Autoantibodies to glutathione S-transferase theta 1 in patients with PSC & other autoimmune diseases.

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Autoantibodies to glutathione S-transferase theta 1 in patients with primary sclerosing cholangitis and other

autoimmune diseases.

To address this issue, we constructed a cDNA library from normal human choledochus

and screened expressing clones with serum from a patient with PSC and

inflammatory bowel disease (IBD). Based on this

screening, glutathione S-transferase theta 1 (GSTT1)

was identified as a potential autoantigenic target. To study the specificity of GSTT1, we determined immunoreactivity using a panel of 58 patients with PSC,

with and without IBD…………..

http://www.ncbi.nlm.nih.gov/pubmed/18242955

Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (33) UC 91 - PSC 99 - Tx 6/21 & 6/30/07 @ Baylor in Dallas