SchaferAutismReport: Mitochondrial Dysfunction Linked to Autism

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RESEARCH

Mitochondrial Dysfunction Linked to Autism

By http://xrl.in/75g2

Dr.

A. Rossignol

Mitochondrial dysfunction (MD) is more

common in children with autism and autism spectrum disorder (ASD) than

the general population, a comprehensive systematic review and

meta-analysis of relevant research confirms.

Mitochondrial dysfunction "may play a

significant role in contributing to the symptoms of autism and is

generally underrecognized in these children," A. Rossignol, MD,

of the International Child Development Resource Center, Melbourne,

Florida, told Medscape Medical News.

"Testing for mitochondrial dysfunction

is available, and early treatment might lead to better long-term

developmental outcomes," said Dr. Rossignol, who coauthored the review

with E. Frye, MD, PhD, of the University of Texas in Houston.

The report was published online January

25 in Molecular Psychiatry.

Commenting on the study Cecilia Giulivi,

PhD, professor of biochemistry and metabolic regulation, at the

University of California, , who was not involved in the analysis,

said, "At this point, it looks like there is a higher incidence of

mitochondrial disease in autism, much higher than we suspected."

She noted, however, that testing for MD

"is not a trivial task [and] we need more research to come up with a

consensus of diagnostic tests to run. In addition, maybe other

metabolic syndromes should be looked into," Dr. Giulivi said.

The primary objectives of the analysis

were to identify features of MD in the general population of children

with ASD and compare characteristics of MD in children with ASD and

concomitant significant and severe MD with that of ASD children without

MD and non-ASD children with MD.

They included 68 relevant published

articles in a qualitative synthesis, including 18 studies with a

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RESEARCH

Mitochondrial Dysfunction Linked to Autism

Understanding the Autistic Mind: Evidence That Autistic Patients Have

Trouble Understanding Other People's Intentions

Bacteria in the Gut May Influence Brain Development

PUBLIC HEALTH

EPA to Regulate Toxic Chemicals In Drinking Water

NEWS

Nebraska Court Upholds Involuntary Commitments For People With

Disabilities

PEOPLE

Woman Sues NYC Over Alleged Sex Assault Of Autistic Son

Mother Of Boy Voted Out Of Class Receives Hefty Settlement

Parents Held Not Liable for Murders by Autistic Son

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Announcing Project Touch: Free Apple iTouch to Needy Virginia Children

with Autism

EVENTS

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COMMENTARY

EPA Claim: We Regulate Drinking Water to Protect Kids from Autism

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