Sedation with propofol for interventional endoscopic procedures: A risk factor analysis

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Sedation with propofol for interventional endoscopic procedures: A risk factor analysis

Authors: Till Wehrmann a; Riphaus a

Affiliation:

a Department of Internal Medicine I, Academic Hospital Siloah, Hannover, Germany

DOI: 10.1080/00365520701679181

Publication Frequency: 12 issues per year

Published in: Scandinavian Journal of Gastroenterology, Volume 43, Issue 3 2008 , pages 368 - 374 First Published on: 10 October 2007 Subjects: Gastroenterology; Gastrointestinal & Abdominal Surgery;

Formats available: HTML (English) : PDF (English)

Abstract

Objective. Propofol sedation for mainly diagnostic endoscopic procedures has proved safe in recent trials, with no need for endotracheal intubation. However, there is evidence that cardiorespiratory side effects occur more frequently and that assisted ventilation may be necessary if propofol sedation is performed for interventional endoscopic procedures.

Material and methods. Over a 6-year period, all adverse events (defined as premature termination of the procedure due to sedation-related events or either the need for assisted ventilation or admission to ICU) occurring during 9547 endoscopic interventions (UGI, n=5.374, ERCP, n=3.937, EUS, n=236) under propofol sedation were assessed.

Results. A total of 135 adverse events (1.4%) were documented. Assisted ventilation was necessary in 40 patients (0.4%); 9 patients required endotracheal intubation (0.09%); 28 needed further monitoring on the ICU (0.3%); and 4 patients died, 3 potentially due to sedation-related side effects (mortality, 0.03%). Independent risk factors for sedation-related side effects were emergency endoscopic examinations and a total propofol dose >100 mg.

Conclusions. Interventional endoscopy under propofol sedation is not risk-free. Increased attention must be focused on close monitoring of vital parameters, particularly when undertaking long-lasting interventions and emergency procedures.

Keywords: Endoscopy; propofol; risk factors; sedation; side effects