Biomarkers for Mood May Alter Psychiatric Treatments

March 3, 2008

Published: 02/28/08

THURSDAY, Feb. 28 (HealthDay News) -- Biomarkers in the blood associated with

mood disorders have been identified by Indiana University School of Medicine

researchers, who said the finding may change the way bipolar illness is

diagnosed and treated.

The researchers analyzed blood samples from 96 patients and found varying

levels of the biomarkers in participants with high or low mood states. They also

found that concentrations of the biomarkers varied, depending on the severity of

depression or mania or a patient's individual experiences.

" This discovery is a major step towards bringing psychiatry on par with other

medical specialties that have diagnostic tools to measure disease states and the

effectiveness of treatments, " study author Dr. B. Niculescu, an

assistant professor of psychiatry, medical neurobiology and neuroscience at the

university's School of Medicine Institute of Psychiatric Research, said in a

prepared statement.

" Although psychiatrists have been aware that bipolar illness and other

psychiatric conditions produced molecular changes in the brain, there was no way

to measure those changes while the patient was still living. Blood can now be

used as a surrogate tissue to diagnose and assess the severity of the illness, "

Niculescu said.

He said this line of research could have a major impact on the treatment of a

wide range of mood disorders, including postpartum depression, post-traumatic

stress disorder and assessments for bereavement interventions.

The study was published in the Feb. 26 online issue of Molecular Psychiatry.

Niculescu and his colleagues are planning a larger study to examine the impact

of treatment on these mood disorder biomarkers. They also plan to look for

biomarkers associated with other kinds of psychiatric diseases.

More information

The U.S. National Institute of Mental Health has more about bipolar disorder.

Last reviewed: 02/28/2008 | Last updated: 02/28/2008

When you have nothing left but God,

you become aware that God is enough.

-Guideposts

Recommended Posts