely associated with CD in both genders (girls: OR 0.3, 95% CI 0.1-0.9; boys: OR 0.2, 95% CI 0.1-0.5).

Conclusions: Our results suggest that specific dietary patterns could be associated with higher or lower risks for CD in children. Larger prospective studies are required to confirm these findings.

(Inflamm Bowel Dis 2007)

Received: 25 May 2007; Accepted: 4 October 2007

Digital Object Identifier (DOI)10.1002/ibd.20333