CXCL16 is a surrogate marker of inflammatory bowel disease

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CXCL16 is a surrogate marker of inflammatory bowel disease

Authors: Lehrke a; Astrid Konrad - Lehrke and Astrid Konrad contributed equally to this worka; Veronika Schachinger a; Cornelia Tillack a; Seibold b; Stark c; Klaus G. Parhofer a; Uli C. Broedl a

Affiliations:

a Department of Internal Medicine II, University of Munich, Germany

b Division of Gastroenterology, Inselspital, University of Bern, Switzerland

c GSF-Institut für Gesundheitsökonomie und Management im Gesundheitswesen, Neuherberg, Germany

DOI: 10.1080/00365520701679249

Publication Frequency: 12 issues per year

Published in: Scandinavian Journal of Gastroenterology, Volume 43, Issue 3 2008 , pages 283 - 288 First Published on: 12 October 2007 Subjects: Gastroenterology; Gastrointestinal & Abdominal Surgery;

Formats available: HTML (English) : PDF (English)

Abstract

Objective. Impaired barrier function of the gut and inadequate immunological response to intestinal pathogens are the cornerstones in the pathogenesis of inflammatory bowel disease (IBD). CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine. The relevance of CXCL16 in IBD has so far been elusive. This objective of this study was to determine the association between CXCL16 and IBD.

Material and methods. Soluble CXCL16 (sol-CXCL16) serum levels in a cohort of 239 patients with Crohn's disease were measured, 114 patients with ulcerative colitis and 144 controls.

Results. In a univariate analysis, sol-CXCL16 was found to be markedly increased in patients with Crohn's disease or ulcerative colitis compared with that in controls (p < 0.001). This was significantly associated with an increase of the inflammatory marker C-reactive protein (CRP) (p < 0.01). In the multivariate analysis (adjusted for age, gender, body mass index (BMI), white blood cell (WBC) count, resistin and CRP) sol-CXCL16 was associated with Crohn's disease above versus below the median (OR 10.53 (3.97-27.78) p < 0.001) and ulcerative colitis (OR 3.46 (1.40-8.55) p < 0.01).

Conclusion. Our findings suggest that CXCL16 may play a pro-inflammatory role in IBD, particularly Crohn's disease.

Keywords: Crohn's disease; CXCL16; disease activity; inflammatory bowel disease; ulcerative colitis